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Clinical Advances in Gingivitis
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Clinical Advances in Gingivitis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: closed (10 April 2025) | Viewed by 1035

Special Issue Editor

Prof. Dr. Denis Bourgeois

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Guest Editor
Health, Systemic, Process, UR4129 Research Unit, University Claude Bernard Lyon 1, University of Lyon, Lyon, France
Interests: chronic diseases; periodontology; oral microbiome; individual prophylaxis; eating behavior disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to announce a new Special Issue focusing on the latest advances in gingivitis. This Special Issue aims to gather research and innovative approaches that will enhance our understanding and management of this periodontal health condition. We kindly invite researchers, clinicians, and academics to contribute their original research and reviews. In this Special Issue, we aim to cover a broad spectrum of topics, including, but not limited to, the following: (i) research exploring the underlying biological processes and genetic factors contributing to gingivitis; (ii) innovations in diagnostic methods, including biomarkers, imaging technologies, and artificial intelligence applications; and (iii) studies focusing on prevention, including oral hygiene practices, dietary interventions, and public health initiatives. In addition, we would be interested in advances in treatment modalities, such as pharmacological interventions, minimally invasive procedures, and novel therapeutic agents. We would also like to explore collaborative studies that bridge the gap between periodontology and other medical subjects, with a view to highlighting the systemic impact of gingivitis.

Prof. Dr. Denis Bourgeois
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • inflammation
  • microbiota
  • nutrition
  • pathogens
  • prophylaxis
  • interdental space
  • systemic disease

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Published Papers (1 paper)

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Research

12 pages, 1452 KiB  
Article
Edentulism or Poor Oral Hygiene: Which Is the Stronger Predictor for All-Cause Mortality?
by Sok-Ja Janket, Hasna H. Kunhipurayil, Faleh Tamimi, Markku Surakka, Huiqi Li, Thomas E. Van Dyke and Jukka H. Meurman
J. Clin. Med. 2025, 14(2), 371; https://doi.org/10.3390/jcm14020371 - 9 Jan 2025
Viewed by 744
Abstract
Background: All-cause mortality consisting of several heterogeneous subgroups does not have a well-defined set of risk factors. Despite the well-described role of oral hygiene on mortality, the association between the condition of the existing dentition and mortality remains unclear. Therefore, we embarked [...] Read more.
Background: All-cause mortality consisting of several heterogeneous subgroups does not have a well-defined set of risk factors. Despite the well-described role of oral hygiene on mortality, the association between the condition of the existing dentition and mortality remains unclear. Therefore, we embarked on the current study to assess the association of oral hygiene self-care (OHS) with all-cause mortality. Methods: We assessed whether edentulism and the levels of OHS are associated with all-cause mortality in 476 subjects without missing values participating in the KOHH study using proportional hazard models. We designated the edentulous group as OHS0, and poor, fair, and good OHS groups as OHS1, OHS2, and OHS3, respectively. The self-reported OHS was validated against clinical measures of oral inflammation and dental cleanliness, i.e., gingival bleeding and plaque indices. We, then, compared all-cause mortality at three levels of OHS (poor, fair, good) to that of the edentulous group. To test whether the association of OHS to all-cause mortality was mediated by inflammation, we adjusted for CRP. Results: The validity of self-reported OHS was good demonstrating an inverse association with gingival inflammation and plaque index in a dose-response manner. The group with good OHS lived significantly longer, with a 50% lower risk of all-cause mortality. The Hazard ratio (HR) = 0.50 (95% confidence limit: 0.25–0.99), p = 0.045, in a model adjusted for age, smoking, body mass index, and education. Adjusting for CRP attenuated the association of OHS to all-cause mortality slightly, suggesting that this association was mediated, at least in part, by inflammation. In the final model, the poor OHS group exhibited HR = 0.98 (0.51–1.89), p = 0.95. The HR and p-value so close to 1 suggested poor OHS has a similar risk to edentulism. Conclusions: OHS was associated with reduced risk for all-cause mortality: the better OHS, the lower the risk for all-cause mortality. Poor oral hygiene showed a similar risk for all-cause mortality to edentulism. Full article
(This article belongs to the Special Issue Clinical Advances in Gingivitis)
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