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JCM
Special Issues
Neuro-Oncology: Diagnosis and Treatment
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Neuro-Oncology: Diagnosis and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 28 May 2025 | Viewed by 2160

Special Issue Editor

Dr. Shunsuke Shibao

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Guest Editor
1. Department of Neurosurgery, Dokkyo Medical University, Tochigi, Japan 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi 321-0293, Japan
2. Department of Neurosurgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan
Interests: skull base; endoscopy; minimally invasive surgery; endoscopic endonasal surgery; neuro-oncology

Special Issue Information

Dear Colleagues,

We are delighted to announce this Special Issue of JCM, titled "Neuro-Oncology: Diagnosis and Treatment". This Special Issue aims to delve into the latest advancements in brain tumor diagnosis and treatment, covering topics such as genetic- and biomarker-based diagnostics, AI-based image diagnosis, preoperative simulation, AR and VR in surgery, endoscopic and minimally invasive techniques, and skull base surgery breakthroughs. Additionally, it addresses novel therapies for brain tumors. Our goal is to provide valuable insights and updates to medical professionals dedicated to improving patient outcomes in this complex field.

Dr. Shunsuke Shibao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuro-oncology
  • genetic diagnostics
  • biomarker-based diagnostics
  • AI-based image diagnosis
  • preoperative simulation
  • augmented reality (AR)
  • virtual reality (VR)
  • endoscopic surgery
  • minimally invasive surgery
  • skull base surgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

10 pages, 235 KiB  
Article
Deficits of Attention and Working Memory in Patients with Gliomas of Supplementary Motor Area
by Aleksandra Bala, Agnieszka Olejnik, Antonina Gottman-Narożna, Weronika Rejner, Kacper Koczyk, Tomasz Dziedzic and Przemysław Kunert
J. Clin. Med. 2025, 14(4), 1229; https://doi.org/10.3390/jcm14041229 - 13 Feb 2025
Viewed by 893
Abstract
Objectives: The effects of brain tumors located in the supplementary motor area (SMA) have so far been described mainly in the context of motor and speech disorders. There are few studies that have considered other cognitive domains, so this study aimed to fill [...] Read more.
Objectives: The effects of brain tumors located in the supplementary motor area (SMA) have so far been described mainly in the context of motor and speech disorders. There are few studies that have considered other cognitive domains, so this study aimed to fill this gap by focusing on examining attention and working memory in a population of patients with gliomas in the SMA region. Methods: This study included 50 patients diagnosed with gliomas located in the SMA who have not yet had any treatment and 57 demographically matched healthy individuals. A set of neuropsychological tests was conducted to assess attention and working memory: Digit Span from WAIS-R, Visual Elevator from TEA, Verbal Fluency Test (switching condition), and Color Trails Test (CTT). Results: The analyses showed that patients scored lower in most of the evaluated tests and indicators, namely in Digit Span-forward (t = −2.05; p = 0.022), Digit Span-backward (t = −2.63; p = 0.005), CTT-2 (t = 4.24; p = 0.001), CTT-interference (t = 2.31; p = 0.012), Visual Elevator-time (t = 1.83; p = 0.035), Visual Elevator-accuracy (t = −2.42, p = 0.010), and Verbal Fluency-switching (t = −3.41; p = 0.001). A significant relationship was also demonstrated between the grade of tumor malignancy and the results achieved in some of the neuropsychological tests. The lateralization of the tumor, the size of the lesion, and the presence of epilepsy did not prove to be particularly significant. Conclusions: Due to the significant decline in cognitive performance in terms of attention and working memory, we believe that every patient with a tumor in the SMA should undergo a detailed neuropsychological examination, which will profile their functioning and help tailor the best possible psychological care. Full article
(This article belongs to the Special Issue Neuro-Oncology: Diagnosis and Treatment)
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13 pages, 1823 KiB  
Article
Postoperative Vision-Related Quality of Life After Sphenoid Wing Meningioma Surgery: Impact of Radiomic Shape Features and Age
by Alim Emre Basaran, Martin Vychopen, Clemens Seidel, Alonso Barrantes-Freer, Felix Arlt, Erdem Güresir and Johannes Wach
J. Clin. Med. 2025, 14(1), 40; https://doi.org/10.3390/jcm14010040 - 25 Dec 2024
Viewed by 828
Abstract
Background: Sphenoid wing meningiomas (SWM) frequently compress structures of the optic pathway, resulting in significant visual dysfunction characterized by vision loss and visual field deficits, which profoundly impact patients’ quality of life (QoL), daily activities, and independence. The objective of this study was [...] Read more.
Background: Sphenoid wing meningiomas (SWM) frequently compress structures of the optic pathway, resulting in significant visual dysfunction characterized by vision loss and visual field deficits, which profoundly impact patients’ quality of life (QoL), daily activities, and independence. The objective of this study was to assess the impact of SWM surgery on patient-reported outcome measures (PROMs) regarding postoperative visual function. Methods: The Visual Function Score Questionnaire (VFQ-25) is a validated tool designed to assess the impact of visual impairment on quality of life. The questionnaire was distributed to a previously published study population in which shape radiomics were correlated with new cranial nerve deficits after SWM surgery. Results: A total of 42 patients (42/74; 56.8%) responded to the questionnaire. Of the 42 patients, 30 were female (71%) and 12 were male (29%). The multivariable analysis demonstrated that lower sphericity reflecting irregular SWM shape was associated with poorer VFQ-25 (OR: 6.8, 95% CI: 1.141.8, p = 0.039), while age was associated with lower VFQ-25 (OR: 27, 95% CI: 2.7−272.93, p = 0.005), too. Analysis of the subcategories of the VFQ-25 revealed significantly reduced general vision (p = 0.045), social functioning (p = 0.045), and peripheral vision (p = 0.017) in those with SWM with low sphericity. Conclusions: The study highlights that SWM surgery impacts postoperative visual function, with age and irregular SWM shape being associated with poorer postoperative VFQ-25 scores. VFQ-25 is a feasible tool to assess vision outcome in SWM surgery and has clinical potential for longitudinal follow-up evaluations. Irregular SWM shape should be considered during preoperative treatment planning and patient consultation regarding functional outcome. Full article
(This article belongs to the Special Issue Neuro-Oncology: Diagnosis and Treatment)
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