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Advances in Echocardiography and Its Clinical Applications
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Advances in Echocardiography and Its Clinical Applications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2001

Special Issue Editor

Dr. Simona Sperlongano

E-Mail Website
Guest Editor
Division of Cardiology, Department of Traslational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy
Interests: echocardiography; stress echocardiography; transesophageal echocardiography; 3D echocardiography; heart valve diseases; structural heart disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Thanks to its wide availability, relatively low cost, non-invasive nature, rapidity of execution, and portability, echocardiography remains the pivotal imaging technique for the diagnosis and management of most cardiovascular diseases and is most commonly used as procedural guidance.

Over the last few decades, novel echocardiographic modalities, including contrast echocardiography, speckle tracking imaging, three-dimensional echocardiography, and intracardiac flow dynamics, have been developed with the aim of providing new insights into the pathophysiological mechanisms underlying cardiovascular diseases. This scenario of advances in echocardiography also includes automatic and semi-automatic artificial intelligence algorithms, which support the operator in optimizing image quality and taking measurements.

In this Special Issue of the Journal of Clinical Medicine, we welcome authors to submit papers on advances in echocardiography in terms of diagnosis, risk stratification, and the management of cardiovascular disease.

Dr. Simona Sperlongano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Doppler imaging
  • speckle tracking echocardiography
  • myocardial work
  • intracardiac flow dynamics
  • three-dimensional echocardiography
  • stress echocardiography
  • transoesophageal echocardiography
  • contrast echocardiography
  • artificial intelligence

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Published Papers (3 papers)

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Research

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10 pages, 1035 KiB  
Article
Longitudinal Systolic Excursion of the Mitral Annular Plane and Left Ventricular Rotational Mechanics Are Associated in Healthy Adults—Three-Dimensional Speckle-Tracking Echocardiography-Derived Insights from the MAGYAR-Healthy Study
by Attila Nemes, Barbara Bordács, Nóra Ambrus and Csaba Lengyel
J. Clin. Med. 2025, 14(9), 3201; https://doi.org/10.3390/jcm14093201 - 5 May 2025
Viewed by 290
Abstract
Introduction: The rotational mechanics of the left ventricle (LV) play a significant role in maintaining systemic circulation. In clinical practice, three-dimensional speckle-tracking echocardiography (3DSTE) is one of the first methods to be used that is suitable for routine, non-invasive investigations, even in [...] Read more.
Introduction: The rotational mechanics of the left ventricle (LV) play a significant role in maintaining systemic circulation. In clinical practice, three-dimensional speckle-tracking echocardiography (3DSTE) is one of the first methods to be used that is suitable for routine, non-invasive investigations, even in healthy individuals, allowing the conduction of extensive but easily feasible tests. In routine clinical practice, mitral annular plane systolic excursion (MAPSE) is used as an easy-to-implement parameter to judge the systolic longitudinal function of the LV; its prognostic significance is also clarified. The relationship between 3DSTE-derived LV rotational mechanics and MAPSE determined by M-mode echocardiography has never been assessed. Therefore, the aim of the present study was to investigate it extensively in healthy adults. Methods: The present study consisted of 108 healthy adult volunteers (mean age 28.1 ± 6.3 years, 50 men). Complete two-dimensional Doppler echocardiography with MAPSE measurements and 3DSTE-derived assessment of LV rotational parameters were performed in all cases. Results: Both the apical and basal LV rotations and the consequential LV twist showed trends toward increase, with increasing MAPSE resulting in the LV twist being largest when the MAPSE was largest. While reduced basal LV rotation was associated with reduced MAPSE, a further increase in MAPSE with increasing basal LV rotation could not be demonstrated. With an increase in apical LV rotation, a trend toward an increase in MAPSE was seen, and was largest when the apical LV rotation was largest. No correlations could be demonstrated between MAPSE and basal LV rotation and apical LV rotation. Conclusions: Associations between LV longitudinal shortening, represented by MAPSE, and LV rotational mechanics could be demonstrated in healthy adults. These findings could have implications for assessing LV function in early disease states. Full article
(This article belongs to the Special Issue Advances in Echocardiography and Its Clinical Applications)
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13 pages, 897 KiB  
Article
One-Year Echocardiographic Follow-Up in Transthyretin Cardiac Amyloidosis: Impact of Tafamidis Treatment
by Davide Restelli, Céline Van Wallendael, Nils De Marneffe, François Damas, Raluca Dulgheru and Patrizio Lancellotti
J. Clin. Med. 2025, 14(5), 1538; https://doi.org/10.3390/jcm14051538 - 25 Feb 2025
Viewed by 543
Abstract
Background/Objectives: Cardiac amyloidosis (CA) is a rare and severe multisystem disorder, associated with an average survival of approximately five years. Recently, Tafamidis has emerged as a promising treatment for transthyretin-related CA. This retrospective study aimed to assess disease progression through echocardiographic findings [...] Read more.
Background/Objectives: Cardiac amyloidosis (CA) is a rare and severe multisystem disorder, associated with an average survival of approximately five years. Recently, Tafamidis has emerged as a promising treatment for transthyretin-related CA. This retrospective study aimed to assess disease progression through echocardiographic findings in patients with transthyretin-related CA, with a specific focus on evaluating the impact of Tafamidis in a cohort managed at our Cardiomyopathy Clinic. Methods: A total of 39 patients were included, of whom 28 received Tafamidis treatment, while 11 did not. Clinical, electrocardiographic, echocardiographic, biological, and other imaging data were collected at diagnosis. Comprehensive echocardiographic data were collected every six months over a two-year period (2021–2023). Results: At 1-year follow-up, the Tafamidis-treated cohort demonstrated stable global systolic and diastolic function. Left ventricular (LV) global longitudinal strain (GLS) and global work index (GWI) showed minimal change (GLS −12.9% (−15.6; −10.7) vs. −13.0% (−14.0; −10.7), p = 0.054; GWI 1113 mmHg/% (963; 1301) vs. 1208 mmHg/% (850; 1420), p = 0.054), and there was no significant increase in indexed LV mass (135.0 g/m2 (118.0; 167.0) vs. 148.0 (128.0; 173.0), p = 0.25). Similarly, valvular heart disease severity remained unchanged. Longitudinal analysis using generalized linear mixed models further confirmed the stability of echocardiographic parameters over the 2-year follow-up period. Systolic function metrics, including LV ejection fraction (slope: −0.0098 ± 0.011, p = 0.38) and GLS (slope: 0.0036 ± 0.0041, p = 0.39) showed no significant decline. Diastolic function assessed through E/A ratio (slope: −0.0007 ± 0.0013, p = 0.59) and E/e’ (slope: −0.0042 ± 0.0073, p = 0.57) also remained stable. Indexed LV mass exhibited no significant progression (slope: 0.050 ± 0.061, p = 0.41). These findings were consistent across the various subgroups. Conclusions: Tafamidis appears to effectively stabilize transthyretin-related CA, limiting disease progression over the follow-up period. Full article
(This article belongs to the Special Issue Advances in Echocardiography and Its Clinical Applications)
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Review

