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Clinical Practice Guidelines for the Diagnosis, Treatment and Management of Breast Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Guidelines".

Deadline for manuscript submissions: closed (30 August 2024) | Viewed by 6860

Special Issue Editors


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Guest Editor
1. Department of Medicine, Academy of Applied Medical and Social Sciences, 2 Lotnicza Street, 82-300 Elblag, Poland
2. Department of General Surgery and Surgical Oncology, Saint Wojciech Hospital, Nicolaus Copernicus Health Center, 50 Jana Pawła II Street, 80-462 Gdansk, Poland
Interests: gastric cancer; robotic surgery; Surgical oncology; colorectal surgery; gastrointestinal surgery; minimally invasive surgery; histopathological aspects; signet ring cells; lymphadenectomy; molecular classifications; peritoneal spreading; neoadjuvant chemotherapy; esophageal cancer; achalasia; gastro-esophageal reflux disease; immunonutrition in cancer patients; textbook outcomes and volumes in surgery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy
Interests: abdominoplasty; breast cancer; breast reconstruction

Special Issue Information

Dear Colleagues,

Breast cancer is a significant health issue worldwide, and clinical practice guidelines (CPGs) for its diagnosis, treatment and management play a critical role in improving patient outcomes. This Special Issue aims to reflect on the current status of research on breast cancer CPGs, identify the core problems to be solved and promote the development and dissemination of evidence-based CPGs.

This Special Issue will cover a broad range of topics, including the development and evaluation of breast cancer CPGs, the impact of CPGs on patient outcomes and the challenges of implementing CPGs in clinical practice. The articles included in the issue need to provide insights into the current state of breast cancer CPGs, including their strengths and limitations, and highlight areas for improvement.

The main goal of this Special Issue is to raise awareness of the importance of evidence-based CPGs in breast cancer diagnosis, treatment and management. It will provide an opportunity for researchers, clinicians and patients to collaborate and share knowledge to improve the quality of breast cancer care.

Overall, this Special Issue on Clinical Practice Guidelines for the Diagnosis, Treatment and Management of Breast Cancer will be a valuable resource for healthcare professionals and stakeholders involved in breast cancer care. It will provide a comprehensive overview of the current state of breast cancer CPGs and highlight the need for ongoing research and collaboration to improve patient outcomes.

Dr. Roberto Cuomo
Dr. Luigi Marano
Dr. Donato Casella
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • clinical practice guideline
  • diagnosis
  • treatment
  • management

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Published Papers (3 papers)

