Advances in Usual Care of Coronary Artery Disease: Mechanisms and Outcome of Cardiologic, Exercise, and Psychosocial Studies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: closed (25 September 2022) | Viewed by 7817

Special Issue Editor


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Guest Editor
Charity Medical Department, Division of Psychosomatic Medicine, Charity University Berlin, Berlin, Germany
Interests: coronary artery disease; basic care; psychosocial diagnostics; mechanisms; psychosocial interventions

Special Issue Information

Dear Colleagues,

Many intervention studies of coronary artery disease (CAD) have found health benefits for patients in the “treatment as usual” or basic care group. In this series, we invite clinicians and scientists to present and discuss the role and reasons for those effects. In a health care perspective it seems necessary and beneficial to examine effective mechanisms of cardiologic – behavioral interactions on a basic care level. Especially, we invite to focus on the therapeutic alliance between patient and care professional and their efficacy on patients cardiac, behavioral and psychological outcome. In non-selected or psychodiagnostic defined subgroups of CAD (depressive, anxious, non-adherence patients or other) the optimizing of usual care or the efficacy of psychosocial treatment, coronary exercise groups or other interventions with behavioral therapeutic techniques should be demonstrated.

The effectiveness of usual care in cardiologic, exercise and psychosocial outcome studies is impressive and influenced by various factors.  Intense medical attention, additional counselling, and teaching of therapeutic techniques with clinical competence (1) may guide to a satisfactory outcome and strengthen the therapeutic alliance between patient and care giver. These factors may be moderators of efficacy related to a better adherence, to deminish cardiac risk factors and to optimize drug intake.

  1. Regarding the therapeutic quality of usual care, it it possible for the physician to give the symptom a name, or a diagnosis, which is in line with the subjective theory of the patient and convinced him or her, inspired confidence and positive expectation? Do the physician take the patient seriously, do he or she inform the patient about the next diagnostic steps and the procedure of therapy? Do he or she assure him/herselfs that the patient cooperates?
  2. The course of usual care covers interactions generated by the patient himself and by care professionals. A remission of disease or sedentary lifestyle, psychological symptoms could be evoked by increased hope and stronger resistance of an individual. If patients obtained higher medical and social support from their cardiologists, this experience can lead to the reduction in psychological symptoms and risk factors.
  3. In which way the well-known mediators of treatment outcomeg., therapeutic alliance, expressed empathy or dysfunctional thinking, in individual physician-patient contacts, which give support for enhanced cardiological and psychological usual care in CAD patients, are effective and may influence adherence to medication, or progress of coronary disease. It seems necessary to examine and understand several effective cardiologic, hormonal, autonomic and inflammatory therapeutic mechanisms. This knowledge should present as a basic condition for additional behavioural therapeutic activities on a primary care level (1).
  4. In this perspective different patient groups, related to gender, low SES or immigrant status need different interactive activities and communicative skills of the care provider.
  5. What therapeutic dose of usual care is necessary in cardiac patients to stabilize the cardiologic and psychologic individual situation of a patient? In the ENRICHD trial the control participants received usual care, education, and on demand anti-depressant medication, psychotherapy and participated in cardiac rehabilitation. [2].

Selection: Specified psychotherapeutic interventions, coronary exercise groups have shown an additional independent effects on morbidity and mortality. There is a need to identify patients at risk for a sedentary lifestyle of remaining depressed, anxious or under severe stress during usual care (3). These patients may require additional attention and therapeutic actions. These provide in a greater extend of physical activity, reduction of depressive and anxiety symptoms and enable additionally a decrease in cardiovascular events and mortality.

Prof. Hans-Christian Deter
Guest Editor

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Keywords

  • coronary artery disease
  • basic care
  • depression
  • anxiety
  • adherence
  • physical activity
  • exercise
  • mechanisms
  • individual and group interventions

Published Papers (5 papers)

