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Shaping Modern Gastroenterology: Bridging Advancements in Digestive Endoscopy and Clinical Research

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 723

Special Issue Editors

Dr. Manuele Furnari

E-Mail Website
Guest Editor
Gastroenterology Unit, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Martino, University of Genoa, Viale Benedetto XV, 16132 Genoa, Italy
Interests: gastroenterology; digestive endoscopy; hepatology
Dr. Stefano Kayali

E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Parma, Parma, Italy
Interests: gastroenterology; digestive endoscopy; hepatology

Special Issue Information

Dear Colleagues,

The role of digestive endoscopy in modern gastroenterology continues to expand, driving innovation in both diagnostics and therapeutics. Recent advancements in endoscopic technologies have revolutionized the diagnosis and management of gastrointestinal disorders, offering minimally invasive approaches that improve patient outcomes. From high-definition imaging and artificial intelligence-aided diagnostics to cutting-edge therapeutic procedures, digestive endoscopy serves as a bridge between clinical practice and translational research.

This Special Issue aims at exploring the transformative potential of digestive endoscopy in addressing unmet clinical needs and shaping the future of gastroenterology. Topics of focus include digestive endoscopy’s pivotal role in the treatment of early neoplastic lesions, advancements in diagnostic and interventional endoscopic ultrasound, applications in pancreatic and biliary diseases, contributions to small bowel pathology, the diagnostic and therapeutic management of inflammatory bowel diseases, and its impact on digestive pathophysiology.

We invite researchers and clinicians to contribute studies that highlight technological innovations and interdisciplinary applications within the field of gastrointestinal care.

We warmly welcome original research articles, comprehensive reviews, and expert opinions that demonstrate how digestive endoscopy is reshaping gastroenterology and advancing global health.

Dr. Manuele Furnari
Dr. Stefano Kayali
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digestive endoscopy
  • gastrointestinal disorders
  • endoscopic ultrasound (EUS)
  • endoscopic retrograde cholangiopancreatography (ERCP)
  • therapeutic endoscopy
  • artificial intelligence
  • pancreatic and biliary diseases
  • small bowel pathology
  • early neoplastic lesions
  • inflammatory bowel diseases (IBDs)
  • translational gastroenterology
  • endoscopic submucosal dissection (ESD)
  • per-oral endoscopic myotomy (POEM)
  • endoscopic imaging
  • gastrointestinal pathophysiology

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Published Papers (1 paper)

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Research

13 pages, 578 KB  
Article
Stress, Diet, and Sleep Shape Irritable-Bowel-Syndrome-Specific Symptoms: The Lockdown “Cocoon Effect”
by Stefano Kayali, Elisa Marabotto, Giorgia Bodini, Simona Marenco, Sara Labanca, Giulia Pieri, Patrizia Zentilin, Edoardo Giovanni Giannini and Manuele Furnari
J. Clin. Med. 2025, 14(23), 8487; https://doi.org/10.3390/jcm14238487 - 29 Nov 2025
Viewed by 302
Abstract
Background/Objectives: Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder affecting almost 10% of the general population, characterized by recurrent abdominal pain and altered bowel habits. Its pathophysiology is incompletely understood, but it is established that symptoms result from an interplay [...] Read more.
Background/Objectives: Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder affecting almost 10% of the general population, characterized by recurrent abdominal pain and altered bowel habits. Its pathophysiology is incompletely understood, but it is established that symptoms result from an interplay between several environmental- and patient-related factors. This study aimed to analyze the influence of a widespread shift in lifestyle habits and multidimensional stress on IBS manifestations. Methods: An online survey was administered during the COVID-19 lockdown in 2020 to three groups of people representative of the general population. The survey contained questions regarding socio-demographic data, dietary habits, alcohol, smoking, physical activity, sleeping, working activities, stress level, and the characteristics of gastrointestinal symptoms related to both the pre-pandemic period and the lockdown period. The definition of IBS was based on the Rome IV criteria. Multivariate analyses were used to evaluate the association between environmental variables and the occurrence/resolution of IBS. Results: A total of 2735 participants were enrolled. Among them, 122 patients (46.2%) reported symptoms’ improvement during the observation period, while 118 previously healthy subjects (4.8%) developed IBS symptoms. Reduced general stress (OR = 2.2, 95%CI 1.1–4.6, p = 0.029), increased fiber intake (OR = 2.8, 95%CI 1.6–5.0, p < 0.001), and increased hours of sleep (OR = 2.0, 95%CI 1.1–3.8, p = 0.031) were associated with a high probability of IBS resolution, while increased anxiolytic pill intake (OR = 0.14, 95%CI 0.04–0.46, p = 0.001) showed a low likelihood of IBS resolution. Reduced physical activity (OR = 2.0, 95%CI 1.3–3.2, p = 0.002), increased anti-inflammatory effects (OR = 2.4, 95%CI 1.4–4.1, p = 0.002), anxiolytic pill intake (OR = 3.5, 95%CI 2.1–5.9, p < 0.001), and increased work-related stress (OR = 1.8, 95%CI 1.2–2.8, p = 0.009) were risk factors for IBS symptoms’ occurrence. Reduced alcohol consumption was a protective factor (OR = 0.5, 95%CI 0.3–0.8, p = 0.006). The resolution of IBS did not affect upper gastrointestinal functional symptoms (OR = 0.2, 95%CI 0.1–0.3, p < 0.001). Conclusions: The widespread lifestyle change forced by the pandemic created a protective “Cocoon Effect”, resulting in a beneficial effect in almost half of patients with IBS. Our findings provide large-scale evidence that environmental factors play a pivotal role in the pathophysiology of IBS. Specifically, stress levels, fiber intake, sleep patterns, and alcohol consumption are key modifiable drivers of symptom occurrence and resolution. Full article
(This article belongs to the Special Issue Shaping Modern Gastroenterology: Bridging Advancements in Digestive Endoscopy and Clinical Research)
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