Recent Developments in the Genetics of Attention-Deficit Hyperactivity Disorder
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 4594
Special Issue Editor
Special Issue Information
Dear Colleagues,
Attention-deficit hyperactivity disorder is the most common neurodevelopmental disorder worldwide and persists into adulthood in about 60% of cases. Despite high heritability, with estimates of up to 80% based on twin and family studies, the genetic architecture of ADHD remains widely unknown. In addition, common and rare variants seem to be involved in ADHD genetic liability, though environmental and developmental factors also play a role. Disentangling the contribution of environment and genes is rather complex, however, recent studies with adequate designs that do just so are emerging. Furthermore, the increasing numbers of participants in the latest genome-wide association studies (GWAS) have revealed the first genome-wide loci associated with significant risk of ADHD development. Still, the molecular contribution of those risk gene variants to ADHD pathology have yet to be characterized, and new technologies like patient-derived neuronal cell models and brain organoids via human-induced pluripotent stem cells (hiPSC) might contribute to further elucidating the role of risk gene variants. Furthermore, emerging evidence points not only to a shared genetic risk between ADHD and other mental disorders but also somatic diseases, which seem to occur more frequently in ADHD. Therefore, given the increasing number of samples, new technologies, and sophisticated study designs, we will advance the goal of unravelling the mystery of the missing heritability of ADHD.
Prof. Dr. Sarah Kittel-Schneider
Guest Editor
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Keywords
- attention deficit hyperactivity disorder
- ADHD
- ADD
- genetics
- risk gene variants
- single-nucleotide polymorphisms
- SNPs
- copy number variants (CNV)
- human-induced pluripotent stem cells (hiPSC)
- brain organoids
- somatic comorbidity
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