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Clinical Advances in Orthopedic Infections
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Clinical Advances in Orthopedic Infections

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 2556

Special Issue Editor

Dr. Hyonmin Choe

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Japan
Interests: orthopedic surgery; robot surgery; orthopedic infections; periprosthetic joint infection; surgical site infection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The complexity of orthopedic infections and their profound impact on patient outcomes has been widely recognized over recent decades. We are honored to present this Special Issue, which provides a platform for sharing the knowledge, experiences, and latest advancements from leading experts in the field of orthopedic infections.

Orthopedic infections significantly impair the quality of life of patients and introduce complex challenges in therapy. Thanks to recent research and technological progress, there have been notable advancements in the prevention, diagnosis, and treatment of these infections. This Special Issue explores such advancements, addressing the current challenges and envisioning future possibilities in the management of orthopedic infections. By connecting clinical insights with scientific breakthroughs, our objective is to illuminate the path forward in the management of orthopedic infections.

We anticipate that this Special Issue will act as a pivotal force in enriching our understanding of orthopedic infections and fostering discussions aimed at establishing best practices in patient care.

Dr. Hyonmin Choe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • orthopedic surgery
  • orthopedic infections
  • periprosthetic joint infection
  • surgical site infection
  • infection management

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Published Papers (2 papers)

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12 pages, 2139 KiB  
Article
Biofilm Growth on Different Materials Used in Contemporary Femoral Head Prosthesis: An In Vitro Study
by Yonggyun Moon, Jaeyoung Hong, Sookyung Choi, Hyoungtae Kim, Hong Moon Sohn and Suenghwan Jo
J. Clin. Med. 2025, 14(5), 1722; https://doi.org/10.3390/jcm14051722 - 4 Mar 2025
Viewed by 858
Abstract
Background/Objectives: Periprosthetic joint infection (PJI) primarily results from bacterial biofilms adhering to prosthetic surfaces, making treatment challenging without prosthesis removal. This in vitro study aims to investigate whether the materials used in contemporary femoral head prosthesis influences bacterial biofilm development. Methods: Femoral [...] Read more.
Background/Objectives: Periprosthetic joint infection (PJI) primarily results from bacterial biofilms adhering to prosthetic surfaces, making treatment challenging without prosthesis removal. This in vitro study aims to investigate whether the materials used in contemporary femoral head prosthesis influences bacterial biofilm development. Methods: Femoral head prostheses made of three different materials—cobalt–chrome, oxinium, and ceramic—were inoculated with either Staphylococcus aureus or Pseudomonas aeruginosa in separate experiments, with each pathogen tested independently. The samples were cultured under shaking conditions at 37 °C for 96 h to promote biofilm formation. Scanning electron microscopy (SEM) was used to confirm the presence of biofilms, and adherent biofilms were quantified by counting colony-forming units (CFUs) after sonication. Additionally, crystal violet staining was performed to assess biofilm distribution on the femoral head surfaces. Statistical analyses compared CFU counts across the different materials. Results: The mean CFU counts for S. aureus were 7.6 × 105 ± 9.7 × 104 for cobalt–chrome, 6.9 × 105 ± 3.6 × 105 for oxinium, and 1.1 × 106 ± 3.0 × 105 for ceramic femoral head prostheses. For P. aeruginosa, the CFU counts were 2.3 × 106 ± 7.2 × 105, 3.7 × 106 ± 2.5 × 106, and 2.2 × 106 ± 8.9 × 105, respectively. Regardless of the bacterial strain, differences among the three materials were within one log range, and no statistical significance was observed. While biofilms were confirmed using SEM, limited adherence was observed on the bearing surface, with the biofilm predominantly localized in the taper hole. Conclusions: The findings suggest that the material used in contemporary femoral head prostheses has minimal impact on bacterial biofilm formation. Surgeons’ choice of femoral head prosthesis material should base their material selection on factors other than PJI prevention. Full article
(This article belongs to the Special Issue Clinical Advances in Orthopedic Infections)
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10 pages, 785 KiB  
Case Report
Neisseria sicca Vertebral Osteomyelitis: A Case Report and Literature Review
by Natasha Priya Dyal, Robert Orenstein and Sandhya Rani Nagarakanti
J. Clin. Med. 2024, 13(23), 7241; https://doi.org/10.3390/jcm13237241 - 28 Nov 2024
Viewed by 1164
Abstract
Background: Culture-negative vertebral osteomyelitis presents a significant diagnostic challenge. Neisseria sicca (N. sicca) is a typically benign commensal organism of the upper respiratory tract that rarely causes invasive infections, warranting cautious interpretation if isolated in a single positive culture. This [...] Read more.
Background: Culture-negative vertebral osteomyelitis presents a significant diagnostic challenge. Neisseria sicca (N. sicca) is a typically benign commensal organism of the upper respiratory tract that rarely causes invasive infections, warranting cautious interpretation if isolated in a single positive culture. This case study details a 62-year-old male diagnosed with vertebral osteomyelitis caused by N. sicca, examining diagnostic challenges, treatment, and outcomes. Methods: We conducted a comprehensive search on MEDLINE using the keywords “Neisseria sicca”, “osteomyelitis”, and “diskitis”. An additional search excluding N. gonorrhea and N. meningitidis was also performed, revealing a total of four cases of N. sicca osteomyelitis in the literature. Results: A 62-year-old male with a history of hypertension, type 2 diabetes, atrial fibrillation, and previous L5-S1 spinal fusion presented with fever and back pain in May 2023. Initial imaging revealed T8-T9 vertebral osteomyelitis. Despite a six-week course of IV daptomycin, his symptoms worsened, prompting further evaluation. A CT-guided biopsy with comprehensive testing, including histopathology and microbial cultures, initially identified N. sicca. Due to its rarity, additional biopsies were conducted, confirming the infection. IV ceftriaxone was initiated, leading to significant pain improvement, and a subsequent MRI showed near resolution. The patient transitioned to oral cefuroxime, with follow-up confirming complete infection resolution by December 2023. Conclusions: This case underscores the importance of a structured diagnostic approach in culture-negative vertebral osteomyelitis to differentiate between commensal contamination and true infection. Repeated positive cultures of N. sicca from a sterile site confirmed its role as the causative agent. Early identification and targeted antibiotic therapy are critical to improving outcomes in rare cases of N. sicca vertebral osteomyelitis. Full article
(This article belongs to the Special Issue Clinical Advances in Orthopedic Infections)
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