Bone and Spine Metastases

Dear Colleagues,

The incidence and prevalence of bone metastases have been rising because cancer-carrying patients have a longer life expectancy owing to recent advances in treatment and diagnosis. Bone metastases can cause pathological fractures, spinal cord compression, and hypercalcemia, leading to serious symptoms including neurological dysfunction and intractable pain. The spine is the most common site of bone metastases, and these symptoms impair the health status and quality of life of patients, the addressal of which is the goal of multidisciplinary treatment for bone and spine metastases. However, there is still room for improvement in the treatment of bone and spine metastases. Further research on surgery, radiotherapy, and systemic treatment, including anti-tumor drugs, molecular targeted drugs, and bone‐modifying agents, is warranted. Additionally, it is extremely valuable to understand the biology of bone metastases and to develop new treatments with fewer and/or less-severe side effects. The goal of this Special Issue is to improve clinical outcomes and propose a new strategy for bone and spine metastases.

You may choose our Joint Special Issue in Cancers.

Dr. Kenichiro Kakutani
Dr. Yutaro Kanda
Guest Editors

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• bone metastases
• spinal metastases
• stereotactic body radiotherapy
• conventional radiotherapy
• spine surgery
• spondylectomy
• minimally invasive surgery
• particle-beam radiotherapy
• systemic agents
• microenvironment