Faecal Microbiota Transplantation in Clinical Practice
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 3757
Special Issue Editors
Interests: microbiome; metaomics techniques; fecal microbiota transplantation; inflammatory bowel disease; irritable bowel syndrome; liver diseases
Special Issue Information
Dear Colleagues,
Fecal microbiota transplantation (FMT) has the potential to restore a perturbed gut microbial ecosystem, as it has been demonstrated by the efficient treatment of Clostridioides difficile infections (CDI). However, the efficiency of FMT is low for other intestinal or extra-intestinal diseases of very high incidence, as it is a case of inflammatory bowel disorders (IBD). This inefficacy could be explained, in part, by the multifactorial nature of IBD, which can develop with a genetic predisposition towards pro-inflammatory immune responses and intestinal barrier dysfunction. Therefore, we need a better understanding of the mechanisms underlying the crosstalk between recipient and donor microbiota. Moreover, a more comprehensive donor screening is also needed to prevent the transmission of microorganisms such as the extended spectrum beta-lactamase (ESBL)-producing E. coli and the SARS-Cov-2 that could lead to adverse infectious events. It is therefore crucial to establish consensus in terms of the route of administration, pre-treatment of recipients, or selection and testing of donor stool among other considerations.
In this Special Issue, "Fecal Microbiota Transplantation in Clinical Practice ", submission of original papers or review articles are welcomed.
Dr. Chaysavanh Manichanh
Dr. Severine Vermeire
Guest Editors
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Keywords
- Intestinal and extra-intestinal disorders
- Randomized controlled trials
- Donor sample screening and testing
- Recipient stratification
- Recipient pre-treatment
- Preparation of fecal material
- Route of administration
- Long-term monitoring of patients
- Feces biobanking
- Requirements for implementing an FMT center
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