Special Issue "New Tools for Predicting Preterm Birth in Asymptomatic High-Risk Women"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 15 September 2021.

Special Issue Editor

Dr. Liran Hiersch
Guest Editor
Department Obstetrics Gynecology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Interests: obstetric delivery; prenatal diagnosis; fetal growth restriction; doppler; ultrasonography; obstetrics; fetal medicine; preeclampsia; fetal growth retardation; fetal diseases; prenatal ultrasonography; prenatal care;

Special Issue Information

Dear Colleagues,

Preterm birth (PTB) remains one of the biggest challenges in contemporary obstetrics, as it is associated with an increased risk of mortality as well as short- and long-term morbidity of the offspring. Many risk factors for PTB were identified, including multiple gestation, history of PTB, cervical pathology, and uterine factors, among others. As a result, many women are currently classified as being at high risk for PTB, although many of them are asymptomatic prior to delivery. Although extensive research was conducted in this field, the ability of the various available tools to accurately predict PTB remains insufficient. Accurate prediction of PTB is crucial, as it can assist in selecting optimal prevention measurements and counseling regarding the suitable antepartum follow up and the need for potential transfer to the appropriate facility in cases of very high risk of PTB. In contrast, in those found to be at a lower risk, reassurance may relive emotional stress and prevent unnecessary impairment of the daily routine. The present Special Issue aims to deepen the specificity of new tools designed for the prediction of PTB among high-risk women who are asymptomatic. Hopefully, new evidence will increase the knowledge of clinicians and researchers, facilitate collaborations, and improve maternal and neonatal health.

Dr. Liran Hiersch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • preterm birth
  • high-risk pregnancy
  • prediction
  • prematurity
  • tools

Published Papers (1 paper)

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Open AccessArticle
The Risk of Preterm Birth in Women with Three Consecutive Deliveries—The Effect of Number and Type of Prior Preterm Births
J. Clin. Med. 2020, 9(12), 3933; https://doi.org/10.3390/jcm9123933 - 04 Dec 2020
Background: We aimed to explore the association of the number, order, gestational age and type of prior PTB and the risk of preterm birth (PTB) in the third delivery in women who had three consecutive singleton deliveries. Methods: A retrospective cohort study of [...] Read more.
Background: We aimed to explore the association of the number, order, gestational age and type of prior PTB and the risk of preterm birth (PTB) in the third delivery in women who had three consecutive singleton deliveries. Methods: A retrospective cohort study of all women who had three consecutive singleton births at a single medical center over a 20-year period (1994–2013). The primary outcome was PTB (<37 weeks) in the third delivery. Results: 4472 women met inclusion criteria. The rate of PTB in the third delivery was 4.9%. In the adjusted analysis, the risk of PTB was 3.5% in women with no prior PTBs; 10.9% in women with prior one PTB only in the first pregnancy; 16.2% in women with prior one PTB only in the second pregnancy; and 56.5% in women with prior two PTBs. A similar trend was observed when the outcome of interest was spontaneous PTB and when the exposure was limited to prior spontaneous or indicated PTB. Conclusions: In women with a history of PTB, the risk of recurrent PTB in subsequent pregnancies is related to the number and order of prior PTBs. These factors should be taken into account when stratifying the risk of PTB. Full article
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