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20 pages, 13554 KiB  
Review
The Role of Trans-Oesophageal Echocardiography in the Interventional Cardiology of Adult Congenital Heart Diseases
by Mario Giordano, Giancarlo Scognamiglio, Gianpiero Gaio, Raffaella Marzullo, Michela Palma, Rosaria Barracano, Flavia Fusco, Nunzia Borrelli, Simona Sperlongano, Giovanni Cimmino, Maria Giovanna Russo and Berardo Sarubbi
J. Clin. Med. 2025, 14(4), 1049; https://doi.org/10.3390/jcm14041049 - 7 Feb 2025
Viewed by 627
Abstract
Advances in interventional cardiology have significantly broadened the range of congenital heart diseases (CHDs) amenable to trans-catheter interventions. Trans-oesophageal echocardiography (TOE) plays a pivotal role as a procedural guide in several percutaneous treatments. Enhanced imaging modalities and technological innovations in echocardiography have refined [...] Read more.
Advances in interventional cardiology have significantly broadened the range of congenital heart diseases (CHDs) amenable to trans-catheter interventions. Trans-oesophageal echocardiography (TOE) plays a pivotal role as a procedural guide in several percutaneous treatments. Enhanced imaging modalities and technological innovations in echocardiography have refined the precision and applicability of these approaches. This review explores the role, impact, and advancements of TOE in trans-catheter treatments for adult CHDs, including both common procedures (e.g., atrial septal defect closure, ventricular septal defect closure) and less frequent interventions (e.g., Mustard/Senning baffle leak closure, Fontan conduit fenestration, ruptured sinus of Valsalva embolization). Full article
(This article belongs to the Special Issue Advances in Echocardiography and Its Clinical Applications)
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