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Pulmonary Embolism in 2021 and Beyond
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Pulmonary Embolism in 2021 and Beyond

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 7193

Special Issue Editors

Dr. Marc Laine

E-Mail Website
Guest Editor
1. Service de Cardiologie, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille, 13015 Marseille, France
2. Centre de recherche en CardioVasculaire et Nutrition (C2VN), Faculté des Sciences Médicales et Paramédicales de Marseille, Aix-Marseille Université, INSERM 1263, INRAE 1260, Marseille, France
3. Mediterranean Association for Research and Studies in CARDIOlogy, Marseille, France
Interests: pulmonary embolism; acute coronary syndrome; myocardial infarction; cardiogenic shock; thrombosis
Prof. Dr. Laurent Bonello

E-Mail Website
Guest Editor
Intensive Care Unit, Hopital Universitaire Nord, Chemin des Bourrely, 13015 Marseille, France
Interests: acute coroanry syndrome; cardiogenic shock; left ventricle assist devices; antithrombotic tehrapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With 900,000 patients affected and 100,000 deaths per year in the United States, pulmonary embolism is the third cause of cardiovascular death. Thromboembolic venous disease is a very active field of research, as there is still much progress to be made in the understanding of this protean pathology and its management.

The objective of this special issue entitled "Pulmonary embolism in 2021 and beyond" is to collect a series of original research articles and high-quality review articles with the aim of increasing knowledge about this pathology and improving its management.

We hope that this forward-looking and modern issue will set the stage for the management ofpulmonary embolism as it will be carried out in the coming years. All fields of research will be covered: pulmonary reperfusion strategies (directed catheter thrombolysis and others...), pulmonary embolism response team, diagnostic approach, management of specific populations, predictive medicine, artificial intelligence, basic science…

We trust the expertise and creativity of the authors to make their valuable contribution to this ambitious special issue.

Dr. Marc Laine
Prof. Dr. Laurent Bonello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Pulmonary embolism
  • Pulmonary embolism response team
  • Pulmonary reperfusion
  • Thrombosis
  • Venous thromboembolism

Published Papers (3 papers)

