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Breast Cancer: Clinical Diagnosis and Personalized Therapy
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Breast Cancer: Clinical Diagnosis and Personalized Therapy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 29 September 2024 | Viewed by 707

Special Issue Editor

Dr. Edy Ippolito

E-Mail Website
Guest Editor
Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy
Interests: breast cancer; lung cancer; radiotherapy; advanced technology; radiation induced toxicity; concomitant treatments

Special Issue Information

Dear Collegues,

Breast cancer treatment has significantly changed and expanded in the last few decades, mainly due to the increased understanding of the molecular factors contributing to breast cancer pathogenesis and heterogeneity. Although overall survival has improved due to advanced diagnostic modalities as well as the introduction of tailored treatements directed at specific patient populations, there is still room for improvement.

This Special Issue addresses the topic of precision medicine and novel research in the field of diagnosis, predictive biomarkers, loco-regional treatment (radiation and surgery), and systemic treatments.

Dr. Edy Ippolito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • imaging biomarkers
  • molecular biomarkers
  • precision medicine
  • loco-regional treatment
  • breast surgery
  • breast radiotherapy

Published Papers (1 paper)

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Research

23 pages, 5602 KiB  
Article
Traditional Clinicopathological Biomarkers Still Determine Disease-Free and Overall Survival in Invasive Breast Cancer Patients: A Pilot Study
by Katarzyna Wrzeszcz, Katarzyna Kwiatkowska, Piotr Rhone, Dorota Formanowicz, Stefan Kruszewski and Barbara Ruszkowska-Ciastek
J. Clin. Med. 2024, 13(7), 2021; https://doi.org/10.3390/jcm13072021 - 30 Mar 2024
Viewed by 494
Abstract
Background: Molecular classification, tumor diameter, Ki67 expression, and brachytherapy administration still act as the most potent potential predictors of breast cancer recurrence and overall survival. Methods: Over the period of 23 months, we included in the study 92 invasive breast cancer (IBrC) patients [...] Read more.
Background: Molecular classification, tumor diameter, Ki67 expression, and brachytherapy administration still act as the most potent potential predictors of breast cancer recurrence and overall survival. Methods: Over the period of 23 months, we included in the study 92 invasive breast cancer (IBrC) patients initially diagnosed at the Clinical Ward of Breast Cancer and Reconstructive Surgery, Oncology Center in Bydgoszcz, Poland. The probability of disease-free survival (DFS) and overall survival (OS) in relation to potential prognostic factors for the patients were determined using a Kaplan–Meier analysis, and univariate and multivariate Cox regression analyses evaluated the predictive factors of IBrC patients. The investigation of the potential prognostic model’s accuracy was analyzed using the ROC curve. Results: Patients with tumor size < 2 cm, Ki67 expression < 20%, luminal-A molecular subtype, and extra-dose brachytherapy boost administration displayed the most favorable prognosis according to breast cancer disease-free survival and overall survival. The estimated 5 year probability of DFS and OS rates in women with tumor diameter < 2 cm were 89% and 90%, respectively. In tumor diameter > 2 cm, the estimated 5 year probability of DFS was 73% and OS was 76%. Interestingly, the tumor diameter of 1.6 cm with a specificity of 60.5% and a sensitivity of 75% occurred as the best threshold point to differentiate patients with cancer recurrence from those without cancer progression. Conclusions: Our study provides essential information on the clinicopathological profile and future outcomes of early stage IBrC patients. Furthermore, the tumor diameter cut-off value of 1.6 cm discriminating between disease recurrence and those without disease progression patients represents an innovative direction for further research. Full article
(This article belongs to the Special Issue Breast Cancer: Clinical Diagnosis and Personalized Therapy)
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