Migraine Headache: Symptoms, Diagnosis, and Current Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 625

Special Issue Editor


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Guest Editor
1. Department of Neurology, Pauls Stradiņš Clinical University Hospital, Pilsoņu iela 13, LV-1002 Riga, Latvia
2. Department of Anaesthesiology and Intensive Care, Rīga Stradiņš University, LV-1007 Riga, Latvia
Interests: headaches; pain; neuropathic pain; musculoskeletal disorders

Special Issue Information

Dear Colleagues,

Headaches are one of the most common health complaints and are listed among the WHO’s major causes of disability with a global prevalence of 47% (symptoms occurring at least once in the past year). In particular, migraines are especially debilitating in women and young people aged between 15–49 years. They have a great social and economic impact on family life, partnership, educational and employment choices, and work productivity.

There are challenges in headache care on all levels. Migraine and other primary headaches are under-recognized as a problem by patients and physicians in many cases. Clinicians often lack interest and become frustrated seeing headache patients. Diagnosis failure leads to patients not receiving an accurate diagnosis, resulting in under-diagnosed primary headaches and over-diagnosed secondary headaches (such as cervicogenic headaches, or attributed to arterial hypertension, refractive error, or sinusitis, etc.). Lack of timely precise headache disorder diagnosis leads to delayed and inadequate treatment or under-treated migraines and other headache disorders, which require acute and preventive medications and non-pharmacological approaches. This, in turn, creates risks of chronic migraines, other primary headaches, and medication overuse headaches.

In this Special Issue of the Journal of Clinical Medicine, we are offering a platform to highlight the broad diversity of research performed across this field. This Special Issue will focus on new insights, current challenges and controversies, recent advances, and future perspectives in the field of migraine and other headache disorders. We anticipate that the research presented will promote fruitful discussions in the maternal-fetal medical community that will translate into the adoption of best practice applications in clinical, public health, and policy settings.

Prof. Dr. Ināra Logina
Guest Editor

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Keywords

  • migraine
  • headache disorders
  • burden of headache disorders
  • acute and preventive treatment of migraine
  • neuropathic pain

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Published Papers (1 paper)

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18 pages, 1214 KiB  
Systematic Review
A Correlation Between Migraine and Endometriosis and Its Clinical Implications—A Systematic Literature Review
by Ewelina Lechowicz, Aleksander Łaciński, Antonina Smulska, Olga Grodzka and Izabela Domitrz
J. Clin. Med. 2025, 14(8), 2744; https://doi.org/10.3390/jcm14082744 - 16 Apr 2025
Viewed by 315
Abstract
Background/Objectives: Migraine and endometriosis are two diseases that are associated with women. Endometriosis is a condition exclusively affecting the female population as it affects the female genital tract, while migraine is a primary headache disorder having the highest prevalence in women of reproductive [...] Read more.
Background/Objectives: Migraine and endometriosis are two diseases that are associated with women. Endometriosis is a condition exclusively affecting the female population as it affects the female genital tract, while migraine is a primary headache disorder having the highest prevalence in women of reproductive age. Although, undoubtedly, they are two distinct disorders, some correlations have been suggested considering the epidemiological similarities. Methods: This systematic review aimed to analyze the putative links between those two diseases. Two databases were searched in accordance with the PRISMA guidelines, which led to the inclusion of 28 of the most appropriate studies. The review was registered in PROSPERO. Results: A comprehensive analysis of the existing literature allowed us to distinguish six different aspects: (i) the prevalence of migraine in the course of endometriosis, in general, (ii) when comparing endometriosis patients to healthy individuals, (iii) the relation between different migraine types and endometriosis, (iv) pain symptoms in patients with endometriosis and migraine, and finally, (v) molecular and (vi) genetic bases of the suspected correlation. Conclusions: Although not all results are definitely apparent, the results showed a higher prevalence of endometriosis and migraine together than both diseases separately. More precisely, chronic migraine was demonstrated to be the most possibly linked to endometriosis. Moreover, pain symptoms were usually more evident in patients suffering from both diseases at the time. Finally, some suggestions were presented due to this comorbidity’s molecular and genetic bases; however, the literature, especially on this topic, is lacking. Full article
(This article belongs to the Special Issue Migraine Headache: Symptoms, Diagnosis, and Current Treatment)
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