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New Advances in the Diagnosis and Treatment of Breast Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (17 October 2025) | Viewed by 662

Special Issue Editors


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Guest Editor
Breast Surgery Unit, Veneto Institute of Oncology IOV, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy
Interests: breast surgery; breast cancer; intraoperative ultrasound; oncoplastic and reconstructive breast surgery; new technologies in breast cancer treatment

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Guest Editor
Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10001, USA
Interests: breast surgery; breast cancer; oncoplastic and reconstructive breast surgery; axillary surgery de-escalation; neo-adjuvant chemotherapy

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Guest Editor
Division of Breast Surgery, Rome Catholic University School of Medicine, Rome, Italy
Interests: breast surgery; breast cancer; breast surgery de-escalation; neoadjuvant chemotherapy; new technologies in breast cancer treatment
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Breast Surgery Unit, Veneto Institute of Oncology IOV, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy
Interests: breast surgery; breast cancer; intraoperative ultrasound; oncoplastic and reconstructive breast surgery; new technologies in breast cancer treatment

Special Issue Information

Dear Colleagues,

Advancements in breast cancer diagnosis and treatment have significantly improved oncological outcomes and patients’ quality of life.

Innovative imaging technologies and refined genetic testing have enhanced early detection, enabling more personalized approaches.

Surgical management is shifting toward de-escalation, particularly in axillary surgery, with new technologies improving breast-conserving surgery guidance and reducing positive margin rates. The growing adoption of prepectoral implant reconstruction, ongoing research into periprosthetic matrices, and the emerging use of endoscopic and robotic-assisted techniques show promise in minimizing surgical impact and enhancing patient satisfaction. Advanced oncoplastic techniques, such as chest wall perforator flaps, represent innovative options for extended partial breast reconstructions, contributing to reduced mastectomy rates.

The evolution of oncological therapies, especially in the neoadjuvant setting, has shown impressive efficacy, sparking discussions about the possibility of omitting surgery in selected exceptional responders. Concurrently, targeted therapies and immunotherapy are transforming systemic treatments, offering highly effective, tumor-specific options. Radiotherapy is also progressing toward more tailored treatments, reducing side effects while maximizing benefits.

Lifestyle factors, including diet and physical activity, are emerging as key elements in breast cancer prevention and treatment.

Artificial intelligence is revolutionizing breast cancer care, enhancing early detection, personalizing treatments, and improving surgical and diagnostic outcomes through predictive analytics and innovative applications in imaging and pathology.

This Special Issue invites submissions that explore these cutting-edge topics, including:

  • Innovative diagnostic tools and imaging techniques;
  • Advances in surgical oncology, oncoplastic, and reconstructive techniques;
  • Emerging systemic therapies, including immunotherapy and targeted treatments;
  • Progress in radiation oncology and tailored radiotherapy approaches;
  • Lifestyle factors impacting prevention and treatment outcomes;
  • Artificial intelligence in diagnosis, treatment planning, and surgery;
  • Quality of life, survivorship, and patient-centered care strategies.

We look forward to your valuable contributions to enrich clinical practice and shape the future of breast cancer management.

Dr. Massimo Ferrucci
Dr. Giacomo Montagna
Prof. Dr. Gianluca Franceschini
Dr. Alberto Marchet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • innovative imaging technologies
  • personalized treatment approaches
  • surgical de-escalation
  • onco-plastic and reconstructive surgery
  • targeted therapies
  • immunotherapy
  • artificial intelligence
  • radiotherapy ad-vancements
  • lifestyle factors

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Published Papers (1 paper)

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Research

16 pages, 2028 KB  
Article
Enhancing Timeliness and Compliance of Osteoporosis Care in Oncology: Evidence from a Dedicated Bone Health Service
by William Balzi, Valentina Danesi, Andrea Roncadori, Ilaria Massa, Roberta Maltoni, Nicola Gentili, Martina Cavallucci, Alice Andalò, Laura Ridolfi, Venetia Zavoiu, Maria Cristina Focherini, Raffaele Giannini, Enrico Campadelli, Stefano Tamberi and Sebastiano Calpona
J. Clin. Med. 2025, 14(18), 6564; https://doi.org/10.3390/jcm14186564 - 18 Sep 2025
Viewed by 386
Abstract
Background/Objectives: Management of cancer treatment-induced bone loss (CTIBL) is essential for preserving quality of life among breast cancer (BC) patients receiving endocrine therapy. However, bone-modifying agents (BMAs) remain underused and delayed. In 2014, IRST launched the first bone health outpatient service in [...] Read more.
Background/Objectives: Management of cancer treatment-induced bone loss (CTIBL) is essential for preserving quality of life among breast cancer (BC) patients receiving endocrine therapy. However, bone-modifying agents (BMAs) remain underused and delayed. In 2014, IRST launched the first bone health outpatient service in Romagna (the eastern area of the Emilia-Romagna region). A multi-centre, retrospective observational study with propensity score matching (PSM) was conducted to evaluate the impact of the IRST organisational model on bone health. Methods: The PSM matched the Emilia-Romagna patients who underwent BC surgery between 2014 and 2022 and were in follow-up in the Romagna area. Patients were grouped as follows: (1) IRST and (2) other Romagna hospitals (without bone health service, i.e., the control group). The matching was based on age, in situ/invasive cancer, and type of early-stage treatment (hormone treatment vs. chemotherapy). Logistic regression and Cox proportional-hazard models assessed factors associated with bone care treatment initiation and timings, respectively. Results: After PSM, we matched 3112 of the 8021 eligible patients into the two cohorts. IRST patients were 39% more likely to receive BMAs (OR: 1.393; 95% CI: 1.236–1.571) and initiated treatment approximately 12 months earlier. We observed that patients with invasive tumours were 77% more likely to initiate bone therapy than those with in situ tumours (OR: 1.766; 95% CI: 1.237–2.585). The early initiation of bone health therapy was influenced by age (p < 0.001) and neoadjuvant chemotherapy treatment (p < 0.001). Conclusions: The IRST model demonstrates responsiveness to bone health needs in BC patients and may be implemented elsewhere to support integrated CTIBL care. Full article
(This article belongs to the Special Issue New Advances in the Diagnosis and Treatment of Breast Cancer)
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