Special Issue "Prognostic and Diagnostic Testing in Onco-Haematological Diseases in the Era of Novel Therapies: Updates and Perspectives"

Dear Colleagues,

The last decade has been characterized by a progressive shift in the treatment of onco-hematological malignancies from conventional radio- and chemotherapy to innovative and more personalized therapies, including those based on chimeric antigen receptor (CAR) T cells, bispecific T-cell engagers (BiTEs), and antibody–drug conjugates (ADCs). As a result, many patients achieve responses, including complete radiographical or pathological remission, thus implying that sensitive techniques need to be implemented to monitor minimal residual disease (MRD). Additionally, there is a need to assess whether the prognostic biomarkers and risk scoring systems that have been validated mainly in the chemo-immunotherapy era retain significance in the context of innovative and more personalized therapies.

For this to be conceivable, novel diagnostic and prognostic testing modalities have been developed mainly based on next-generation sequencing, digital droplet PCR, mass cytometry, and digital imaging to study both the tumor and the tumor microenvironment. Considerable data indicate, in fact, that the immune landscape of hematological malignancies defined through the integration of genomic, epigenomic, and transcriptomic data influence anti-tumor immune responses and patient outcomes.

Thus, the aim of this Special Issue is to provide a comprehensive overview of newly developed prognostic and diagnostic approaches and of their use in onco-hematology in the era of novel agents. Original research articles as well as reviews on these topics are welcomed.

Dr. Cristiana Carniti
Guest Editor

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