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Relationship between Coronary Artery Calcification and Coronary Artery Disease: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 2005

Special Issue Editor


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Guest Editor
Second Department of Cardiology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
Interests: interventional cardiology; percutaneous coronary intervention (PCI); acute myocardial infarction; acute coronary syndromes; transcatheter interventions; structural interventions; cardiovascular diseases; advanced coronary imaging techniques
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Special Issue Information

Dear Colleagues,

Coronary artery calcification (CAC) is a highly prevalent pathophenotype that is associated with aging, diabetes mellitus, chronic kidney disease, and coronary artery disease (CAD). When present, it portends a worse clinical outcome and predicts major adverse cardiovascular events.

Calcified coronary lesions continue to represent a challenge for percutaneous coronary intervention (PCI), as they are difficult to dilate, and it is difficult to deliver and implant drug-eluting stents properly. Poor stent deployment is associated with high rates of periprocedural complications and suboptimal long-term clinical outcomes.

Due to the introduction of several adjunctive PCI tools, such as cutting/scoring/high-pressure non-compliant/lithotripsy balloons and atherectomy devices, the treatment of such lesions has become increasingly feasible, predictable, and safe.

Intravascular imaging can identify the need for calcium-modifying therapies and can assess the type of in addition to response to therapy as well as the final stent result.

In this Special Issue, we welcome authors to submit papers on the relationship between coronary artery calcification and coronary artery disease, from diagnosis to treatment.

Dr. George Kassimis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary calcification
  • intracoronary imaging
  • atherectomy
  • intravascular lithotripsy
  • cutting balloon
  • scoring balloon
  • high-pressure non-compliant balloon

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Published Papers (1 paper)

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Review

21 pages, 1170 KiB  
Review
From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease
by Andreas Mitsis, Elina Khattab, Evi Christodoulou, Kimon Myrianthopoulos, Michael Myrianthefs, Stergios Tzikas, Antonios Ziakas, Nikolaos Fragakis and George Kassimis
J. Clin. Med. 2024, 13(21), 6352; https://doi.org/10.3390/jcm13216352 - 23 Oct 2024
Cited by 2 | Viewed by 1610
Abstract
Coronary artery calcification (CAC) is a hallmark of atherosclerosis and a critical factor in the development and progression of coronary artery disease (CAD). This review aims to address the complex pathophysiological mechanisms underlying CAC and its relationship with CAD. We examine the cellular [...] Read more.
Coronary artery calcification (CAC) is a hallmark of atherosclerosis and a critical factor in the development and progression of coronary artery disease (CAD). This review aims to address the complex pathophysiological mechanisms underlying CAC and its relationship with CAD. We examine the cellular and molecular processes that drive the formation of calcified plaques, highlighting the roles of inflammation, lipid accumulation, and smooth muscle cell proliferation. Additionally, we explore the genetic and environmental factors that contribute to the heterogeneity in CAC and CAD presentation among individuals. Understanding these intricate mechanisms is essential for developing targeted therapeutic strategies and improving diagnostic accuracy. By integrating current research findings, this review provides a comprehensive overview of the pathways linking CAC to CAD, offering insights into potential interventions to mitigate the burden of these interrelated conditions. Full article
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