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Research

16 pages, 3309 KiB  
Article
Putative Biomarkers for Acute Pulmonary Embolism in Exhaled Breath Condensate
by Inger Lise Gade, Jacob Gammelgaard Schultz, Rasmus Froberg Brøndum, Benedict Kjærgaard, Jens Erik Nielsen-Kudsk, Asger Andersen, Søren Risom Kristensen and Bent Honoré
J. Clin. Med. 2021, 10(21), 5165; https://doi.org/10.3390/jcm10215165 - 4 Nov 2021
Cited by 2 | Viewed by 2031
Abstract
Current diagnostic markers for pulmonary embolism (PE) are unspecific. We investigated the proteome of the exhaled breath condensate (EBC) in a porcine model of acute PE in order to identify putative diagnostic markers for PE. EBC was collected at baseline and after the [...] Read more.
Current diagnostic markers for pulmonary embolism (PE) are unspecific. We investigated the proteome of the exhaled breath condensate (EBC) in a porcine model of acute PE in order to identify putative diagnostic markers for PE. EBC was collected at baseline and after the induction of autologous intermediate-risk PE in 14 pigs, plus four negative control pigs. The protein profiles of the EBC were analyzed using label-free quantitative nano liquid chromatography–tandem mass spectrometry. A total of 897 proteins were identified in the EBCs from the pigs. Alterations were found in the levels of 145 different proteins after PE compared with the baseline and negative controls: albumin was among the most upregulated proteins, with 14-fold higher levels 2.5 h after PE (p-value: 0.02). The levels of 49 other proteins were between 1.3- and 17.1-fold higher after PE. The levels of 95 proteins were lower after PE. Neutrophil gelatinase-associated lipocalin (fold change 0.3, p-value < 0.01) was among the most reduced proteins 2.5 h after PE. A prediction model based on penalized regression identified five proteins including albumin and neutrophil gelatinase-associated lipocalin. The model was capable of discriminating baseline samples from EBC samples collected 2.5 h after PE correctly in 22 out of 27 samples. In conclusion, the EBC from pigs with acute PE contained several putative diagnostic markers of PE. Full article
(This article belongs to the Special Issue Pulmonary Embolism in 2021 and Beyond)
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14 pages, 1759 KiB  
Article
Available Bleeding Scoring Systems Poorly Predict Major Bleeding in the Acute Phase of Pulmonary Embolism
by Camille Mathonier, Nicolas Meneveau, Matthieu Besutti, Fiona Ecarnot, Nicolas Falvo, Benoit Guillon, François Schiele and Romain Chopard
J. Clin. Med. 2021, 10(16), 3615; https://doi.org/10.3390/jcm10163615 - 16 Aug 2021
Cited by 4 | Viewed by 2084
Abstract
We aimed to compare six available bleeding scores, in a real-life cohort, for prediction of major bleeding in the early phase of pulmonary embolism (PE). We recorded in-hospital characteristics of 2754 PE patients in a prospective observational multicenter cohort contributing 18,028 person-days follow-up. [...] Read more.
We aimed to compare six available bleeding scores, in a real-life cohort, for prediction of major bleeding in the early phase of pulmonary embolism (PE). We recorded in-hospital characteristics of 2754 PE patients in a prospective observational multicenter cohort contributing 18,028 person-days follow-up. The VTE-BLEED (Venous Thrombo-Embolism Bleed), RIETE (Registro informatizado de la enfermedad tromboembólica en España; Computerized Registry of Patients with Venous Thromboembolism), ORBIT (Outcomes Registry for Better Informed Treatment), HEMORR2HAGES (Hepatic or Renal Disease, Ethanol Abuse, Malignancy, Older Age, Reduced Platelet Count or Function, Re-Bleeding, Hypertension, Anemia, Genetic Factors, Excessive Fall Risk and Stroke), ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation), and HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile International Normalized Ratio, Elderly, Drugs/Alcohol) scores were assessed at baseline. International Society on Thrombosis and Haemostasis (ISTH)-defined bleeding events were independently adjudicated. Accuracy of the overall original 3-level and newly defined optimal 2-level outcome of the scores were evaluated and compared. We observed 82 first early major bleedings (3.0% (95% CI, 2.4–3.7)). The predictive power of bleeding scores was poor (Harrel’s C-index from 0.57 to 0.69). The RIETE score had numerically higher model fit and discrimination capacity but without reaching statistical significance versus the ORBIT, HEMORR2HAGES, and ATRIA scores. The VTE-BLEED and HAS-BLED scores had significantly lower C-index, integrated discrimination improvement, and net reclassification improvement compared to the others. The rate of observed early major bleeding in score-defined low-risk patients was high, between 15% and 34%. Current available scoring systems have insufficient accuracy to predict early major bleeding in patients with acute PE. The development of acute-PE-specific risk scores is needed to optimally target bleeding prevention strategies. Full article
(This article belongs to the Special Issue Pulmonary Embolism in 2021 and Beyond)
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7 pages, 244 KiB  
Article
Correlation between Potential Risk Factors and Pulmonary Embolism in Sarcoidosis Patients Timely Treated
by Barbara Ruaro, Paola Confalonieri, Mario Santagiuliana, Barbara Wade, Elisa Baratella, Metka Kodric, Maria Berria, Mohamad Jaber, Chiara Torregiani, Cosimo Bruni, Marco Confalonieri and Francesco Salton
J. Clin. Med. 2021, 10(11), 2462; https://doi.org/10.3390/jcm10112462 - 2 Jun 2021
Cited by 15 | Viewed by 1978
Abstract
Background. Some studies with inconclusive results have reported a link between sarcoidosis and an increased risk of pulmonary embolism (PE). This study aimed at assessing a possible correlation between potential risk factors and PE in sarcoidosis patients. Methods. A total of 256 sarcoidosis [...] Read more.
Background. Some studies with inconclusive results have reported a link between sarcoidosis and an increased risk of pulmonary embolism (PE). This study aimed at assessing a possible correlation between potential risk factors and PE in sarcoidosis patients. Methods. A total of 256 sarcoidosis patients (84 males and 172 females; mean age at diagnosis 49 ± 13) were enrolled after giving written informed consent. Clinical evaluations, laboratory and radiology tests were performed to evaluate the presence of pulmonary embolism. Results. Fifteen sarcoidosis patients with PE (4 males and 11 females; mean age at diagnosis 50 ± 11), diagnosed by lung scintigraphy and 241 sarcoidosis patients without PE (80 males and 161 females; mean age at diagnosis 47 ± 13), were observed. There was a statistically significant increase of the presence of antiphospholipid antibodies in the sarcoidosis group with pulmonary embolism. There was no statistically significant difference between the two groups as to smoking habit, obesity or hereditary thrombophilia frequency (p > 0.05, respectively). Conclusions. This study demonstrates a significant correlation between the presence of antiphospholipid antibody positivity and the pulmonary embolism events in our sarcoidosis patients. Furthermore, we propose screening for these antibodies and monitoring, aimed at timely treatment. Full article
(This article belongs to the Special Issue Pulmonary Embolism in 2021 and Beyond)
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