Special Issue "Bipolar Disorder: Controversies and Unmet Needs"
Deadline for manuscript submissions: 1 August 2021.
Interests: long-term management of bipolar disorder and schizoaffective disorder; bipolar type; sleep-, biorhythm and energy-related clinical, neurobiological, and digital alterations in bipolar disorders
In the last several decades, psychiatric disorders pertaining to the bipolar affective spectrum have seen a strong impulse in research, which translated into improved standards of diagnosis, prognosis, and care of patients affected by bipolar disorders (BDs). Despite these progresses, research on BDs still fails to provide evidence-based conclusions allowing for good reliability in diagnosis or anchoring any attempt of prognosis with validated course markers. Heterogeneous courses and outcomes of illness follow the diagnosis of BDs, which embraces patients with milder affective disorders, as well as patients with severe manifestations with psychotic symptoms persisting beyond acute episodes defined as schizoaffective. There are treatments specifically approved for BDs, yet part of the therapeutic management still relies on drugs investigated on the basis of acute cross-sectional similarities with major depression, as in the case of antidepressants. Efforts to consolidate neurobiological underpinnings of this syndrome reinforce the possibility of a stratification of patients within the diagnostic framework of BDs.
The present Special Issue aims to explore the neglected or understudied topics which still appear problematic and scarcely explored in BDs, including but not limited to the diagnostic boundaries of the spectrum (schizoaffective disorder bipolar type on one side, cyclothymia and recurring depression on the other), the specific characteristics of BD type II, the role of comorbidities, especially with personality disorders, the possible definition of the BD diagnosis with a neurobiology-based framework as the RDoC initiative, the possible implementation of staging models and stage-specific treatments, and the methodological pitfalls in treatment trial design for BDs.
Dr. Andrea Murru
Manuscript Submission Information
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- bipolar disorders
- schizoaffective disorder
- psychiatric disorders