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Fibromyalgia: Updates on Diagnosis and Clinical Management
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Fibromyalgia: Updates on Diagnosis and Clinical Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (21 February 2025) | Viewed by 5266

Special Issue Editors

Prof. Dr. Juan Pablo Hervás-Pérez

E-Mail Website
Guest Editor
1. Faculty of Health Sciences - HM Hospitals, University Camilo José Cela, 28692 Madrid, Spain
2. Instituto de Investigación Sanitaria HM Hospitales, Villanueva de la Cañada, Spain
Interests: chronic pain; nutrition; fibromyalgia; pharmacy; physiotherapy; amperometric biosensors
Dr. Paloma García de la Peña-Lefebvre

E-Mail Website
Guest Editor
1. Faculty of Health Sciences-HM Hospitals, University Camilo José Cela, 28692 Madrid, Spain
2. Instituto de Investigación Sanitaria HM Hospitales, Villanueva de la Cañada, Spain
Interests: connective tissue research; systemic sclerosis and related lung related to rheumatic diseases; teaching

Special Issue Information

Dear Colleagues,

Collaborating as Guest Editors in the Special Issue “Fibromyalgia: Updates on Diagnosis and Clinical Management” is a pleasure for us. Fibromyalgia is a chronic condition characterized by widespread pain, fatigue, sleep disturbances, and functional symptoms. The etiopathogenesis, diagnostic criteria, and classification criteria of fibromyalgia are still debated, leading to varying strategies for treating the condition. Fibromyalgia is the third most frequent musculoskeletal condition, and its prevalence increases with age. Despite improvements in diagnostic criteria, further research is needed to focus on global prevalence, etiology, pathomechanisms, and their implications for further treatment. Interdisciplinary research is crucial for the future and is welcome. Any research group investigating fibromyalgia is encouraged in this new volume of this Special Issue. We invite researchers to contribute with original articles, narrative reviews, systematic reviews, meta-analyses, scoping reviews, or potential hypotheses of potential mechanisms.

Prof. Dr. Juan Pablo Hervás-Pérez
Dr. Paloma García de la Peña-Lefebvre
Guest Editors

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Keywords

  • fibromyalgia
  • chronic fatigue syndrome
  • chronic pain
  • diagnostic biomarkers
  • emerging technologies in fibromyalgia treatment or diagnostics
  • nutrition and fibromyalgia
  • multidisciplinary treatment
  • stress and fibromyalgia

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Published Papers (3 papers)

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13 pages, 2892 KiB  
Article
Diagnostic Accuracy of Neurocognitive and Executive Functions to Discriminate Women With and Without Fibromyalgia Syndrome: A Secondary Analysis
by Margarita Cigarán-Mendez, Juan C. Pacho-Hernández, Ángela Tejera-Alonso, Cristina Gómez-Calero, César Fernández-de-las-Peñas, Juan A. Valera-Calero and Francisco G. Fernández-Palacios
J. Clin. Med. 2024, 13(20), 6195; https://doi.org/10.3390/jcm13206195 - 17 Oct 2024
Viewed by 1215
Abstract
Objective: The aim of the current study was to determine the capability of neurocognitive variables and executive functions to differentiate women with and without fibromyalgia syndrome (FMS). Methods: A secondary diagnostic accuracy analysis was conducted. A battery of neurocognitive and executive function tests [...] Read more.
Objective: The aim of the current study was to determine the capability of neurocognitive variables and executive functions to differentiate women with and without fibromyalgia syndrome (FMS). Methods: A secondary diagnostic accuracy analysis was conducted. A battery of neurocognitive and executive function tests (the D2 Attention test, the Rey-Osterrieth Complex Figure for visual perception, “Digits D/R/I” tests of the WAIS-IV battery for working memory, the 5-Digit test for mental inhibition, the Symbol Search for processing speed, and the Zoo Test for planning/decision-making) were collected in 129 women with FMS and 111 without FMS. The area under the receiver operating characteristic (ROC) curve, optimal cut-off point, sensitivity, specificity, and positive and negative likelihood ratios (LR) for each variable were calculated. Results: Between-group differences were identified in ROCF_Copy (p = 0.043), ROCF_Recall (p = 0.004), d2_TR (p = 0.019), d2_TA (p = 0.007), d2_TOT (p = 0.005), d2_CON (p = 0.004), d2_C (p = 0.042), Symbol Search (p = 0.008), Decoding _FDT (p = 0.001), Retrieving_FDT (p = 0.001), and Inhibiting_FDT (p = 0.024). The result showed that FDT-based outcomes (Retrieving_FDT: ROC 0.739, sensitivity 85.3%, specificity 48.6%; Decoding_FDT: ROC 0.724, sensitivity 50.4%, specificity 16.2%; Inhibiting_FDT: ROC 0.708, sensitivity 56.6%, specificity 22.5%) were the variables able to differentiate between women with and without FMS. Conclusions: Although women with FMS exhibited deficits in attention, long-term visual memory, processing speed, and mental inhibition when compared with women without FMS, only mental inhibition scores showed moderate diagnostic accuracy to discriminate between women with and without FMS. Future studies investigating these results in clinical settings are needed to identify the clinical relevance of these findings. Full article
(This article belongs to the Special Issue Fibromyalgia: Updates on Diagnosis and Clinical Management)
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11 pages, 267 KiB  
Article
The Association between Pressure Pain Thresholds, Conditioned Pain Modulation, Clinical Status, and Sleep Quality in Fibromyalgia Patients: A Clinical Trial Secondary Analysis
by María Elena González-Álvarez, Víctor Riquelme-Aguado, Alberto Arribas-Romano, Josué Fernández-Carnero and Jorge Hugo Villafañe
J. Clin. Med. 2024, 13(16), 4834; https://doi.org/10.3390/jcm13164834 - 16 Aug 2024
Cited by 4 | Viewed by 1796
Abstract
Background: Fibromyalgia (FM) is a complex multidimensional disorder primarily characterized by chronic widespread pain, significantly affecting patients’ quality of life. FM is associated with some clinical signs found with quantitative sensory testing (QST), sleep disturbance, or psychological problems. This study aims to [...] Read more.
Background: Fibromyalgia (FM) is a complex multidimensional disorder primarily characterized by chronic widespread pain, significantly affecting patients’ quality of life. FM is associated with some clinical signs found with quantitative sensory testing (QST), sleep disturbance, or psychological problems. This study aims to explore the associations between pressure pain thresholds (PPTs), conditioned pain modulation (CPM), clinical status, and sleep quality in FM patients, offering insights for better clinical management and assessment tools. Methods: This secondary analysis utilized data from a clinical trial involving 129 FM patients. Various assessments, including the Fibromyalgia Impact Questionnaire (FIQ), Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory (STAI), and Jenkins Sleep Scale (JSS), were employed to evaluate the clinical and psychological status and sleep quality. PPTs and CPM were measured to understand their relationship with clinical parameters. Results: Our findings revealed that PPTs and CPM are not significantly associated with the clinical status or sleep quality of FM patients. Instead, pain catastrophizing and anxiety state showed a stronger correlation with the impact of fibromyalgia and sleep disturbances. These results highlight the importance of psychological and cognitive factors in managing FM. Conclusions: The study suggests that while PPTs and CPM may not be reliable biomarkers for clinical status in FM, the use of comprehensive assessments including FIQ, PCS, STAI, and JSS can provide a more accurate evaluation of patients’ condition. These tools are cost-effective, can be self-administered, and facilitate a holistic approach to FM management, emphasizing the need for personalized treatment plans. Full article
(This article belongs to the Special Issue Fibromyalgia: Updates on Diagnosis and Clinical Management)

