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Cutting-Edge Advances in Assisted Reproductive Technologies (ART) and In Vitro Fertilization (IVF)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 1068

Special Issue Editor


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Guest Editor
1. Sperm Bank & Andrology Unit, Shamir Medical Center, Zrifin 70300, Israel
2. IVF Department, Shamir Medical Center, Zrifin 70300, Israel
3. Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Interests: andrology; gamete donation; controlled ovarian hyperstimulation; high responders; fertility preservation

Special Issue Information

Dear Colleagues,

Reproduction has been and probably will forever remain a fundamental cornerstone of human life. The introduction of In Vitro Fertilization (IVF) over four decades ago cannot be seen as a medical revolution alone. Its impact expanded global social trends and challenged conventional perceptions. Over 10 million live births are only the first evidence of its efficacy. Moreover, adaptations of family types, the prevention of monogenic diseases, fertility preservation, and other breakthroughs that changed medical reality demonstrate the crucial and global impact of assisted reproductive technologies (ARTs) on human lives. The common principle that enables these dramatic developments is scientific excellence led by enthusiastic clinicians and researchers. Intracytoplasmic sperm injection (ICSI), testicular biopsies, improved stimulation protocols, enhanced embryo incubation devised and protocols, egg freezing, and many other achievements made ART safer and more efficient than ever.

Novel inventions are accompanied by new dilemmas. Artificial intelligence (AI) seems like the next revolution. We are only beginning to understand its potential advantages in clinical and laboratory settings. However, scientific, medical, and ethical limitations and controls over the use of AI are required to ensure the safety of this powerful tool. Genetic and epigenetic influences on human health represent additional challenges as the cost of sequencing bioinformatics becomes more affordable than ever. While improved diagnosis capabilities provide new opportunities, they also present a physical task that will evolve and progress over time. In addition to these global advances, specific clinical scenarios still necessitate improved medical solutions. Recurrent implantation failure, fertility preservation among prepubertal boys, and other unsolved clinical scenarios require further research and novel ideas. Indeed, past achievements should encourage and inspire us to launch future discoveries.

Dr. Itai Gat
Guest Editor

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Keywords

  • assisted reproductive technologies (ART)
  • in vitro fertilization (IVF)
  • artificial intelligence
  • genetics and epigenetics
  • fertility preservation
  • male factor

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Published Papers (1 paper)

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Research

17 pages, 1331 KiB  
Article
Morphometric Blastocyst Assessment: A Retrospective Study Examining the Relationship Between Blastocyst Diameter and Area and Pregnancy Outcomes in Assisted Reproduction Technology Cycles
by Romualdo Sciorio, Pier Francesco Greco, Luca Tramontano, Giuseppe Gullo and Ermanno Greco
J. Clin. Med. 2025, 14(8), 2827; https://doi.org/10.3390/jcm14082827 - 19 Apr 2025
Viewed by 766
Abstract
Objective: In assisted reproductive technology (ART), achieving a successful pregnancy requires optimizing an embryo culture and selecting the single embryo with the highest implantation potential, capable of resulting in a healthy pregnancy. The primary goal of this study was to determine the [...] Read more.
Objective: In assisted reproductive technology (ART), achieving a successful pregnancy requires optimizing an embryo culture and selecting the single embryo with the highest implantation potential, capable of resulting in a healthy pregnancy. The primary goal of this study was to determine the correlation between the blastocyst area and diameter and pregnancy outcomes in ART treatments. Methods: In this study, the blastocyst diameter and area were measured to determine whether these morphometric features could predict pregnancy outcomes in couples undergoing ART with ICSI. This is a retrospective trial analyzing 665 patients who underwent an ART cycle with the transfer of a single blastocyst on day 5. Results: Both morphometric features assessed were significantly associated with implantation and ongoing pregnancy outcomes. Our results showed that the implantation rate (IR) and ongoing clinical pregnancy rate (CPR) were significantly higher with a blastocyst area ≥ 25,000 µm2 compared to <25,000 µm2 (IR: 69.8% versus 47.9%, p < 0.001; CPR: 65.5% versus 45.9% p < 0.001). Additionally, a blastocyst diameter ≥ 170 µm resulted in a significantly higher IR and CPR compared to embryos with a diameter < 170 µm (IR: 68.8% versus 36.6%, p < 0.001; CPR: 66.3 versus 35.7%, p < 0.001). Conclusions: Blastocyst morphometric variables, being objective and measurable, are not subject to intra-operator variability and may serve as promising predictors of embryo viability and ongoing pregnancy success. These morphometric assessments could assist embryologists in selecting the embryo with the highest implantation potential from a cohort, as well as identifying those with a reduced chance of generating a successful pregnancy. Full article
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