Liquid Biopsies in Oral Cancer: Advances and New Perspectives
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 302
Special Issue Editor
2. Department of Surgery and Medical-Surgical Specialties, Medicine and Dentistry School, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain
3. Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal
4. Medical Devices Research Group, International Iberian Nanotechnology Laboratory (INL), 4715-330 Braga, Portugal
Interests: liquid biopsy; salivary biomarkers; oral cancer; circulating biomarkers; HPV; precision oncology; microRNAs; DNA methylation; cell-free DNA; head and neck cancer
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Special Issue Information
Dear Colleagues,
Oral cancer is a growing public health problem, with more than 389,000 new cases and 188,000 deaths annually worlwide. Despite advances in its diagnosis and treatment, the five-year survival rate has not yet improved and remains accurate in around 50% of cases, mainly due to high rates of late diagnosis and disease relapse. Further, there is an urgent need for accurate and non-invasive biomarkers to improve early detection and prognosis of oral cancer, as well as reliable predictive biomarkers that may enhance treatment efficacy and improve patient outcomes. Liquid biopsies have recently gained significant interest in the field of oncology due to their potential for early cancer detection, treatment selection, and disease monitoring. Liquid biopsy of blood and/or saliva has emerged as an atractive strategy for detecting and analyzing different biomarkers in oral cancer, including circulating tumor cells (CTCs), cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA), cell-free RNA (cfRNA), proteins, and extracellular vesicles (EVs) using genetic, epigenetic, proteomic, transcriptomic, microbiomic, or metabolomic approaches. Therefore, we invite you to contribute to this Special Issue of Journal of Clinical Medicine focused on the latest clinical, molecular, and technological research advances in liquid biopsies in oral cancer.
Original research, comprehensive reviews, systematic reviews, and meta-analyses are welcome.
Dr. Óscar Rapado-González
Guest Editor
Manuscript Submission Information
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Keywords
- oral cancer
- oral potentially malignant disorders
- liquid biopsies
- saliva and blood biomarkers
- circulating tumor cells (CTCs)
- cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA)
- cell-free RNA (cfRNA)
- extracellular vesicles (EVs)
- genetic and epigenetic biomarkers
- early detection
- prognosis and therapy response prediction
- precision medicine
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