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Fresh Insights in Skin Disease
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Fresh Insights in Skin Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1142

Special Issue Editor

Dr. Claudio Marasca

E-Mail Website
Guest Editor
Dermatology Unit, Medical Department, “Antonio Cardarelli” National Hospital, Naples, Italy
Interests: dermatology; hidradenitis; psoriasis; biologic drugs; dermoscopy; ultrasonography; teledermatology; melanoma; skin tumors; basal cell carcinoma; wound care; inflammatory skin disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin diseases cover a wide, complex range, from common inflammatory disorders to rare genetic syndromes and life-threatening neoplasms. The Special Issue "Fresh Insights in Skin Disease" intends to present the latest advances in pathogenesis, diagnosis, and management across dermatologic conditions.

Contributions exploring novel mechanisms of inflammatory dermatoses, autoimmune skin conditions, skin cancers, and infectious diseases are welcome. Original research on the skin microbiome, emerging biomarkers, and targeted therapies (including biologics and small molecules) is particularly encouraged. Reviews highlighting diagnostic challenges or new therapeutic strategies with translational relevance are also invited.
Special attention will be paid to interdisciplinary approaches integrating dermatology with immunology, oncology, genetics, and digital health. Studies using artificial intelligence, dermoscopy, or teledermatology to enhance diagnostic accuracy and patient care are of great interest.

By gathering diverse perspectives and cutting-edge research, this Special Issue aims to offer clinicians and researchers a comprehensive, forward-looking view of the evolving dermatology landscape.

Dr. Claudio Marasca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory dermatoses
  • dermoscopy
  • melanoma
  • autoimmune skin conditions
  • psoriasis
  • skin cancers
  • skin syndromes

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Published Papers (1 paper)

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8 pages, 629 KB  
Case Report
Persistent Liver Manifestations in Allopurinol-Induced Sweet’s Syndrome: An Uncommon Case Report
by Amalia Papanikolopoulou, Sofia M. Siasiakou, Kosmas Pantazopoulos, Ioannis P Trontzas, Eleni Fyta, Oraianthi Fiste, Ekaterini Syrigou and Nikolaos Syrigos
J. Clin. Med. 2025, 14(20), 7186; https://doi.org/10.3390/jcm14207186 - 12 Oct 2025
Cited by 1 | Viewed by 965
Abstract
Background/Objectives: Sweet’s syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder that may also present with extracutaneous manifestations. Liver involvement is thought to result from sterile neutrophilic infiltration, mirroring the skin pathology and highlighting the syndrome’s systemic [...] Read more.
Background/Objectives: Sweet’s syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder that may also present with extracutaneous manifestations. Liver involvement is thought to result from sterile neutrophilic infiltration, mirroring the skin pathology and highlighting the syndrome’s systemic inflammatory nature. Timely recognition, exclusion of infectious or autoimmune etiologies, and prompt corticosteroid therapy are critical for favorable outcomes. Methods: Herein, we present the case of a 73-year-old man with hyperuricemia who developed both cutaneous and systemic manifestations of SS seven days after initiating allopurinol treatment. His symptoms included fever, conjunctivitis in the right eye, and painful, non-pruritic erythematous plaques, some with pustules, on the lower limbs, palms, and face. Results: Initial laboratory investigations revealed neutrophilic leukocytosis, elevated inflammatory markers, and renal and hepatic dysfunction. Empirical treatment with antibiotics and antivirals failed to improve his condition. The patient discontinued allopurinol and initiated a high-dose corticosteroid regimen, leading to rapid resolution of fever and improvement in skin lesions. Laboratory parameters gradually normalized, except for persistent high liver enzymes. A comprehensive diagnostic workup ruled out infectious, autoimmune, and malignant causes. Imaging studies, including CT, MRI, and MRCP, showed no structural liver abnormalities. Skin biopsy findings were consistent with SS, demonstrating dense neutrophilic infiltrates in the reticular dermis and papillary dermal edema. After his discharge, he was followed up by the Hepatology unit. The patients’ liver enzyme levels normalized within three months with no recurrence or late complications one year later. Conclusions: In the context of drug-induced SS, persistent hepatic abnormalities, although rare, may occur in patients without underlying liver disease. Full article
(This article belongs to the Special Issue Fresh Insights in Skin Disease)
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