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14 pages, 542 KiB  
Article
Does Anxiety Affect Survival in Patients with Coronary Heart Disease?
by Hans-Christian Deter, Wolfgang Albert, Cora Weber, Melanie Merswolken, Kristina Orth-Gomér, Christoph Herrmann-Lingen and Anna-Sophia Grün
J. Clin. Med. 2023, 12(6), 2098; https://doi.org/10.3390/jcm12062098 - 07 Mar 2023
Viewed by 1795
Abstract
Introduction: Behavioral and physiological risk factors worsen the prognosis of coronary heart disease (CHD). Anxiety is known to be a psychological predictor of CHD. In this study, we investigated whether this factor is associated with all-cause mortality in CHD patients in the long [...] Read more.
Introduction: Behavioral and physiological risk factors worsen the prognosis of coronary heart disease (CHD). Anxiety is known to be a psychological predictor of CHD. In this study, we investigated whether this factor is associated with all-cause mortality in CHD patients in the long term. Methods: We studied 180 patients (mean age 60.6 SD 9.2 years, 26% women) with CHD from the Berlin Anxiety Trial (BAT) and the Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease (SPIRR-CAD) study. Their cardiac and psychological risk profile was represented by standardized procedures, including the Hospital Anxiety and Depression Scale (HADS) questionnaire. Mortality outcomes were assessed using a community-based registry. Results: Of 180 patients, we obtained information on all-cause mortality in 175 (96.7%) after a mean follow-up of 12.2 years (range 10.4–16.6 years). Of all participants, 54.4% had prior myocardial infarction, 95.3% had percutaneous transluminal coronary angioplasty and 22.2% had prior coronary artery bypass graft. Most of the patients (98.4%) had New York Heart Association class I and II, 25.6% had diabetes and 38.2% were smokers. Patients had a mean HADS anxiety score of 9.7 SD 4.1 at study entrance. We found the highest HADS anxiety quartile all-cause mortality in 14%, 30.2% in the middle quartiles and 58.7% in the lowest quartile (chi2 20.8, p = 0.001). Related to psychological mechanisms, a low level of anxiety, seemed to be a significant predictor of all-cause mortality. We found no advantage for patients who had received psychosocial therapy in terms of survival. Conclusion: These first data confirmed our hypothesis about the association of psychological risk factors with the long-term outcome of CAD patients. Future studies will clarify whether the severity of disease, age or a particular type of coping or denial mechanism are associated with the presented outcome in low-anxious patients. Full article
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13 pages, 274 KiB  
Article
Early Trauma-Focused Counseling for the Prevention of Acute Coronary Syndrome-Induced Posttraumatic Stress: Social and Health Care Resources Matter
by Roland von Känel, Rebecca E. Meister-Langraf, Jürgen Barth, Hansjörg Znoj, Jean-Paul Schmid, Ulrich Schnyder and Mary Princip
J. Clin. Med. 2022, 11(7), 1993; https://doi.org/10.3390/jcm11071993 - 02 Apr 2022
Cited by 5 | Viewed by 1558
Abstract
Background: A one-size-fits-all approach might explain why early psychological interventions are largely ineffective in preventing the development of posttraumatic stress disorder (PTSD) symptoms triggered by acute medical events. We examined the hypothesis that social and health care resources are moderators of an intervention [...] Read more.
Background: A one-size-fits-all approach might explain why early psychological interventions are largely ineffective in preventing the development of posttraumatic stress disorder (PTSD) symptoms triggered by acute medical events. We examined the hypothesis that social and health care resources are moderators of an intervention effect. Methods: Within 48 h of hospital admission, 129 patients (mean age 58 years, 83% men) with acute coronary syndrome (ACS) self-rated their social support and were randomized to one single session of trauma-focused counseling (TFC) or stress-focused counseling (SFC) (active control intervention). Clinician-rated PTSD symptoms, use of cardiac rehabilitation (CR) and use of psychotherapy were assessed at 3 and 12 months. Random mixed regression multivariable models were used to analyze associations with PTSD symptoms over time. Results: TFC did not prevent ACS-induced PTSD symptom onset better than SFC; yet, there were significant and independent interactions between “intervention” (TFC or SFC) and social support (p = 0.013) and between “intervention” and duration of CR in weeks (p = 0.034). Patients with greater social support or longer participation in CR had fewer PTSD symptoms in the TFC group compared with the SFC group. The number of psychotherapy sessions did not moderate the intervention effect. Conclusions: Early psychological intervention after ACS with a trauma-focused approach to prevent the development of PTSD symptoms may be beneficial for patients who perceive high social support or participate in CR for several weeks. Full article
15 pages, 314 KiB  
Article
Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study
by Monika Sadlonova, Jochen Senges, Jonas Nagel, Christopher Celano, Caroline Klasen-Max, Martin Borggrefe, Ibrahim Akin, Dierk Thomas, Christopher Jan Schwarzbach, Thomas Kleeman, Steffen Schneider, Matthias Hochadel, Tim Süselbeck, Harald Schwacke, Angelika Alonso, Markus Haass, Karl-Heinz Ladwig and Christoph Herrmann-Lingen
J. Clin. Med. 2022, 11(4), 1140; https://doi.org/10.3390/jcm11041140 - 21 Feb 2022
Cited by 8 | Viewed by 2126
Abstract
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL in AF. Methods: [...] Read more.
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL in AF. Methods: Using data from the observational Atrial Fibrillation Rhine-Neckar Region (ARENA) trial, we identified medical and psychosocial factors associated with AF-related symptom severity using European Heart Rhythm Association symptom classification and HRQoL using 5-level EuroQoL- 5D. Results: In 1218 AF patients (mean age 71.1 ± 10.5 years, 34.5% female), female sex (OR 3.7, p < 0.001), preexisting coronary artery disease (CAD) (OR 1.7, p = 0.020), a history of cardioversion (OR 1.4, p = 0.041), cardiac anxiety (OR 1.2; p < 0.001), stress from noise (OR 1.4, p = 0.005), work-related stress (OR 1.3, p = 0.026), and sleep disturbance (OR 1.2, p = 0.016) were associated with higher AF-related symptom severity. CAD (β = −0.23, p = 0.001), diabetes mellitus (β = −0.25, p < 0.001), generalized anxiety (β = −0.30, p < 0.001), cardiac anxiety (β = −0.16, p < 0.001), financial stress (β = −0.11, p < 0.001), and sleep disturbance (β = 0.11, p < 0.001) were associated with impaired HRQoL. Conclusions: Psychological characteristics, preexisting CAD, and diabetes may play an important role in the identification of individuals at highest risk for impaired HRQoL and high symptom severity in patients with AF. Full article

