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Diagnosis and Treatment of Brain Tumor

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 4155

Special Issue Editor


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Guest Editor
Department of Neurosurgery, Shimane Prefectural Central Hospital, 4-1-1 Himebara, Izumo, Shimane 693-8555, Japan
Interests: neurosurgery; cerebral aneurysms; acute ischemic stroke; endovascular treatment
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Special Issue Information

Dear Colleagues,

In recent years, advances in computer technology have led to dramatic advancements in diagnostic imaging, preoperative simulation, and intraoperative monitoring. In addition, genetic diagnosis and classification of gliomas have been further developed, and thus, outcomes can now be better predicted. Therefore, in order to collate the findings and insights of physicians and researchers and to help them in their future research, we aim to launch this Special Issue which will provide an update of the recent advancements in various aspects of brain tumors.

Prof. Dr. Fusao Ikawa
Guest Editor

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Keywords

  • breakthroughs in brain tumor treatment
  • novel therapies and drug development of brain tumor
  • Indication and outcome of brain tumor surgery
  • anatomy, imaging, and monitoring of brain tumor
  • early detection and diagnostics of brain tumor
  • personalized medicine in oncology of brain tumor
  • brain tumor genetics and biomarkers
  • supportive care for brain tumor patients
  • survivorship and quality of life
  • epidemiology in brain tumor

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Published Papers (3 papers)

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Research

11 pages, 986 KiB  
Article
Surgical Outcomes following Reoperation for Recurrent Intracranial Meningiomas
by Shunya Hanakita and Soichi Oya
J. Clin. Med. 2024, 13(12), 3356; https://doi.org/10.3390/jcm13123356 - 7 Jun 2024
Viewed by 888
Abstract
Background: We sometimes encounter refractory meningioma cases that are difficult to control, even after achieving a high resection rate or following radiation therapy (RT). In such cases, additional surgical resection might be attempted, but reports regarding outcomes of re-do surgery for recurrent meningiomas [...] Read more.
Background: We sometimes encounter refractory meningioma cases that are difficult to control, even after achieving a high resection rate or following radiation therapy (RT). In such cases, additional surgical resection might be attempted, but reports regarding outcomes of re-do surgery for recurrent meningiomas are scarce. Methods: This study was a retrospective review of patients who underwent re-do surgery for recurrent meningiomas. The risks of re-doing surgery were statistically analyzed. A comparative analysis between the patients who underwent primary surgery for intracranial meningiomas was also performed. Twenty-six patients underwent re-do surgeries for recurrent meningiomas. Results: At first re-do surgery, gross total resection was achieved in 20 patients (77%). The disease-free survival rate after the first re-do surgery was calculated as 73/58/44% at 1, 2, and 5 years, respectively. A significant factor affecting longer disease-free survival was WHO Grade 1 diagnosis at first re-do surgery (p = 0.02). Surgery-related risks were observed in 10 patients presenting a significant risk factor for skull base location (p = 0.04). When comparing with the risk at primary surgery, the risks of surgical site infection (p = 0.04) and significant vessel injury (p < 0.01) were significantly higher for the re-do surgery. Conclusions: Re-do surgery could increase surgery-related risks compared to the primary surgery; however, it could remain a crucial option, while the indication should be carefully examined in each case. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Brain Tumor)
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11 pages, 4328 KiB  
Article
Surgical Risk in Elderly Patients with Meningiomas in Japan
by Fusao Ikawa, Nobuaki Michihata, Soichi Oya, Hideo Yasunaga and Nobutaka Horie
J. Clin. Med. 2024, 13(10), 2882; https://doi.org/10.3390/jcm13102882 - 14 May 2024
Viewed by 1104
Abstract
Background/Objective: No guidelines indicate surgical risk factors for the elderly because of the lack of data from general neurosurgeons. To better understand the management of surgical risk in elderly patients with meningiomas based on a national database in Japan. Methods: Results [...] Read more.
Background/Objective: No guidelines indicate surgical risk factors for the elderly because of the lack of data from general neurosurgeons. To better understand the management of surgical risk in elderly patients with meningiomas based on a national database in Japan. Methods: Results of surgically treated meningiomas were explored in 8138 patients registered in the Diagnosis Procedure Combination database in Japan during 2010–2015. Age (<65, 65–74, and ≥75 years), sex, Barthel index (BI), medical history, tumor location, oral medication prescriptions on admission, and stroke complications were evaluated. Multivariate logistic regression analysis identified risk factors for stroke complications, BI deterioration between admission and discharge, and in-hospital mortality. Results: Advanced age was the prominent risk factor for BI deterioration (odds ratio: 3.26; 95% confidence interval: 2.69–3.95) but not for in-hospital mortality. Lower BI (60–80) on admission increased the risk of BI deterioration in all age groups; however, BI < 60 demonstrated a significant inverse risk (0.47; 0.32–0.69) in the elderly (≥75 years). Location (falx, parasagittal, and deep) and anticoagulants were not significant risk factors for BI deterioration in patients aged ≥ 75 years, despite being significant risk factors in patients aged <65 and/or 65–74 years. Conclusions: Although advanced age could lead to postoperative functional decline at discharge, it was not sufficiently significant enough to be associated with in-hospital mortality. Because of the possibility of recovery even in elderly patients with severe disabilities, appropriate surgical selection and optimal management may lead to favorable functional outcomes in elderly patients with meningiomas. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Brain Tumor)
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11 pages, 885 KiB  
Article
Angiographic Evaluation of the Feeding Artery in Skull Base Meningioma
by Hironori Arima, Yusuke Watanabe, Yuta Tanoue, Hiroki Morisako, Taichiro Kawakami, Tsutomu Ichinose and Takeo Goto
J. Clin. Med. 2023, 12(24), 7717; https://doi.org/10.3390/jcm12247717 - 15 Dec 2023
Cited by 3 | Viewed by 1774
Abstract
To identify the characteristics of feeding arteries in skull base meningioma including location and prevalence, we evaluated the distributions and types of feeding arteries in skull base meningioma by cerebral angiography and assessed relationships to tumor attachment. We enrolled patients with skull base [...] Read more.
To identify the characteristics of feeding arteries in skull base meningioma including location and prevalence, we evaluated the distributions and types of feeding arteries in skull base meningioma by cerebral angiography and assessed relationships to tumor attachment. We enrolled patients with skull base meningioma who underwent MRI and cerebral digital subtraction angiography (DSA), from September 2015 to October 2022. Subjects comprised 115 patients (32 males, 83 females; mean age, 52.7) with 117 meningiomas, showing tumor attachments around the “cavernous sinus to the upper part of the clivus” (Area 1), “lower part of the clivus to foramen magnum” (Area 2), and “tentorium around the petrous bone” (Area 3). Frequent arteries, such as the dorsal meningeal artery (DMA), the ascending pharyngeal artery (APA), the tentorial artery (TA), and the petrosal branch (PB) of the middle meningeal artery (MMA) were analyzed in terms of their associations with tumor attachment to Areas 1–3. Meningiomas with the DMA as a feeding artery correlated with tumor attachment to Area 1 (p < 0.001). Meningiomas with the APA correlated with tumor attachment to Area 2 (p < 0.001). Meningiomas with the TA correlated with tumor attachment to Area 3 (p < 0.001). The PB correlated with Area 3 (p < 0.05). Our study founded that visualization of these arteries correlated well with specific areas. These arteries were also the main feeders in each type of skull base meningioma. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Brain Tumor)
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