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Modern Blood Banking and Transfusion in Clinical Practice
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Modern Blood Banking and Transfusion in Clinical Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 8541

Special Issue Editor

Dr. Pilar Solves

E-Mail Website
Guest Editor
Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain
Interests: blood transfusion; patient blood management; blood banking; immunohematology

Special Issue Information

Dear Colleagues,

Blood banking and transfusion practices have evolved considerably over the years. Some of the notable changes are the increasing automatization of compatibility testing and implementation of electronic systems to monitor the transfusion process from the order to the adverse effect records. Use of monoclonal antibodies such as anti-CD38 and anti-CD47 for the treatment of patients with malignancies is challenging for blood banks, since these treatments produce interferences with pre-transfusion compatibility tests delaying blood availability.

Transfusion is one of the most widely used therapies, sometimes involving inappropriate episodes. Benefits and risks have to be carefully considered when a blood transfusion is requested. During the last decade, hemovigilance systems have detected a decline in red blood cell usage that could be explained by incorporation of restrictive strategies based on current scientific evidence, among others. In fact, patient blood management programs are being progressively incorporated into the clinical practice in order to reduce unnecessary blood exposure and improve patient outcome.

The aim of this issue is to gather recent advances in blood banking laboratory and management of patients requiring a blood transfusion.

Dr. Pilar Solves
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • blood transfusion therapy
  • patient blood management
  • restrictive transfusion
  • pre-transfusion compatibility tests

Published Papers (4 papers)

