Evolving Therapies in Metastatic Prostate Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1094

Special Issue Editors


E-Mail Website
Guest Editor
Department of Urology, Yale School of Medicine, 800 Howard Ave Fl 3, New Haven, CT 06519, USA
Interests: urologic cancers; prostate cancer; laparoscopic; surgeries

E-Mail Website
Guest Editor
Department of Urology, Yale School of Medicine, 800 Howard Ave Fl 3, New Haven, CT 06519, USA
Interests: urologic cancers; bladder cancer; prostate cancer; urologic surgery

Special Issue Information

Dear Colleagues,

Welcome to this Special Issue of "Evolving Therapies in Metastatic Prostate Cancer". Prostate cancer remains the most commonly diagnosed malignancy in men in the United States and worldwide. With the advancements in localized therapy, men are enjoying extended survival with prostate cancer; however, many men will develop recurrence and progression to metastatic disease. The advancements in medical therapies available for metastatic disease over the last 15 years have nearly doubled the time men can survive with metastatic disease. Challenges with the appropriate sequencing of the multitude of new medications available for metastatic prostate cancer are now faced by clinicians. We hope that you gain additional knowledge regarding the prostate cancer treatment landscape currently available for patients with metastatic prostate cancer.

Dr. Joseph Renzulli
Dr. Soum D. Lokeshwar
Guest Editors

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Keywords

  • prostate cancer
  • metastatic prostate cancer
  • metastatic disease
  • therapies
  • men’s health

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Published Papers (1 paper)

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Review

16 pages, 624 KiB  
Review
Advances in Current Treatment Paradigms for Metastatic Hormone-Sensitive Prostate Cancer
by Shayan Smani, Julien DuBois, Ismail Ajjawi, Nishan Sohoni, Ankur U. Choksi, Soum D. Lokeshwar, Isaac Y. Kim and Joseph F. Renzulli II
J. Clin. Med. 2025, 14(8), 2565; https://doi.org/10.3390/jcm14082565 - 8 Apr 2025
Viewed by 876
Abstract
Metastatic hormone-sensitive prostate cancer (mHSPCa) presents de novo or represents significant disease progression and requires systemic treatment. However, progression to castration resistance is inevitable. The treatment landscape has evolved with the introduction of intensified systemic therapy, including androgen deprivation therapy (ADT) combined with [...] Read more.
Metastatic hormone-sensitive prostate cancer (mHSPCa) presents de novo or represents significant disease progression and requires systemic treatment. However, progression to castration resistance is inevitable. The treatment landscape has evolved with the introduction of intensified systemic therapy, including androgen deprivation therapy (ADT) combined with either androgen receptor signaling inhibitors (ARSIs) or cytotoxic chemotherapy (doublet therapy) or combined therapy with both agents (triplet therapy). Landmark trials such as CHAARTED, STAMPEDE, LATITUDE, ENZAMET, and TITAN have established combination therapies as the standard of care, demonstrating significant overall survival benefits. More recently, triplet therapy—integrating ADT, docetaxel, and an ARSI—has emerged as an effective approach, particularly in high-volume metastatic disease, as supported by ARASENS and PEACE-1. Advances in imaging, such as PSMA PET-CT, have improved disease detection, allowing earlier detection of metastasis and appropriate therapy. Similarly, genomic profiling has enabled biomarker-driven, personalized treatment strategies. The role of treatment of the primary tumor, by either radiation therapy or cytoreductive prostatectomy, in low-volume disease continues to be explored. As novel therapies, targeted agents, and immunotherapies undergo investigation, optimizing treatment selection based on disease burden, molecular characteristics, and patient factors will be essential. The future of mHSPCa management lies in multidisciplinary, precision-based approaches to improve patient outcomes while balancing treatment efficacy and tolerability. Full article
(This article belongs to the Special Issue Evolving Therapies in Metastatic Prostate Cancer)
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