Advances in the Surgical Management of Gynecological Malignancies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2179

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania
Interests: gynaecological surgery; gynecologic oncology; hysterectomy
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Guest Editor
Department of Surgery, Discipline of Surgical Semiology II, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
Interests: breast cancer; laparoscopic surgery; gynecological surgery

Special Issue Information

Dear Colleagues,

Advances in the surgical management of gynecological malignancies have revolutionized treatment approaches, enhancing both survival rates and quality of life for patients. With innovative techniques and technologies, surgeons can now offer more precise and less invasive procedures tailored to individual cases.

Minimally invasive surgery, including laparoscopy and robotic-assisted surgery, has become increasingly popular. These techniques enable surgeons to perform complex procedures with smaller incisions, reducing pain, blood loss, and recovery time. Additionally, they allow for better visualization and manipulation of tissues, leading to improved outcomes.

Furthermore, advances in imaging modalities such as MRI and PET-CT have enhanced preoperative planning and staging accuracy, enabling surgeons to better assess tumor extent and plan surgical approaches accordingly. This has led to more personalized treatment strategies and improved patient outcomes.

In addition to surgical techniques, there have been significant developments in adjuvant therapies such as targeted therapies and immunotherapy, which can be combined with surgery to achieve better results, particularly in advanced or recurrent cases.

Overall, these advances represent a paradigm shift in the management of gynecological malignancies, offering patients new hope and improved prospects for long-term survival and quality of life. As research continues and technology evolves, the future of surgical oncology holds even more promise for further enhancing patient care.

Prof. Dr. Laurentiu Pirtea
Dr. Răzvan Ştefan Ilina
Guest Editors

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Keywords

  • minimally invasive surgery
  • laparoscopy surgery
  • robotic-assisted surgery
  • gynecological malignancies

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Published Papers (1 paper)

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Review

22 pages, 1003 KiB  
Review
Comprehensive Review of Endometrial Cancer: New Molecular and FIGO Classification and Recent Treatment Changes
by Maria-Bianca Anca-Stanciu, Andrei Manu, Maria Victoria Olinca, Cătălin Coroleucă, Diana-Elena Comandașu, Ciprian Andrei Coroleuca, Calina Maier and Elvira Bratila
J. Clin. Med. 2025, 14(4), 1385; https://doi.org/10.3390/jcm14041385 - 19 Feb 2025
Viewed by 1771
Abstract
Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with rising incidence due to aging populations and obesity-related factors. This review explores the evolving molecular and FIGO classifications of EC, highlighting their significance in diagnosis, prognosis, and personalized treatment strategies. [...] Read more.
Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with rising incidence due to aging populations and obesity-related factors. This review explores the evolving molecular and FIGO classifications of EC, highlighting their significance in diagnosis, prognosis, and personalized treatment strategies. Molecular subtyping based on The Cancer Genome Atlas (TCGA) classification offers a more precise understanding of EC, dividing it into POLE ultramutated, microsatellite instability-high (MSI-H), copy-number low (CNL), and copy-number high (CNH) subtypes. Each subgroup has distinct genetic, histological, and prognostic characteristics. Recent updates to the FIGO staging system incorporate molecular features, allowing for more tailored treatment approaches. Advances in immunotherapy, targeted therapies, and novel therapeutic combinations have reshaped clinical management. This review emphasizes the integration of molecular diagnostics into routine practice, outlining challenges and future perspectives in managing EC for improved patient outcomes. Full article
(This article belongs to the Special Issue Advances in the Surgical Management of Gynecological Malignancies)
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