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Clinical Advances in Cardiovascular Interventions
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Clinical Advances in Cardiovascular Interventions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 4420

Special Issue Editor

Dr. Tomasz Tokarek

E-Mail Website
Guest Editor
1. Center for Invasive Cardiology, Electrotherapy and Angiology, Kilinskiego 68, Nowy Sacz, Poland
2. Center for Innovative Medical Education, Jagiellonian University Medical College, Medyczna 9, Krakow, Poland
Interests: coronary artery disease; myocardial infarction; heart failure; atrial fibrillation; aortic stenosis; transcatheter aortic valve disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases are still a major cause of morbidity and mortality throughout the world. To address the rising burden of cardiovascular diseases, we would like to encourage researchers and clinicians alike to submit their pivotal studies on advances in cardiovascular interventions.

It is our great privilege to invite you to contribute to this Special Issue. We aim to publish well-designed studies that can exert a high level of impact on the evidence base of cardiovascular diseases. The long-term goal of this Special Issue is to a create scientific environment able to create studies exploring current clinical practice in percutaneous coronary interventions, valvular heart diseases, arrhythmias, and other cardiovascular interventions. Additionally, and equally important, consideration will be given to studies that focus on new techniques and methods used in the diverse array of cardiovascular interventions.

We aim to publish ground-breaking research articles of significant clinical and scientific value, including observational studies, clinical trials, and review articles. Unique clinical cases, particularly supported by advanced imaging, are also welcome.

Dr. Tomasz Tokarek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary artery disease
  • myocardial infarction
  • cardiovascular imaging
  • microvascular disease
  • heart failure
  • atrial fibrillation
  • ventricular arrhythmias
  • cardiac implantable electronic device
  • valvular heart disease and treatment
  • peripheral arterial disease

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Published Papers (5 papers)

