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New Therapies for Diabetic Foot Ulcer Management
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New Therapies for Diabetic Foot Ulcer Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 2258

Special Issue Editors

Prof. Dr. Irene Sanz-Corbalan

E-Mail Website
Guest Editor
1. Diabetic Foot Unit, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain
2. Health Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain
Interests: diabetic foot; diabetic foot osteomyelitis; diabetic neuropathy; diabetic foot care
Special Issues, Collections and Topics in MDPI journals
Dr. Raúl J. Molines Barroso

E-Mail Website
Guest Editor
1. Diabetic Foot Unit, Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain
2. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain
Interests: diabetic foot; diabetic foot ulcers; diabetic foot prevention; diabetic foot ostemyelitis; biomechanics; charcot foot
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetic foot disease is one of the major complications of diabetes mellitus, significantly impacting patients' quality of life and healthcare systems. Despite advancements in diagnosis and treatment, it remains a clinical challenge due to its high morbidity and risk of amputation. This Special Issue aims to compile current research and reviews on the latest developments in the prevention, diagnosis, and management of diabetic foot disease. Topics will include new therapeutic strategies, innovations in ulcer treatment, the use of biomarkers, emerging technologies in monitoring, and the microbiology of diabetic foot infections. Additionally, the issue will explore the role of telemedicine, artificial intelligence, and patient care in preventing complications. We invite researchers and clinicians to contribute original research articles and systematic reviews that expand knowledge on this condition and highlight the most promising therapeutic approaches.

Prof. Dr. Irene Sanz-Corbalan
Dr. Raúl J. Molines Barroso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic foot disease
  • diabetic foot ulcers
  • wound healing
  • biomarkers
  • telemedicine
  • artificial intelligence
  • preven-tive strategies
  • advanced therapies
  • amputation prevention
  • diabetes complications
  • novel treatments

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Published Papers (1 paper)

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Research

11 pages, 765 KB  
Article
Comparing the Diagnostic Accuracy of the Probe-to-Bone Test, Plain Radiography, and Serum Biomarkers in Detecting Diabetic Foot Osteomyelitis
by María Herrera-Casamayor, Irene Sanz-Corbalán, Aroa Tardáguila-García, Mateo López-Moral, José Luis Lázaro-Martínez and Yolanda García-Álvarez
J. Clin. Med. 2026, 15(2), 500; https://doi.org/10.3390/jcm15020500 - 8 Jan 2026
Viewed by 1686
Abstract
Background/Objectives: diabetic foot osteomyelitis (DFO) is a serious complication characterized by bone infection that can involve cortical structures, bone marrow, and surrounding soft tissues. Its prevalence ranges from 20% in moderate diabetic foot infections to over 50% in severe cases, making accurate diagnosis [...] Read more.
Background/Objectives: diabetic foot osteomyelitis (DFO) is a serious complication characterized by bone infection that can involve cortical structures, bone marrow, and surrounding soft tissues. Its prevalence ranges from 20% in moderate diabetic foot infections to over 50% in severe cases, making accurate diagnosis essential in guiding timely and effective management. in this study, we aimed to evaluate the diagnostic accuracy achieved by combining the probe-to-bone (PTB) test, plain radiography, and blood biomarkers—including the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)—in the diagnosis of DFO. Methods: we conducted a diagnostic accuracy study involving 128 patients with diabetic foot ulcers and clinical suspicion of DFO. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated for individual tests and for their diagnostic combinations. Results: the combination of PTB and biomarkers yielded a sensitivity of 75%, a specificity of 24%, a positive predictive value of 69%, and a negative predictive value of 29%. Similarly, the combination of PTB and plain radiography showed a sensitivity of 76%, a specificity of 23%, a positive predictive value of 62%, and a negative predictive value of 38%. When the three diagnostic modalities were analyzed together, the sensitivity reached 75%, and the specificity reached 23%. Conclusions: the combination of PTB and inflammatory biomarkers demonstrated moderate effectiveness and diagnostic performance comparable to PTB combined with radiography. These findings suggest that biomarkers may serve as a practical and accessible diagnostic adjunct in settings where imaging availability is limited or radiographic interpretation is challenging. Full article
(This article belongs to the Special Issue New Therapies for Diabetic Foot Ulcer Management)
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