Advances in the Colorectal Cancer
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".
Deadline for manuscript submissions: closed (25 December 2024) | Viewed by 973
Special Issue Editor
Special Issue Information
Dear Colleagues,
Colorectal cancer is the second leading cause of death from cancer in the United States. In 2023, 1,535,020 new cases of colorectal cancer have been diagnosed with over 52,550 deaths. Although the overall mortality is declining, the mortality has increased from 0.5 to 3% annually in the younger age group (under 55 years of age). There has been an increase in left-sided versus right-sided tumors. The use of immunotherapy regimens for mismatch repair-deficient colorectal cancer and use of targeted therapy, like the combination of trastuzumab and tucatinb for HER2-positive colorectal cancer, has definitely made an impact on outcomes for patients with metastatic colorectal cancer. The use of genomic testing upfront to guide treatment decisions has been key in improving progression-free survival and overall survival for patients with colorectal cancer. In patients with colorectal cancer that have liver-only metastases, the varied liver-directed treatment options, like transarterial chemoembolization, transarterial radioembolization, radiofrequency ablation, liver transplant and use of hepatic artery infusion pump therapy, have accelerated the progress in the metastatic colorectal arena.
In this Special Issue, you are invited as an expert in the field to share your insight and submit a manuscript on the novel research and treatment strategies that have advanced the survival of patients with colorectal cancer.
Dr. Olivia Aranha
Guest Editor
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Keywords
- colorectal cancer
- progress
- treatment
- liver-directed therapy
- radiation
- immunotherapy
- mismatch repair deficient
- microsatellite instability
- genomics
- peritoneal carcinomatosis
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