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Research

13 pages, 241 KiB  
Article
What Increases Smokers’ Stress? Degree of Nicotine Dependence and Motivation to Quit Smoking in People After Myocardial Infarction
by Robert Jan Łuczyk, Anna Ślifirczyk, Weronika Sieńska, Marta Łuczyk, Monika Baryła-Matejczuk, Kamil Sikora, Agnieszka Wawryniuk and Katarzyna Sawicka
J. Clin. Med. 2025, 14(5), 1545; https://doi.org/10.3390/jcm14051545 - 25 Feb 2025
Viewed by 451
Abstract
Background: Myocardial infarction (MI) represents one of the major causes of hospitalization in cardiology departments, while tobacco smoking remains a significant public health challenge in Europe. Therefore, there is a pressing need to study this phenomenon in order to undertake preventive actions [...] Read more.
Background: Myocardial infarction (MI) represents one of the major causes of hospitalization in cardiology departments, while tobacco smoking remains a significant public health challenge in Europe. Therefore, there is a pressing need to study this phenomenon in order to undertake preventive actions and thereby reduce the number of people smoking tobacco and, consequently reducing the rate of morbidity and disease. This study aims to assess the factors that increase stress and examine the strategies for coping with stress, nicotine addiction, and the motivation to quit smoking among patients after myocardial infarction. Methods: We analyzed 100 post-MI patients using a sociodemographic questionnaire, the Schneider Smoking Cessation Motivation Test, the Fagerstrom Test for Nicotine Dependence, and the Mini-COPE questionnaire. Results: A sense of helplessness emerged as the primary stress trigger (p = 0.012), with job loss, workplace issues, illness, family death, and relationship problems (p < 0.001) as key stressors. Post-MI patients showed a high degree of smoking cessation motivation, this was enhanced by limited cigarette access and social support. Patients primarily used self-distraction and behavioral disengagement (p < 0.001) as coping mechanisms. A higher degree of nicotine tolerance (rho = −0.355; p < 0.00) and increased stress frequency (rho = −0.169; p = 0.093) correlated negatively with cessation motivation. Conclusions: Post-MI patients demonstrate significant stress-related helplessness, particularly within the professional, family, and relationship domains. The prevalence of coping mechanisms centred around avoidance suggests the need for targeted psychological interventions in this population. Full article
(This article belongs to the Special Issue Clinical Advances in Cardiovascular Interventions)
11 pages, 888 KiB  
Article
Periprocedural Use of Heparin and Other Factors Contributing to the Patency of the Radial Artery Following Diagnostic Coronary Angiography
by Tomasz Bochenek, Adam Pytlewski, Michał Lelek, Bartosz Gruchlik, Jan Szczogiel, Marek Grabka, Andrzej Jaklik, Maciej Podolski and Katarzyna Mizia-Stec
J. Clin. Med. 2025, 14(5), 1401; https://doi.org/10.3390/jcm14051401 - 20 Feb 2025
Viewed by 373
Abstract
Background: Diagnostic angiography of coronary arteries is one of the most common procedures in invasive cardiology and is mainly performed via the radial artery. Rapid improvements in the quality of the equipment and operator’s experience have changed the landscape of this procedure. Methods: [...] Read more.
Background: Diagnostic angiography of coronary arteries is one of the most common procedures in invasive cardiology and is mainly performed via the radial artery. Rapid improvements in the quality of the equipment and operator’s experience have changed the landscape of this procedure. Methods: In this study, 284 patients were analyzed to determine whether heparin administration should be a necessity for all patients to prevent radial artery occlusion (RAO). Moreover, the possible influence of 51 other factors on RAO was analyzed. Results: This study revealed that heparin administration does not have a significant impact on RAO incidence (p = 0.131). However, it was found that a longer fluoroscopy time (p < 0.001) and smaller (5F) vascular sheath (p = 0.001) might serve as protective factors against RAO. On the other hand, a greater number of catheters (p < 0.001), greater compression time (p = 0.001), wider (6F) vascular sheath (p = 0.002), spasm occurrence (p = 0.001), spasmolytic administration (p < 0.001) and atherosclerotic changes in the radial artery (p = 0.005) were risk factors for RAO. Conclusions: This study demonstrates the need for a more personalized approach to the patient when analyzing the individual risk of RAO. In our opinion, it is possible to omit heparin in cases of patients with an initial low risk of RAO or possible adverse drug reactions during diagnostic angiography. Full article
(This article belongs to the Special Issue Clinical Advances in Cardiovascular Interventions)
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13 pages, 1325 KiB  
Article
Evolution of Coagulation and Platelet Activation Markers After Transcatheter Edge-to-Edge Mitral Valve Repair
by Sandra Hadjadj, Jonathan Beaudoin, Frédéric Beaupré, Caroline Gravel, Ons Marsit, Sylvain Pouliot, Benoit J. Arsenault, Philippe Pibarot, Julio Farjat-Pasos, Jorge Nuche-Berenguer, Benoît M-Labbé, Kim O’Connor, Mathieu Bernier, Erwan Salaun, Josep Rodés-Cabau and Jean-Michel Paradis
J. Clin. Med. 2025, 14(3), 831; https://doi.org/10.3390/jcm14030831 - 27 Jan 2025
Viewed by 649
Abstract
Background/Objectives: The recommendations for antithrombotic therapy after transcatheter edge-to-edge mitral valve repair (TEER) are empirical, and the benefit of antiplatelet (APT) or anticoagulation therapy (ACT) remains undetermined. The study sought to investigate the degree and the timing of coagulation and platelet marker activation [...] Read more.
