New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases: 2nd Edition
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 31
Special Issue Editor
Interests: therapeutic drug monitoring; anti-TNF therapy; biologics; inflammatory bowel disease; immunogenicity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biological therapy is the cornerstone treatment for inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). However, some patients either do not respond at all to biologics or may lose response over time. These unfavorable outcomes can be mostly explained by inadequate drug exposure with or without the development of antidrug antibodies, which refers more to the anti-tumor necrosis factor (anti-TNF) therapy. Cumulative data suggest that proactive TDM of anti-TNFs, aiming for a predefined therapeutic drug concentration, is associated with improved clinical outcomes. Preliminary information suggests that proactive TDM may also be efficacious in other anti-TNF biologics such as vedolizumab and ustekinumab, although data are scarce. Recent advances regarding TDM include the use of point-of-care assays and model-informed precision dosing towards a personalized application of TDM. Knowledge gaps regarding the role of TDM in clinical practice include the determination of the optimal drug concentrations to target and the role of peak drug concentrations, stool or tissue drug concentrations, and total drug exposure. Future perspectives regarding the role of TDM include the use of pharmacogenetics towards individual personalized medicine. The aim of this Special Issue is to highlight recent advances and future perspectives in the use of TDM in IBD and other IMIDs.
Dr. Konstantinos Papamichael
Guest Editor
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Keywords
- therapeutic drug monitoring
- inflammatory bowel diseases
- immune mediated inflammatory diseases
- pharmacokinetics
- anti-TNF
- vedolizumab
- ustekinumab
- risankizumab
- point-of-care assays
- model informed precision dosing
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