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New Advances in Age-Related Macular Degeneration

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 705

Special Issue Editor


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Guest Editor
Tel Aviv Medical Center, Department of Ophthalmology, Tel Aviv University, Tel Aviv 6423906, Israel
Interests: age-related macular degeneration; AMD; glaucoma; OCT

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight the latest advancements in our understanding and the management of age-related macular degeneration (AMD), a leading cause of vision loss among older adults. With the increasing prevalence of AMD, it is essential to explore innovative approaches to diagnosis, treatment, and patient care.

We invite submissions that focus on recent research findings, including novel therapeutic interventions, advancements in imaging technologies, and insights into the disease's pathophysiology. Manuscripts may encompass clinical trials, epidemiological studies, and review articles that shed light on emerging treatments.

Our goal is to create a platform for sharing valuable knowledge that can inform clinical practice and improve patient outcomes in AMD. By gathering diverse perspectives and cutting-edge research, this Special Issue seeks to provide a comprehensive understanding of the current landscape of AMD management, ultimately fostering advancements in patient care and preserving vision for those affected by this condition.

Dr. Omer Trivizki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wet age-related macular degeneration
  • dry age-related macular degeneration
  • retinal imaging
  • drusen
  • intravitreal injections
  • ocular angiogenesis
  • visual rehabilitation

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Published Papers (1 paper)

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Research

14 pages, 7335 KB  
Article
Retinal Vessel Coronal Displacement in Intermediate Age-Related Macular Degeneration
by Mariacristina Parravano, Serena Fragiotta, Maria Sole Polito, Monica Varano, Giorgio Querzoli and Tommaso Rossi
J. Clin. Med. 2025, 14(17), 6030; https://doi.org/10.3390/jcm14176030 - 26 Aug 2025
Viewed by 452
Abstract
Introduction: This pilot study aimed to test the feasibility of a novel vectorial image analysis method to quantify coronal microvascular displacement in different retinal plexuses in intermediate age-related macular degeneration (iAMD) over 6 months. Material and methods: A retrospective series of [...] Read more.
Introduction: This pilot study aimed to test the feasibility of a novel vectorial image analysis method to quantify coronal microvascular displacement in different retinal plexuses in intermediate age-related macular degeneration (iAMD) over 6 months. Material and methods: A retrospective series of iAMD patients with at least 6-month follow-up was included if they had complete medical records, best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and OCT angiography (OCTA). En-face (coronal) vascular displacement between baseline and 6 months was assessed in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using the Farneback motion tracking algorithm applied to consecutive OCTA scans. Results: Eighteen eyes of 18 iAMD patients met the inclusion criteria. Average coronal vascular displacement (T0–T6) was 13.7 ± 7.72 µm for the SCP, 15.11 ± 10.06 µm for the DCP, and 19.02 ± 12.25 µm for the CC slab. Reticular pseudodrusen (RPD) was associated with greater displacement in the DCP (p = 0.047), but not in the SCP (p = 0.980) or CC (p = 0.473). Quantitative analysis confirmed the highest DCP displacement in RPD eyes (66.7%, p = 0.02), while drusenoid pigment epithelial detachment showed the greatest reorganization in the CC (100%, p = 0.02). Discussion: Retinal vessels undergo significant tangential displacement in iAMD, suggesting a structural reorganization of the microvasculature. Such remodeling may constitute a compensatory response to ultrastructural alterations resulting in ischemia. Full article
(This article belongs to the Special Issue New Advances in Age-Related Macular Degeneration)
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