Treatment and Prevention Strategies for Skin Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 2858

Special Issue Editors


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Guest Editor
Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
Interests: wound healing; cutaneous oncology; epidemiology

E-Mail Website
Guest Editor
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
Interests: Mohs surgery; cutaneous oncology; high risk skin cancers

Special Issue Information

Dear Colleagues,

Skin cancer is the most common malignancy worldwide. There were over 77,000 new cases of melanoma diagnosed in the United States from 2012 to 2016. Nonmelanoma skin cancer (NSMC) is even more prevalent, with estimates of over 5.4 million new cases and over 3.3 million people treated in 2012. The rising incidence is attributed to aging population trends, increased cumulative UV exposure over lifetime, and immunosenescence. It is a public health concern as it is the fifth most costly cancer to treat. As we approach a greater understanding of its pathophysiology, a number of new therapies have emerged, including targeted treatments and immunotherapy. However, the prevention of skin cancer remains imperative, our current understanding being that the environmentally driven UV component of sunlight is the major risk factor. In this Special Issue, we hope to elucidate new treatment and prevention strategies for skin cancer.

Dr. Robert S. Kirsner
Dr. Jennifer C. Tang
Guest Editors

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Keywords

  • basal cell carcinoma
  • squamous cell carcinoma
  • melanoma

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Published Papers (1 paper)

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Research

15 pages, 582 KiB  
Article
The Outcome of Chemotherapy for Metastatic Extramammary Paget’s Disease
by Hiroki Hashimoto, Yumiko Kaku-Ito, Masutaka Furue and Takamichi Ito
J. Clin. Med. 2021, 10(4), 739; https://doi.org/10.3390/jcm10040739 - 12 Feb 2021
Cited by 16 | Viewed by 2425
Abstract
The efficacy and survival impact of conventional chemotherapies for metastatic extramammary Paget’s disease (EMPD) have not been fully elucidated. This study examined the long-term outcome of chemotherapy for this indication. We conducted a retrospective review of 21 patients with distant metastatic EMPD (14 [...] Read more.
The efficacy and survival impact of conventional chemotherapies for metastatic extramammary Paget’s disease (EMPD) have not been fully elucidated. This study examined the long-term outcome of chemotherapy for this indication. We conducted a retrospective review of 21 patients with distant metastatic EMPD (14 patients treated with chemotherapy and 7 patients treated without chemotherapy). The response rate of chemotherapy and patient survival were statistically analyzed. Among the 14 patients treated with chemotherapy, 12, 1, and 1 patient received docetaxel, paclitaxel, and low-dose 5-fluorouracil plus cisplatin, respectively, as the first-line treatment. The response rate was 50.0% (7/14), and the disease control rate was 64.3% (9/14). The median progression-free survival (PFS) and overall survival (OS) were 16.8 and 27.9 months, respectively. Multivariate analyses revealed that chemotherapy was a significant factor for prolonged PFS (hazard ratio (HR) 0.22, p = 0.038) but not for OS (HR = 1.71, p = 0.54). Ten patients (71.4%) had severe (grade 3 or 4) hematological adverse events. Although conventional chemotherapy improved PFS, we failed to show a significantly improved OS. Considering the frequent adverse events of conventional chemotherapy, targeted therapy may become a mainstay for the treatment of metastatic EMPD. Full article
(This article belongs to the Special Issue Treatment and Prevention Strategies for Skin Cancer)
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