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New Insights into Augmentative Therapy for Parkinson’s Disease
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New Insights into Augmentative Therapy for Parkinson’s Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 2589

Special Issue Editor

Dr. Adam Thrasher

E-Mail Website
Guest Editor
Center for Neuromotor and Biomechanics Research, Department of Health and Human Performance, University of Houston, Houston, TX, USA
Interests: movement disorders; rehabilitation engineering; neuromodulation

Special Issue Information

Dear Colleagues,

Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disorder in the world. It is projected that 12 to 17 million people worldwide will be affected by PD by the year 2040. In the early stages of the disease, motor symptoms can usually be treated with dopaminergic medications. However, as the disease progresses, management of drug dosage and scheduling becomes complex and often associated with motor fluctuations and dyskinesia. The symptoms of postural instability and gait disturbances (PIGDs) are particularly challenging to treat. There is a growing need for innovative therapies that can enhance the conventional treatment approaches to PD.

This Special Issue is dedicated to exploring augmentative therapies for PD. Our goal is to bring to light new developments in non-pharmacological interventions targeting motor symptoms, such as physical activity-based therapies, neuromodulation, gene therapy, etc.

In this Special Issue, we invite original articles and reviews from experts in the field. We eagerly await your contributions.

Dr. Adam Thrasher
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s Disease
  • postural instability
  • locomotion
  • physical therapy
  • neuromodulation
  • augmentative therapies

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Published Papers (2 papers)

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Research

10 pages, 779 KiB  
Article
Study on Pharmacological Treatment of Impulse Control Disorders in Parkinson’s Disease
by Emilia Furdu-Lunguț, Claudia Antal, Suzana Turcu, Dan-Gabriel Costea, Mihai Mitran, Loredana Mitran, Andrei-Sebastian Diaconescu, Marius-Bogdan Novac and Gabriel-Petre Gorecki
J. Clin. Med. 2024, 13(22), 6708; https://doi.org/10.3390/jcm13226708 - 8 Nov 2024
Viewed by 1164
Abstract
Parkinson’s disease is neurodegenerative, and additionally, a percentage higher than 60% is represented by the patients with associated psychiatric symptoms, such as anxiety disorders and depression. Due to illness itself and to therapy secondary effects, there is a high risk for these patients [...] Read more.
Parkinson’s disease is neurodegenerative, and additionally, a percentage higher than 60% is represented by the patients with associated psychiatric symptoms, such as anxiety disorders and depression. Due to illness itself and to therapy secondary effects, there is a high risk for these patients to develop impulse control disorders like ICDs: compulsive shopping, pathological gambling binge eating disorder, and hypersexuality. There is high interest in therapy so as to diminish, as much as possible, the associated ICD symptoms. This article presents a study on pharmacological treatment of impulse control disorders in Parkinson disease carried on a sample of patients in hospitals where the authors have their clinical work. This study was carried on for a period of 6 years and is focused on research of different treatment plans. The patients were evaluated by the Hamilton Rating Scale. Statistical analysis of the obtained data (given by the HAM-A scores) is used for data processing. All patients showed a reduction in their impulse behavior. The directions of further research development are mentioned. Full article
(This article belongs to the Special Issue New Insights into Augmentative Therapy for Parkinson’s Disease)
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14 pages, 2181 KiB  
Article
The Influence of Dopaminergic Medication on Regularity and Determinism of Gait and Balance in Parkinson’s Disease: A Pilot Analysis
by Craig D. Workman and T. Adam Thrasher
J. Clin. Med. 2024, 13(21), 6485; https://doi.org/10.3390/jcm13216485 - 29 Oct 2024
Viewed by 935
Abstract
Background/Objectives: Understanding how dual-tasking and Parkinson’s disease medication affect gait and balance regularity can provide valuable insights to patients, caregivers, and clinicians regarding frailty and fall risk. However, dual-task gait and balance studies in PD most often only employ linear measures to [...] Read more.
Background/Objectives: Understanding how dual-tasking and Parkinson’s disease medication affect gait and balance regularity can provide valuable insights to patients, caregivers, and clinicians regarding frailty and fall risk. However, dual-task gait and balance studies in PD most often only employ linear measures to describe movement regularity. Some have used nonlinear techniques to analyze PD performances, but only in the on-medication state. Thus, it is unclear how the nonlinear aspects of gait or standing balance are affected by PD medication. This study aimed to assess how dopaminergic medication influenced the regularity and determinism of joint angle and anterior–posterior (AP) and medial–lateral (ML) center of pressure (COP) path time-series data while single- and dual-tasking in PD. Methods: Sixteen subjects with PD completed single- and dual-task gait and standing balance trials for 3 min off and on dopaminergic medication. Sample entropy and percent determinism were calculated for bilateral hip, knee, and shoulder joints, and the AP and ML COP path. Results: There were no relevant medication X task interactions for either the joint angles series or the balance series. Instead, the results supported independent effects of medication, dual-tasking, or standing with eyes closed. Balance task difficulty (i.e., eyes open vs. eyes closed) was detected by the nonlinear analyses, but the nonlinear measures yielded opposing results such that standing with eyes closed simultaneously yielded less regular and more deterministic signals. Conclusions: When juxtaposed with previous findings, these results suggest that medication-induced functional improvements in people with PD might be accompanied by a shift from lesser to greater signal consistency, and the effects of dual-tasking and standing with eyes closed were mixed. Future studies would benefit from including both linear and nonlinear measures to better describe gait and balance performance and signal complexity in people with PD. Full article
(This article belongs to the Special Issue New Insights into Augmentative Therapy for Parkinson’s Disease)
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