Other

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11 pages, 1262 KiB  
Systematic Review
Effect of Pilates on Pain and Health-Related Quality of Life in Fibromyalgia Patients: A Systematic Review and Meta-Analysis
by Chalisa Nithuthorn, Natapohn Chaipichit, Thammasorn Jeeraaumponwat, Mart Maiprasert and Piyameth Dilokthornsakul
J. Clin. Med. 2024, 13(23), 7447; https://doi.org/10.3390/jcm13237447 - 6 Dec 2024
Viewed by 1587
Abstract
Background: Pilates is one of the non-pharmacological interventions for fibromyalgia (FM). However, its impacts on pain and health-related quality of life (HRQOL) in fibromyalgia patients (FMPs) are inconclusive. This study aimed to assess the effects of Pilates on pain and HRQOL among FMPs. [...] Read more.
Background: Pilates is one of the non-pharmacological interventions for fibromyalgia (FM). However, its impacts on pain and health-related quality of life (HRQOL) in fibromyalgia patients (FMPs) are inconclusive. This study aimed to assess the effects of Pilates on pain and HRQOL among FMPs. Methods: A systematic review and meta-analysis were conducted. Four databases—PubMed, ScienceDirect, Scopus, and Cochrane CENTRAL—along with one grey literature source, Google Scholar, were searched for randomized controlled trials comparing Pilates with other exercises or usual care in FMPs. The outcomes were pain and HRQOL. A meta-analysis was performed using a random-effects model. Results: Six studies were included (n = 265). We found that the effects of Pilates from each individual study on pain were inconsistent. Our pooled analysis of visual analog scale (VAS) scores demonstrated significant pain reduction (mean difference (MD), −0.71, 95%CI, −1.33 to −0.10, p = 0.023; (I2 = 29.3%, p = 0.226)). However, neither the algometric score (AS) nor tender point count (TPC) showed an insignificant difference (AS: MD, −0.43, 95%CI, −2.60 to 1.74, p = 0.700; (I2 = 0.0%, p = 0.654); TPC: MD, −0.16, 95%CI, −2.22 to 1.89, p = 0.520; (I2 = 0.0%, p = 0.515)). Regarding HRQOL, Pilates showed statistically significant improvements on the Fibromyalgia Impact Questionnaire (FIQ) (MD, −7.28, 95%CI, (−12.06 to −2.49), p = 0.003; (I2 = 95.7%, p < 0.001)). A sensitivity analysis of three RCTs (n = 176) based on the ACR 2010 supported this finding (MD, −7.68, 95% CI, −8.60 to −6.76, p < 0.001; (I2 = 0.0%, p = 0.832)) with non-important heterogeneity. Conclusions: Pilates may benefit FMPs. It could reduce pain and improve HRQOL. Given the small number of studies and the presence of data heterogeneity, future high-quality RCTs would provide a clearer conclusion. Full article
(This article belongs to the Special Issue Fibromyalgia: Updates on Diagnosis and Clinical Management)
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