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Degenerative Spinal Disease: Clinical Advances and Perspectives
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Degenerative Spinal Disease: Clinical Advances and Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (24 April 2025) | Viewed by 244

Special Issue Editor

Prof. Dr. Tae-Hwan Kim

E-Mail Website
Guest Editor
Spine Center, Department of Orthopedics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro, 170beon-gil, Dongan-gu, Anyang 14068, Republic of Korea
Interests: spinal infection; vertebral osteomyelitis; degenerative disease; spinal oncology; spine surgery; spinal instrumentation; surgical outcome

Special Issue Information

Dear Colleagues,

Degenerative spinal disease is one of the most prevalent conditions encountered throughout life, with its incidence sharply rising with age. This condition significantly impacts the quality of life in elderly patients, prompting the development and implementation of numerous diagnostic and therapeutic approaches by healthcare professionals. The importance of clinical research in this area cannot be overstated.

In this Special Issue, "Degenerative Spinal Disease: Clinical Advances and Perspectives", of the Journal of Clinical Medicine, we are seeking research from various clinical fields that focus on degenerative spinal disease. We are particularly interested in the following:

  1. Epidemiologic studies that reveal recent trends in the prevalence and impact of the disease.
  2. Clinical assessment tools that objectively evaluate the symptoms and suffering of patients.
  3. Imaging and non-imaging studies for clinical evaluation and differential diagnosis.
  4. Therapeutic outcomes, including assessments of treatment efficacy and associated complications.
  5. Rehabilitation strategies aimed at enhancing patient recovery and quality of life.

We invite authors to submit their work to this Special Issue, with an emphasis on the recent clinical advances and perspectives in managing degenerative spinal disease. We hope this collection of research will contribute to improving the quality of life for those affected by this condition.

Prof. Dr. Tae-Hwan Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • degenerative spinal disease
  • epidemiology
  • clinical assessment
  • imaging study
  • therapeutic outcome
  • complication
  • rehabilitation

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

11 pages, 1651 KiB  
Article
Time Course of Functional Recovery Following Single-Level Anterior Lumbar Interbody Fusion with and Without Posterior Instrumentation: A Retrospective Single-Institution Study
by Tejas Subramanian, Stephane Owusu-Sarpong, Sophie Kush, Adin M. Ehrlich, Tomoyuki Asada, Eric R. Zhao, Kasra Araghi, Takashi Hirase, Austin C. Kaidi, Gregory S. Kazarian, Farah Musharbash, Luis Felipe Colón, Adrian T. H. Lui, Atahan Durbas, Olivia C. Tuma, Pratyush Shahi, Kyle W. Morse, Francis C. Lovecchio, Evan D. Sheha, James E. Dowdell, Han Jo Kim, Sheeraz A. Qureshi and Sravisht Iyeradd Show full author list remove Hide full author list
J. Clin. Med. 2025, 14(13), 4397; https://doi.org/10.3390/jcm14134397 - 20 Jun 2025
Abstract
Background/Objectives: While anterior lumbar interbody fusion (ALIF) is a well-established treatment for degenerative lumbar spine pathology, the timing and pace of postoperative recovery remain poorly defined. Understanding these temporal trends is clinically important for setting patient expectations and optimizing postoperative care. Methods [...] Read more.
Background/Objectives: While anterior lumbar interbody fusion (ALIF) is a well-established treatment for degenerative lumbar spine pathology, the timing and pace of postoperative recovery remain poorly defined. Understanding these temporal trends is clinically important for setting patient expectations and optimizing postoperative care. Methods: This retrospective single-institution study evaluated functional recovery in patients undergoing primary, single-level stand-alone (SA) ALIF, or with percutaneous posterior instrumentation (PI). Patient-reported outcome measures (PROMs), including the Oswestry Disability Index (ODI), the Visual Analog Scale (VAS) for back and leg pain, and the SF-12 Physical Component Score (PCS), were assessed preoperatively and at 2 weeks, 6 weeks, 3 months, 6 months, 1 year, and 2 years postoperatively. Achievement of minimum clinically important difference (MCID), global rating change (GRC), and return-to-activity milestones were also analyzed. Results: A total of 143 patients were included (90 SA; 53 PI). PROMs showed significant improvement through 1 year. VAS-back improved by 2 weeks, while ODI and SF12 PCS initially worsened but improved after 6 weeks. By 6 months, over half of the cohort achieved MCID, with continued gains through 1 year. Most patients returned to driving and work, and over 90% discontinued narcotics. Recovery trajectories were comparable between groups, despite early delays in the instrumented cohort. Conclusions: These findings provide time-specific recovery benchmarks that can guide surgical decision-making, patient education, and expectations around functional milestones. Full article
(This article belongs to the Special Issue Degenerative Spinal Disease: Clinical Advances and Perspectives)
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