Background/Objectives: The recommendations for antithrombotic therapy after transcatheter edge-to-edge mitral valve repair (TEER) are empirical, and the benefit of antiplatelet (APT) or anticoagulation therapy (ACT) remains undetermined. The study sought to investigate the degree and the timing of coagulation and platelet marker activation after TEER. Methods: This was a prospective study including 46 patients undergoing TEER. The markers of coagulation activation, namely prothrombin fragment 1 + 2 (F1 + 2) and thrombin-antithrombin III (TAT), and the markers of platelet activation, namely soluble P-Selectin and soluble CD-40 ligand (sCD40L), were measured at baseline, 24 h, 1 month, and 1 year after TEER. Results: At discharge, 20 (43%) patients received APT (single: 16, dual: 4), 24 (52%) received ACT, and 2 (4%) had both single APT and ACT. Levels of F1 + 2 and TAT significantly increased at 24 h post TEER (both p < 0.001), rapidly returning to baseline levels at 1 month. However, levels of F1 + 2 and TAT remained higher at 1 month in patients without ACT compared to patients with ACT (respectively, 303.1 vs. 148.1 pmol/L; p < 0.001 and 4.6 vs. 3.0 µg/L; p = 0.020), with a similar trend at 1 year. Levels of soluble P-selectin and sCD40L remained stable at all times after TEER (respectively, p = 0.071 and p = 0.056), regardless of the APT. Conclusions: TEER is associated with an acute activation of the coagulation system, with no increase in platelet activation markers. Hence, the use of dual APT is questionable in this population. Our results raise the hypothesis that the optimal antithrombotic therapy after TEER could be short-term ACT over APT. Further larger studies are warranted. Full article
(This article belongs to the Special Issue Clinical Advances in Cardiovascular Interventions)
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12 pages, 1173 KiB  
Article
Percutaneous Atrial Septostomy in Adult Patients on Veno-Arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock: A Canadian Single-Center Experience
by Nidal El Yamani, Siddhartha Mengi, Mario Sénéchal, Eric Charbonneau, Maxime Laflamme, Julio Farjat-Pasos, Josep Rodés-Cabau and Jean-Michel Paradis
J. Clin. Med. 2024, 13(23), 7433; https://doi.org/10.3390/jcm13237433 - 6 Dec 2024
Viewed by 1054
Abstract
Background/Objectives: Patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) frequently develop left ventricular (LV) distension and pulmonary edema due to an increased LV afterload. A balloon atrial septostomy (BAS) is a technique used to alleviate LV pressure and facilitate left atrial [...] Read more.
Background/Objectives: Patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) frequently develop left ventricular (LV) distension and pulmonary edema due to an increased LV afterload. A balloon atrial septostomy (BAS) is a technique used to alleviate LV pressure and facilitate left atrial decompression. While primarily performed in pediatric populations, this procedure’s feasibility in adult patients is less studied. This study aimed to evaluate the procedural outcomes, including the safety and effectiveness, of BASs in adult patients with cardiogenic shock supported by VA-ECMO. Methods: This single-center retrospective study included 11 adult patients with cardiogenic shock on VA-ECMO, who underwent a BAS between 2012 and 2023. Multiple parameters were used to evaluate the global clinical impact of a BAS on patients with cardiogenic shock. Results: Between 2012 and 2023, 11 patients with cardiogenic shock on VA-ECMO underwent a BAS procedure in our institution. The mean time from the BAS to advanced therapy was 6.4 days. Procedural success was achieved in all patients with no complications. Nine patients (82%) had an improvement in PaO2/FiO2 24 h post-BAS procedure. All patients had an improvement in the pulmonary edema on the chest X-ray 24 to 48 h after the procedure, with clear radiography achieved in nine patients (82%) in a mean time of 7 days (range: 1.5–13 days). A total of five patients (45%) had in-hospital mortality due to non-procedural complications and the mortality timing from BAS was between 5 to 23 days. Among those discharged, all six patients were alive at the 1-year follow-up. Conclusions: A BAS is a feasible and safe technique for decompressing the left atrium in adult patients on VA-ECMO. It significantly improved pulmonary edema and oxygenation in most cases. Further studies with larger populations are needed to evaluate its impact on long-term outcomes. Full article
(This article belongs to the Special Issue Clinical Advances in Cardiovascular Interventions)
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11 pages, 1762 KiB  
Article
Long-Term Mortality after Transcatheter Edge-to-Edge Mitral Valve Repair Significantly Decreased over the Last Decade: Comparison between Initial and Current Experience from the MiTra Ulm Registry
by Nicoleta Nita, Marijana Tadic, Johannes Mörike, Michael Paukovitsch, Dominik Felbel, Mirjam Keßler, Matthias Gröger, Leonhard-Moritz Schneider and Wolfgang Rottbauer
J. Clin. Med. 2024, 13(8), 2172; https://doi.org/10.3390/jcm13082172 - 10 Apr 2024
Cited by 1 | Viewed by 1231
Abstract
(1) Objective: We aimed to assess whether the candidate profile, the long-term outcomes and the predictors for long-term mortality after transcatheter edge-to-edge mitral valve repair (M-TEER) have changed over the last decade; (2) Methods: Long-term follow-up data (median time of 1202 [...] Read more.
(1) Objective: We aimed to assess whether the candidate profile, the long-term outcomes and the predictors for long-term mortality after transcatheter edge-to-edge mitral valve repair (M-TEER) have changed over the last decade; (2) Methods: Long-term follow-up data (median time of 1202 days) including mortality, MACCE and functional status were available for 677 consecutive patients enrolled in the prospective MiTra Ulm registry from January 2010 to April 2019. The initial 340 patients treated in our institution before January 2016 were compared with the following 337 patients; (3) Results: Patients treated after 2016 showed significantly less ventricular dilatation (left ventricular end-systolic diameter of 43 ± 13 mm vs. 49 ± 16 mm, p < 0.007), lower systolic pulmonary pressures (50 ± 15 mmHg vs. 57 ± 21 mmHg, p = 0.01) and a lower prevalence of severe tricuspid regurgitation (27.2% vs. 47.3%, p < 0.001) at baseline than patients treated before 2016. Compared to the cohort treated before 2016, patients treated afterwards showed a significantly lower all-cause 3-year mortality (29.4% vs. 43.8%, p < 0.001) and lower MACCE (38.6% vs. 54.1%, p < 0.001), without differences for MR etiology. While severe tricuspid regurgitation and NYHA class IV remained independently associated with an increased long-term mortality over the last decade, severe left ventricular dilatation (hazard ratio, HR 2.12, p = 0.047) and severe pulmonary hypertension (HR 2.18, p = 0.047) were predictors of long-term mortality only in patients treated before 2016. (4) Conclusions: The M-TEER candidates are currently treated earlier in the course of disease and benefit significantly in terms of a better long-term survival than patients treated at the beginning of the M-TEER era. Full article
(This article belongs to the Special Issue Clinical Advances in Cardiovascular Interventions)
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