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Osteomyelitis: Diagnosis, Management and Future Opportunities
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Osteomyelitis: Diagnosis, Management and Future Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 3788

Special Issue Editor

Dr. Peter G. Passias

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Guest Editor
Division of Spinal Surgery, Department of Neurological and Orthopaedic Surgery, NYU Langone Medical Center, NYU School of Medicine 550 1st Ave., New York, NY 10016, USA
Interests: orthopaedic surgery; lordosis; kyphosis; spinal cord diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to present this Special Issue of the Journal of Clinical Medicine on “Osteomyelitis: Diagnosis, Management, and Future Opportunities.” The purpose of this issue is to investigate the clinical management of osteomyelitis, an infection of the structural components of the musculoskeletal system that can present in adults or children, especially those with particular risk factors. The nonspecific presenting symptoms such as localized pain, swelling, and fever bespeak the intricacy of the diagnosis and necessitate correlation with advanced diagnostic imaging. Management depends on the extent and characterization of the infection, with long-term broad spectrum antibiotics being an essential component in the mainstay of treatment options. Surgical intervention may be required to debride dead bone and surrounding tissue to prevent further spread or reinoculation. The increasing knowledge about the pathophysiology and treatment outcomes will further allow us to risk stratify those with osteomyelitis and properly regulate their condition.

Dr. Peter G. Passias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteomyelitis
  • inflammation
  • antibiotics
  • staphylococcus aureus
  • septic
  • surgical debridement
  • infection
  • reconstructive fusion
  • corpectomy

Published Papers (2 papers)

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Research

9 pages, 242 KiB  
Article
Assessing the Effects of Prior History of Vertebral Osteomyelitis on Peri-Operative Factors and Post-Operative Recovery in Adult Spinal Deformity Patients
by Peter S. Tretiakov, Rachel Joujon-Roche, Tyler Williamson, Bailey Imbo, Claudia Bennett-Caso, Pooja Dave, Kimberly McFarland, Jamshaid Mir, Michael Dinizo, Andrew J. Schoenfeld and Peter G. Passias
J. Clin. Med. 2022, 11(21), 6488; https://doi.org/10.3390/jcm11216488 - 01 Nov 2022
Cited by 1 | Viewed by 1196
Abstract
Vertebral osteomyelitis (VOM), which includes the clinical entities of spinal osteomyelitis, spondylodiscitis, or pyogenic spondylitis, describes a complex inflammatory reaction within the vertebral column in the setting of microbial infection [...] Full article
(This article belongs to the Special Issue Osteomyelitis: Diagnosis, Management and Future Opportunities)
10 pages, 642 KiB  
Article
Risk Factors for Postoperative Osteomyelitis among Patients after Bone Fracture: A Matched Case–Control Study
by Gulnur Slyamova, Arnur Gusmanov, Arman Batpenov, Nurlan Kaliev and Dmitriy Viderman
J. Clin. Med. 2022, 11(20), 6072; https://doi.org/10.3390/jcm11206072 - 14 Oct 2022
Cited by 5 | Viewed by 2175
Abstract
The healthcare burden of osteomyelitis is increasing. Postoperative and posttraumatic osteomyelitis account for 80% of all cases of osteomyelitis. The aim of this study was to find risk factors for postoperative osteomyelitis in Kazakhstan. We included 245 patients admitted to the National Scientific [...] Read more.
The healthcare burden of osteomyelitis is increasing. Postoperative and posttraumatic osteomyelitis account for 80% of all cases of osteomyelitis. The aim of this study was to find risk factors for postoperative osteomyelitis in Kazakhstan. We included 245 patients admitted to the National Scientific Center of Traumatology and Orthopedics from 2018 to 2020. Cases were matched with controls in a 1:4 ratio. Exact matching was performed by gender, ICD-10, and ICD-9 codes. The main variables included socio-demographics, diagnosis at admission, characteristics of fractures, comorbidities, complications, hospitalization milestones, and osteomyelitis characteristics. Descriptive analyses, along with bivariate analysis and multivariate conditional logistic regression, were performed. Open fracture (adjOR = 6.25; 95%CI 1.64–23.79), the presence of complications of initial fracture (adjOR = 3.46, 95%CI 1.13–10.56), comminuted fracture form (adjOR = 1.87; 95%CI 0.73–4.75), a positive history of diabetes or blood glucose >7 g/L (adjOR = 4.25; 95%CI 1.26–14.3), incision or wound length of more than 10 cm (adjOR = 6.53; 95%CI 1.1–38.6), additional implanted medical item (adjOR = 1.23; 95% CI 1.1–1.47), and unemployment or being retired (adjOR = 4.21; 95%CI 1.74–10.18) were found to be significant predictors of postoperative osteomyelitis. Almost all our findings are concordant with previous studies, except for the type of fracture. Different authors report conflicting results on the latter potential risk factor. Therefore, prospective studies on this issue are required. Full article
(This article belongs to the Special Issue Osteomyelitis: Diagnosis, Management and Future Opportunities)
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