Journal of Clinical Medicine

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Dear Colleagues,

Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure used to treat aortic valve stenosis. The development of newer and more advanced prosthetic valves will likely enhance the durability, functionality, and long-term outcomes of TAVR procedures. These valves may be designed to be more compatible with patients’ anatomy, reducing the risk of complications. Currently, TAVR is primarily indicated for high-risk or inoperable patients. However, ongoing research and clinical trials aim to expand the indications for TAVR to include lower-risk patients, younger patients, and those with bicuspid aortic valves, making TAVR accessible to a broader population. In addition, hybrid approaches combining TAVR with other interventions, such as coronary artery bypass grafting (CABG) or mitral valve repair, may become more common. These combined procedures can address multiple cardiac conditions simultaneously, providing comprehensive treatment options.

This Special Issue aims to update readers with the latest clinical research in surgical and transcatheter aortic valve replacement. We invite authors to share their valuable opinions and the results of their research as original or review papers. We would be very grateful for your outstanding contribution to the further development of TAVR.

Dr. Chayakrit Krittanawong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

TAVR
interventional cardiology
aortic stenosis
bicuspid valve
minimally invasive surgery

Published Papers (2 papers)

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Editorial

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7 pages, 4074 KiB

Open AccessEditorial

Clinical Outcome of TAVI vs. SAVR in Patients with Severe Aortic Stenosis

by Chayakrit Krittanawong, Hafeez Ul Hassan Virk, Joshua Hahn, Zhen Wang, Fu’ad Al-Azzam, Mahboob Alam, Samin Sharma and Hani Jneid

J. Clin. Med. 2023, 12(16), 5236; https://doi.org/10.3390/jcm12165236 - 11 Aug 2023

Viewed by 1468

Abstract

The utilization of transcatheter aortic valve implantation (TAVI) has become the treatment of choice in patients with severe aortic stenosis (AS) with intermediate-to-high surgical risk for surgical aortic valve replacement (SAVR) [...] Full article

(This article belongs to the Special Issue Interventional Cardiology: Transcatheter Aortic Valve Replacement (TAVR) in 2023 and Beyond)

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Research

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18 pages, 2938 KiB

Open AccessArticle

Coronary Revascularization after Transcatheter and Surgical Aortic Valve Replacement

by Davide Gabbieri, Federico Giorgi, Greta Mascheroni, Matteo Chiarabelli, Giuseppe D’Anniballe, Marco Meli, Clorinda Labia and Italo Ghidoni

J. Clin. Med. 2023, 12(23), 7257; https://doi.org/10.3390/jcm12237257 - 23 Nov 2023

Viewed by 711

Abstract

Introduction: Due to the selective criteria and short-term follow-up of previous transcatheter aortic valve implantation (TAVI) trials, the coronary revascularization incidence after TAVI has been difficult to determine. This study investigated the epidemiology of coronary revascularization after surgical aortic valve replacement (SAVR) and TAVI in patients with severe aortic valve stenosis (AS), with and without coronary artery disease (CAD), in a mid-term follow-up, single-center, real-world setting. Methods: Between 2010 to 2020, 1486 patients with AS underwent SAVR or TAVI with balloon-expandable Edwards^® transcatheter heart valves (THVs). Using hospital discharge records, we could estimate for each patient resident in Emilia Romagna the rate of ischemic events treated with percutaneous coronary intervention (PCI). A subgroup without CAD was also analyzed. Results: The 5-year overall survival was 78.2%. Freedom from PCI after AVR and TAVI at 5 years was 96.9% and 96.9%, respectively, with previous PCI as a predictor (HR 4.86, 95% CI 2.57–9.21 p < 0.001). The freedom from PCI curves were not significantly different. Conclusions: Notwithstanding the aged population, the revascularization incidence was only 2.4%, requiring further evaluation even in younger patients with longer follow-up. Despite the profile frame raise due to the evolution of Edwards^® balloon-expandable THVs, PCI or coronarography feasibility were not compromised in our population. Full article

(This article belongs to the Special Issue Interventional Cardiology: Transcatheter Aortic Valve Replacement (TAVR) in 2023 and Beyond)

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