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Clinical Updates on Heart Failure and Cardiac Transplantation
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Clinical Updates on Heart Failure and Cardiac Transplantation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1080

Special Issue Editors

Dr. Jasper Iske

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Guest Editor
1. Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charite (DHZC), 13353 Berlin, Germany
2. Charite—Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany
Interests: clinical heart transplantation; age-specific ischemia-reperfusion injury; ex vivo organ perfusion
Dr. Fabio Ius

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Guest Editor
1. Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany
2. German Center for Lung Research, BREATH, Hannover Medical School, 30625 Hannover, Germany
Interests: adult and pediatric heart-lung and lung transplant; ECMO and EVLP in lung transplantation; anti-HLA donor specific antibodies in lung and heart transplantation
Dr. Felix Hennig

E-Mail Website
Guest Editor
1. Department of Cardiothoracic Surgery, Deutsches Herzzentrum der Charite, D-13353 Berlin, Germany
2. Charite—Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, D-10117 Berlin, Germany
Interests: heart and lung transplantation; mechanical circulatory support; ex-vivo organ perfusion

Special Issue Information

Dear Colleagues,

Heart failure remains a significant global health burden, demanding the continuous refinement of diagnostic approaches, therapeutic strategies, and patient care paradigms. Moreover, cardiac transplantation stands as a life-saving intervention for end-stage heart failure patients, but it also presents complex challenges in patient selection, donor allocation, immunosuppressive management, and long-term outcomes.

Through the synthesis of cutting-edge research findings, clinical trial outcomes, and expert perspectives, this Special Issue aims to bridge the gap between evidence-based medicine and clinical practice. We welcome submissions that span various aspects of cardiovascular medicine and aim to delineate diagnostic and therapeutic approaches as well surgical techniques and personalized transplant protocols.

This call for papers presents an opportunity to contribute to a comprehensive exploration of the evolving landscape of cardiovascular medicine, fostering dialogue, collaboration, and ultimately advancements in patient care. We look forward to receiving your submissions and collectively shaping the future of heart failure and cardiac transplantation research.

Dr. Jasper Iske
Dr. Fabio Ius
Dr. Felix Hennig
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart transplantation
  • organ allocation
  • organ preservation
  • ex vivo heart perfusion
  • machine perfusion
  • NMP
  • preservation protocols
  • organ procurement
  • transplant protocol
  • heart transplant rejection

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

13 pages, 1181 KiB  
Article
Implications of Preoperative C-Reactive Protein Levels in Heart Transplant Patients—A Single-Center Retrospective Study
by Laurentiu Huma, Horatiu Suciu, Calin Avram, Radu-Adrian Suteu, Alina Danilesco, Dragos-Florin Baba, Diana-Andreea Moldovan and Anca-Ileana Sin
J. Clin. Med. 2024, 13(23), 7466; https://doi.org/10.3390/jcm13237466 - 8 Dec 2024
Viewed by 745
Abstract
Background: Heart transplant is the final therapeutic option for end-stage heart failure patients. It has been used with increasing success as a surgical procedure, greatly influenced by advances in diagnostic and prognostic tools. The aim of this paper was to study potential [...] Read more.
Background: Heart transplant is the final therapeutic option for end-stage heart failure patients. It has been used with increasing success as a surgical procedure, greatly influenced by advances in diagnostic and prognostic tools. The aim of this paper was to study potential implications of C-reactive protein (CRP) in patients who underwent heart transplants. Methods: Our cohort included 43 adult patients from the Emergency Institute for Cardiovascular Diseases and Transplant of Târgu Mureș who underwent heart transplants in our center between 2011 and 2023. Correlations between CRP levels and different characteristics of the patients were investigated, and the optimal cut-off value for CRP levels in relation to the 6-month mortality rate was determined. The central tendencies of the baseline characteristics of patients who had a CRP value lower than the cut-off and those with a value higher than it were compared using parametric or nonparametric tests. Results: Significant correlations between the preoperative CRP levels and 6-month mortality rate (r = 0.35; 95%CI: 0.05–0.60; p = 0.02), as well as previous cardiac resynchronization therapy (CRT) and preoperative CRP levels (r = −0.37; 95%CI: −0.61–−0.07, p = 0.01) were highlighted. A value for CRP > 1.66 mg/dL was found to be associated with 6-month mortality (OR = 18.00; 95%CI: 1.90–170.33, p < 0.01). Moreover, the patients who received CRT before transplantation had significantly lower levels of CRP when compared to those who did not receive CRT (p = 0.01). Conclusions: Preoperative CRP levels could represent a valuable asset in the follow-up algorithm of heart transplant patients. The lower levels of CRP in patients who benefited from CRT before transplantation highlights the importance of understanding the complex mechanisms of inflammation and increasing focus on device therapy for future transplant recipients. Further prospective studies with larger cohorts are needed for validation. Full article
(This article belongs to the Special Issue Clinical Updates on Heart Failure and Cardiac Transplantation)
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