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Research

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10 pages, 950 KiB  
Article
Impact of the Prepectoral Breast Reconstruction Assessment Score on Expander-Based Reconstruction Success
by Federico Lo Torto, Gianmarco Turriziani, Sara Carella, Alessia Pagnotta and Diego Ribuffo
J. Clin. Med. 2024, 13(21), 6466; https://doi.org/10.3390/jcm13216466 - 28 Oct 2024
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Abstract
Background/Objectives: The rising incidence of breast cancer has led to more mastectomies and increased demand for reconstruction. While retropectoral reconstruction with expanders is common, it has complications like postoperative pain and animation deformity. Prepectoral reconstruction, aided by advancements in biological and synthetic [...] Read more.
Background/Objectives: The rising incidence of breast cancer has led to more mastectomies and increased demand for reconstruction. While retropectoral reconstruction with expanders is common, it has complications like postoperative pain and animation deformity. Prepectoral reconstruction, aided by advancements in biological and synthetic meshes, offers a promising alternative. Methods: This study prospectively evaluated the “Prepectoral Breast Reconstruction Assessment Score” on 20 patients undergoing mastectomy at Policlinico Umberto I, Rome, from July 2022 to February 2024. Patients with scores between 5 and 8 were included. The procedure involved the use of ADM (Acellular Dermal Matrix) or titanium-coated polypropylene mesh, followed by postoperative expansions and final implant placement after six months. Results: The mean age of patients was 51.85 years, with a mean BMI of 24.145 kg/m2. ADM was used in 15 cases and synthetic mesh in 5. Complications were one exposure of the expander, one superficial skin necrosis and one seroma. Statistical analysis showed a trend toward fewer complications with higher scores, though this was not statistically significant (p-value = 0.139). Conclusions: Prepectoral reconstruction with expanders is a viable option, offering benefits such as reduced operating time, better volume control, and a more natural breast contour compared to the retropectoral approach. Although the trend suggests fewer complications with higher assessment scores, further studies with larger samples are needed for confirmation. Full article
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13 pages, 409 KiB  
Article
Surgical Management and Its Impact on Adjuvant Treatment in Recurrent Ipsilateral Breast Cancer: A Retrospective Cohort Study
by Ines Torras, Isaac Cebrecos, Helena Castillo, Laura Rodríguez, Pablo Zaragoza-Ballester, Carla Sitges, Ignacio Loinaz, Marta Garcia, Meritxell Molla, Sergi Vidal-Sicart and Eduard Mension
J. Clin. Med. 2024, 13(17), 5142; https://doi.org/10.3390/jcm13175142 - 29 Aug 2024
Viewed by 1341
Abstract
Background: Breast cancer (BC) recurrence, defined as the reappearance of cancer in the ipsilateral breast after primary treatment, poses significant challenges in clinical management. Despite advances in treatment, recurrence rates persist, ranging from 0.6 to 1.5% annually, reaching 10–15% at 20 years. This [...] Read more.
Background: Breast cancer (BC) recurrence, defined as the reappearance of cancer in the ipsilateral breast after primary treatment, poses significant challenges in clinical management. Despite advances in treatment, recurrence rates persist, ranging from 0.6 to 1.5% annually, reaching 10–15% at 20 years. This study aims to analyze the surgical and oncological characteristics of patients with BC recurrence. Methods: This retrospective study includes 56 patients diagnosed with recurrent BC between October 2018 and April 2022. Data were collected from a prospectively maintained surgical database. A descriptive analysis was performed on the initial BC, and the recurrence, including surgical complications, was classified using the Clavien–Dindo system. The success rates of selective sentinel lymph node (SLN) biopsies and aberrant drainages were assessed based on previous surgeries. Results: The cohort included 55 females and 1 male, with a median age of 65.3 years. The mean time to BC recurrence was 11.5 years. Among them, 26.8% underwent breast-conserving surgery, 41.1% had a mastectomy, 21.4% had a mastectomy with reconstruction, and 10.7% had an excision over a previous mastectomy. An SLN biopsy was performed in 78.6% of cases, with higher success rates in those without a previous axillary lymph node dissection (85.7% vs. 63.2%). Aberrant drainage was more frequent in patients with a previous ALND (44.4% vs. 20%). The median follow-up was 41.3 months, with 10.7% experiencing a second recurrence. Conclusions: Repeat breast-conserving surgery with re-irradiation for ipsilateral recurrence is feasible and does not significantly increase complications. SLN biopsy is valuable for restaging and tailoring adjuvant therapies, with ALND not being necessary if re-SLN biopsy shows no drainage. The management of aberrant drainage remains controversial. Full article
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Review

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14 pages, 1815 KiB  
Review
Current Trends and Beyond Conventional Approaches: Advancements in Breast Cancer Surgery through Three-Dimensional Imaging, Virtual Reality, Augmented Reality, and the Emerging Metaverse
by Weronika Magdalena Żydowicz, Jaroslaw Skokowski, Luigi Marano and Karol Polom
J. Clin. Med. 2024, 13(3), 915; https://doi.org/10.3390/jcm13030915 - 5 Feb 2024
Cited by 11 | Viewed by 3661
Abstract
Breast cancer stands as the most prevalent cancer globally, necessitating comprehensive care. A multidisciplinary approach proves crucial for precise diagnosis and treatment, ultimately leading to effective disease management. While surgical interventions continue to evolve and remain integral for curative treatment, imaging assumes a [...] Read more.
Breast cancer stands as the most prevalent cancer globally, necessitating comprehensive care. A multidisciplinary approach proves crucial for precise diagnosis and treatment, ultimately leading to effective disease management. While surgical interventions continue to evolve and remain integral for curative treatment, imaging assumes a fundamental role in breast cancer detection. Advanced imaging techniques not only facilitate improved diagnosis but also contribute significantly to the overall enhancement of breast cancer management. This review article aims to provide an overview of innovative technologies such as virtual reality, augmented reality, and three-dimensional imaging, utilized in the medical field to elevate the diagnosis and treatment of breast cancer. Additionally, the article delves into an emerging technology known as the metaverse, still under development. Through the analysis of impactful research and comparison of their findings, this study offers valuable insights into the advantages of each innovative technique. The goal is to provide physicians, surgeons, and radiologists with information on how to enhance breast cancer management. Full article
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