Pathogenesis, Diagnosis and Therapies of Gout and Hyperuricemia
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: closed (10 August 2021) | Viewed by 532
Special Issue Editors
Interests: general rheumatology; spondyloarthritis
Special Issue Information
Dear colleagues,
Research in hyperuricemia and gout has made tremendous progress since the turn of the century. Essentially all facets of this, the most common inflammatory rheumatic disease, have been reworked. The inflammasome discovery clarified the long unexplained clinical behavior of gout, while the whole genome assessments for urate-associated loci and the first studies on the epigenetics of gout and hyperuricemia expanded our knowledge of the pathogenesis. We started better appreciating the role and prognostic significance of hyperuricemia within the family of metabolic disorders. Our diagnostic arsenal for clinical gout has incredibly expanded as well, with musculoskeletal ultrasound becoming the leading bed-side diagnostic tool and dual-energy computed tomography being able to demonstrate and quantify deposits of the uric acid in previously inaccessible locations. Finally, extensive research on the different aspects of hyperuricemia and gout treatment, including both dietary recommendations and usage of newer medicines, such as febuxostat or uricase, has recently been published. The appearance of such an extensive bulk of new data in the field of gout has recently triggered the announcement of new guidelines on its management. This Special Issue aims to highlight the broad spectrum of recent advances in the field of gout and hyperuricemia.
Prof. Dr. Gleb Slobodin
Dr. Lisa Kaly
Guest Editors
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Keywords
- Gout
- Hyperuricemia
- Epigenetics
- Inflammasome
- Musculoskeletal ultrasound
- Dual energy computed tomography
- Diet
- Treat-to-target
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