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Research

10 pages, 1228 KiB  
Article
Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
by Pilar Solves, Javier Marco-Ayala, Miguel Ángel Sanz, Inés Gómez-Seguí, Aitana Balaguer-Roselló, Ana Facal, Marta Villalba, Juan Montoro, Guillermo Sanz, Javier de la Rubia and Jaime Sanz
J. Clin. Med. 2023, 12(10), 3467; https://doi.org/10.3390/jcm12103467 - 15 May 2023
Viewed by 1243
Abstract
Introduction: Transfusion plays a main role in supportive treatment for patients who receive an allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we compare the transfusion requirements of patients undergoing different modalities of HSCT according to different time periods. The objective is [...] Read more.
Introduction: Transfusion plays a main role in supportive treatment for patients who receive an allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we compare the transfusion requirements of patients undergoing different modalities of HSCT according to different time periods. The objective is to assess the evolution of HSCT transfusion requirements over time, from a single institution. Methods: The clinical charts and transfusion records of patients who underwent HSCT of different modalities at La Fe University Hospital during a twelve-year period were reviewed (2009–2020). For analysis, we divided the overall time into three periods: 1 from 2009 to 2012, 2 from 2013 to 2016 and 3 from 2017 to 2020. The study included 855 consecutive adult HSCT: 358 HLA-matched related donors (MRD), 134 HLA-matched unrelated donors (MUD), 223 umbilical cord blood transplantation (UCBT) and 140 haploidentical transplants (Haplo-HSCT). Results: There were no significant differences in RBC and PLT requirements or transfusion independence among the three time periods for MUD and Haplo-HSCT. However, the transfusion burden increased significantly for MRD HSCT during the 2017–2020 period. Conclusion: despite HSCT modalities having evolved and changed over time, overall transfusion requirements have not significantly decreased and continue to be a cornerstone of transplantation-supportive care. Full article
(This article belongs to the Special Issue Modern Blood Banking and Transfusion in Clinical Practice)
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14 pages, 1664 KiB  
Article
Predicting Vasovagal Reactions to Needles from Facial Action Units
by Judita Rudokaite, Itir Onal Ertugrul, Sharon Ong, Mart P. Janssen and Elisabeth Huis in ‘t Veld
J. Clin. Med. 2023, 12(4), 1644; https://doi.org/10.3390/jcm12041644 - 18 Feb 2023
Cited by 1 | Viewed by 1604
Abstract
Background: Merely the sight of needles can cause extreme emotional and physical (vasovagal) reactions (VVRs). However, needle fear and VVRs are not easy to measure nor prevent as they are automatic and difficult to self-report. This study aims to investigate whether a blood [...] Read more.
Background: Merely the sight of needles can cause extreme emotional and physical (vasovagal) reactions (VVRs). However, needle fear and VVRs are not easy to measure nor prevent as they are automatic and difficult to self-report. This study aims to investigate whether a blood donors’ unconscious facial microexpressions in the waiting room, prior to actual blood donation, can be used to predict who will experience a VVR later, during the donation. Methods: The presence and intensity of 17 facial action units were extracted from video recordings of 227 blood donors and were used to classify low and high VVR levels using machine-learning algorithms. We included three groups of blood donors as follows: (1) a control group, who had never experienced a VVR in the past (n = 81); (2) a ‘sensitive’ group, who experienced a VVR at their last donation (n = 51); and (3) new donors, who are at increased risk of experiencing a VVR (n = 95). Results: The model performed very well, with an F1 (=the weighted average of precision and recall) score of 0.82. The most predictive feature was the intensity of facial action units in the eye regions. Conclusions: To our knowledge, this study is the first to demonstrate that it is possible to predict who will experience a vasovagal response during blood donation through facial microexpression analyses prior to donation. Full article
(This article belongs to the Special Issue Modern Blood Banking and Transfusion in Clinical Practice)
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10 pages, 1257 KiB  
Article
Ferritin Trajectories over Repeated Whole Blood Donations: Results from the FIND+ Study
by Sara Moazzen, Maike G. Sweegers, Mart Janssen, Boris M. Hogema, Trynke Hoekstra and Katja Van den Hurk
J. Clin. Med. 2022, 11(13), 3581; https://doi.org/10.3390/jcm11133581 - 21 Jun 2022
Cited by 2 | Viewed by 1893
Abstract
Background: Depending on post-donation erythropoiesis, available iron stores, and iron absorption rates, optimal donation intervals may differ between donors. This project aims to define subpopulations of donors with different ferritin trajectories over repeated donations. Methods: Ferritin levels of 300 new whole blood donors [...] Read more.
Background: Depending on post-donation erythropoiesis, available iron stores, and iron absorption rates, optimal donation intervals may differ between donors. This project aims to define subpopulations of donors with different ferritin trajectories over repeated donations. Methods: Ferritin levels of 300 new whole blood donors were measured from stored (lookback) samples from each donation over two years in an observational cohort study. Latent classes of ferritin level trajectories were investigated separately using growth mixture models for male and female donors. General linear mixed models assessed associations of ferritin levels with subsequent iron deficiency and/or low hemoglobin. Results: Two groups of donors were identified using group-based trajectory modeling in both genders. Ferritin levels showed rather linear reductions among 42.9% of male donors and 87.7% of female donors. For the remaining groups of donors, steeper declines in ferritin levels were observed. Ferritin levels at baseline and the end of follow-up varied greatly between groups. Conclusions: Repeated ferritin measurements show depleting iron stores in all-new whole blood donors, the level at which mainly depends on baseline ferritin levels. Tailored, less intensive donation strategies might help to prevent low iron in donors, and could be supported with ferritin monitoring and/or iron supplementation. Full article
(This article belongs to the Special Issue Modern Blood Banking and Transfusion in Clinical Practice)
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11 pages, 298 KiB  
Article
Epidemiology and Associated Factors in Transfusion Management in Intensive Care Unit
by Raúl Juárez-Vela, Eva María Andrés-Esteban, Ivan Santolalla-Arnedo, Regina Ruiz de Viñaspre-Hernández, Carmen Benito-Puncel, Ainhoa Serrano-Lázaro, Pilar Marcos-Neira, Alba López-Fernández, Clara Isabel Tejada-Garrido, Juan Luis Sánchez-González, Manuel Quintana-Díaz and José Antonio García-Erce
J. Clin. Med. 2022, 11(12), 3532; https://doi.org/10.3390/jcm11123532 - 20 Jun 2022
Cited by 1 | Viewed by 1488
Abstract
Severe traumatic injury is one of the main global health issues which annually causes more than 5.8 million worldwide deaths. Uncontrolled haemorrhage is the main avoidable cause of death among severely injured individuals. Management of trauma patients is the greatest challenge in trauma [...] Read more.
Severe traumatic injury is one of the main global health issues which annually causes more than 5.8 million worldwide deaths. Uncontrolled haemorrhage is the main avoidable cause of death among severely injured individuals. Management of trauma patients is the greatest challenge in trauma emergency care, and its proper diagnosis and early management of bleeding trauma patients, including blood transfusion, are critical for patient outcomes. Aim: We aimed to describe the epidemiology of transfusion practices in severe trauma patients admitted into Spanish Intensive Care Units. Material and Methods: We performed a multicenter cross-sectional study in 111 Intensive Care Units across Spain. Adult patients with moderate or severe trauma were eligible. Distribution of frequencies was used for qualitative variables and the mean, with its 95% CI, for quantitative variables. Transfusion programmes, the number of transfusions performed, and the blood component transfused were recorded. Demographic variables, mortality rate, hospital stay, SOFA-score and haemoglobin levels were also gathered. Results: We obtained results from 109 patients. The most transfused blood component was packet red blood cells with 93.8% of total transfusions versus 43.8% of platelets and 37.5% of fresh plasma. The main criteria for transfusion were analytical criteria (43.75%), and acute anaemia with shock (18.75%) and without haemodynamic impact (18.75%). Conclusion: Clinical practice shows a ratio of red blood cells, platelets, and Fresh Frozen Plasma (FFP) of 2:1:1. It is necessary to implement Massive Transfusion Protocols as they appear to improve outcomes. Our study suggests that transfusion of RBC, platelets and FFP in a 2:1:1 ratio could be beneficial for trauma patients. Full article
(This article belongs to the Special Issue Modern Blood Banking and Transfusion in Clinical Practice)
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