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Clinical Applications of Cardiac Imaging: 2nd Edition
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Clinical Applications of Cardiac Imaging: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 902

Special Issue Editor

Dr. Maria Concetta Pastore

E-Mail Website
Guest Editor
Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy
Interests: heart failure; acute heart failure; valvular heart disease; echocardiography; advanced echocardiography; clinical cardiology; cardiovascular medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the success of our first Special Issue, entitled “Clinical Application of Cardiac Imaging” (https://www.mdpi.com/si/jcm/15FPYNVTSB), we are launching a new Special Issue, entitled “Clinical Applications of Cardiac Imaging: 2nd Edition”, which continues to report on clinical research.

Cardiac imaging is a pivotal tool in the diagnosis, management, and treatment of cardiovascular diseases. Its non-invasive or minimally invasive nature makes it a safe and effective option for patients, possessing considerable accuracy compared to invasive techniques. Clinicians should consider cardiac imaging in their diagnostic and treatment pathways for patients with suspected or confirmed cardiovascular disease.

This Special Issue, entitled “Clinical Applications of Cardiac Imaging: 2nd Edition", explores various imaging techniques and their applications in the diagnostic and prognostic assessment of cardiovascular diseases. It further discusses the role of multimodality imaging in guiding therapeutic management and interventions, such as cardiac catheterization, electrophysiology studies, and heart surgery, addressing topics such as echocardiography, cardiac magnetic resonance imaging, computed tomography, and nuclear imaging.

Overall, this Special Issue aims to provide a platform for researchers to share their latest findings related to the current state of cardiac imaging and its clinical applications. It will demonstrate the significance of various imaging modalities in the diagnosis and management of cardiac disease, discuss the recent advances in scientific knowledge and highlight the need for continued research and innovation in this field, and address the challenges and limitations of cardiac imaging.

Dr. Maria Concetta Pastore
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac imaging
  • echocardiography
  • magnetic resonance imaging
  • computed tomography
  • nuclear imaging
  • heart failure
  • valvular heart disease
  • congenital heart disease

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Related Special Issue

Published Papers (2 papers)

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Research

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10 pages, 680 KB  
Article
Non-Ischemic Pattern of LGE After COVID-19 Correlates More with Severity of Acute Illness than with Long-Term Myocardial Dysfunction
by Alessandro Pingitore, Filippo Figini, Laura Pederzoli, Patrizia Landi, Luca Bastiani, Claudio Marabotti and Filippo Leonardo
J. Clin. Med. 2025, 14(21), 7477; https://doi.org/10.3390/jcm14217477 - 22 Oct 2025
Viewed by 304
Abstract
Background/Objectives: Myocarditis can occur in patients with coronavirus disease 2019 (COVID-19) as part of the systemic involvement of this infectious syndrome. The persistence of this non-ischemic late gadolinium enhancement (LGE) pattern can be considered an indicator of ongoing myocardial involvement or a [...] Read more.
Background/Objectives: Myocarditis can occur in patients with coronavirus disease 2019 (COVID-19) as part of the systemic involvement of this infectious syndrome. The persistence of this non-ischemic late gadolinium enhancement (LGE) pattern can be considered an indicator of ongoing myocardial involvement or a sequela of myocarditis. We aimed to assess the effects of LGE on cardiac function and morphology in patients with COVID-19 admitted in intensive care unit for acute respiratory distress syndrome. Methods: Fifty patients (age 59 ± 11, female n = 15) were enrolled. Results: The prevalence of LGE was 33.3%. LGE was present in the lateral wall in all patients except for one, with LGE positivity at the interventricular septum. In general, patients with and without LGE had similar CMR variables values. In one case, LGE was associated with regional wall motion abnormality. The factor associated with LGE was the duration of hospitalization (7.97 ± 3.8 and 12.5 ± 6.7 days in patients without and with LGE, p = 0.007). Conclusions: LGE non-ischemic pattern was not associated with left ventricular dilatation or dysfunction or remodeling in patients with severe clinical manifestation of COVID-19. LGE is mainly present in patients with more prolonged duration of hospitalization. LGE may represent a residual scar with limited prognostic impact that larger multicenter studies could confirm. Full article
(This article belongs to the Special Issue Clinical Applications of Cardiac Imaging: 2nd Edition)
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Review

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28 pages, 3784 KB  
Review
Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Symptomatic Individuals with Primary Mitral Regurgitation? A Narrative Review of Traditional and Innovative Prognostic Indicators
by Andrea Sonaglioni, Gian Luigi Nicolosi, Michele Lombardo and Massimo Baravelli
J. Clin. Med. 2025, 14(23), 8297; https://doi.org/10.3390/jcm14238297 - 22 Nov 2025
Viewed by 310
Abstract
Primary mitral regurgitation (PMR) is the most common mitral valve disorder in clinical practice. Although several prognostic indicators derived from resting transthoracic echocardiography (TTE) and exercise stress echocardiography (ESE) are available, patient outcomes remain highly variable, with substantial differences in complication rates and [...] Read more.
Primary mitral regurgitation (PMR) is the most common mitral valve disorder in clinical practice. Although several prognostic indicators derived from resting transthoracic echocardiography (TTE) and exercise stress echocardiography (ESE) are available, patient outcomes remain highly variable, with substantial differences in complication rates and mortality. Identifying individuals at lower cardiovascular risk is therefore clinically relevant, as they represent a large proportion of cases. Current guidelines recommend an integrative approach—combining qualitative, semi-quantitative, and quantitative indices—to determine the timing of intervention, but they do not specifically address risk stratification in low-risk PMR populations. Recent studies have highlighted the potential prognostic value of chest wall configuration, assessed noninvasively using the Modified Haller Index (MHI). Defined as the ratio of latero-lateral thoracic diameter to the antero-posterior (A-P) sternum–spine distance, MHI appears to influence myocardial deformation indices obtained by speckle-tracking echocardiography (STE). Patients with PMR due to mitral valve prolapse (MVP) often show a reduced A-P thoracic diameter caused by sternal depression. Among these, those with an MHI > 2.5 or A-P diameter ≤ 13.5 cm display greater impairment in global and basal strain, particularly in longitudinal and circumferential directions. These abnormalities likely reflect extrinsic geometric constraints and cardiac displacement leading to apparent dyssynchrony rather than intrinsic myocardial dysfunction. A reduced A-P diameter was also independently associated with mitral annular disjunction (MAD) in MVP and emerged as a determinant of impaired strain in this subgroup. In a retrospective cohort of 424 symptomatic MVP patients with moderate MR undergoing ESE, positive tests and exercise-induced severe MR were uncommon. Importantly, an MHI > 2.5 or an A-P diameter ≤ 13.5 cm was associated with a favorable medium-term prognosis, with few adverse cardiovascular events. This narrative, non-systematic review, based on a structured but non-PRISMA literature search, summarizes current evidence on conventional and novel echocardiographic prognostic markers and their implications for risk stratification in PMR. As such, it carries inherent limitations, including potential selection bias, incomplete retrieval of unpublished or negative studies, and reliance on single-center observational data. The findings should therefore be interpreted cautiously and validated through larger, independent, multicenter investigations. Full article
(This article belongs to the Special Issue Clinical Applications of Cardiac Imaging: 2nd Edition)
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