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2 pages, 181 KiB  
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Reply to Sopek Merkaš, I.; Lakušić, N. Comment on “von Känel et al. Early Trauma-Focused Counseling for the Prevention of Acute Coronary Syndrome-Induced Posttraumatic Stress: Social and Health Care Resources Matter. J. Clin. Med. 2022, 11, 1993”
by Rebecca E. Meister-Langraf, Mary Princip, Jürgen Barth, Ulrich Schnyder, Hansjörg Znoj, Jean-Paul Schmid and Roland von Känel
J. Clin. Med. 2022, 11(22), 6633; https://doi.org/10.3390/jcm11226633 - 09 Nov 2022
Cited by 1 | Viewed by 683
Abstract
We thank Merkaš and Lakušić for commenting on our recently published paper; in the paper, we suggested that resources in a patient’s social environment may moderate the benefit of one single-session trauma-focused counseling in the prevention of acute coronary syndrome (ACS)-induced posttraumatic stress [...] Read more.
We thank Merkaš and Lakušić for commenting on our recently published paper; in the paper, we suggested that resources in a patient’s social environment may moderate the benefit of one single-session trauma-focused counseling in the prevention of acute coronary syndrome (ACS)-induced posttraumatic stress disorder (PTSD) symptoms [...] Full article
2 pages, 174 KiB  
Comment
Comment on von Känel et al. Early Trauma-Focused Counseling for the Prevention of Acute Coronary Syndrome-Induced Posttraumatic Stress: Social and Health Care Resources Matter. J. Clin. Med. 2022, 11, 1993
by Ivana Sopek Merkaš and Nenad Lakušić
J. Clin. Med. 2022, 11(20), 6036; https://doi.org/10.3390/jcm11206036 - 13 Oct 2022
Cited by 1 | Viewed by 1155
Abstract
Posttraumatic stress disorder (PTSD) is a debilitating disorder, and it is known that it can be triggered by acute coronary syndrome (ACS). Patients with ACS-induced PTSD have an increased risk of recurrent adverse cardiovascular events and mortality. This is still an insufficiently recognized [...] Read more.
Posttraumatic stress disorder (PTSD) is a debilitating disorder, and it is known that it can be triggered by acute coronary syndrome (ACS). Patients with ACS-induced PTSD have an increased risk of recurrent adverse cardiovascular events and mortality. This is still an insufficiently recognized subgroup of patients among clinicians that could benefit from specific therapeutic and rehabilitation approaches. Full article
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