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Clinical Advances in Maternal–Fetal Medicine: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (20 March 2026) | Viewed by 665

Special Issue Editor


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Guest Editor
Department of Woman’s and Child’s Health, University of Padova, Padova, Italy
Interests: fetus; maternal fetal medicine; doppler; cardiovascular diseases; endometrosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “Clinical Advances in Maternal–Fetal Medicine: 2nd Edition”, a new volume following the successful publication of five papers in the first edition. For more details, please visit the following page: https://www.mdpi.com/journal/jcm/special_issues/H313XY40U0

Since the 1970s, maternal and fetal medicine (as a branch of obstetrics and gynecology) has been revolutionized.

Research is essential in cases of high-risk pregnancies and extends beyond clinical aspects to include biochemical markers, precision medicine, and more recently, artificial intelligence and its applications in understanding various diseases.

Therefore, this Special Issue encourages scientists to publish papers concerning all aspects of maternal and fetal medicine.

Dr. Erich Cosmi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision medicine
  • omics
  • clinical
  • fetus
  • Doppler

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Related Special Issue

Published Papers (1 paper)

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Review

12 pages, 469 KB  
Review
Celocentesis: Current Evidence and Future Directions
by Fabiana Cecchini, Silvia Visentin, Antonino Giambona, Margherita Vinciguerra, Francesco Picciotto, Alessandra Andrisani, Matteo Cassina, Ambrogio Pietro Londero, Kypros Nicolaides and Erich Cosmi
J. Clin. Med. 2026, 15(6), 2196; https://doi.org/10.3390/jcm15062196 - 13 Mar 2026
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Abstract
Background/Objectives: This study aimed to review current evidence on celocentesis as an early invasive prenatal diagnostic technique, focusing on its clinical applications, diagnostic accuracy, safety profile, and future perspectives in modern fetal medicine. Methods: A narrative review of the literature was conducted through [...] Read more.
Background/Objectives: This study aimed to review current evidence on celocentesis as an early invasive prenatal diagnostic technique, focusing on its clinical applications, diagnostic accuracy, safety profile, and future perspectives in modern fetal medicine. Methods: A narrative review of the literature was conducted through PubMed and Scopus databases up to October 2025. Studies reporting original data on celocentesis—including prospective studies, case reports, and case series—were included. Relevant outcomes were feasibility, safety, and diagnostic accuracy. Results: Since its first description in 1993, celocentesis has been successfully performed between 6 and 9 weeks’ gestation in several small case series. Improvements in ultrasound resolution and molecular analysis techniques have significantly enhanced its reliability. In specialized centers using dedicated fetal cell selection and contamination-control workflows, analytical diagnostic success for selected monogenic conditions exceeds 99%. Reported miscarriage rates are comparable to what is expected at a very early gestational age (10% of all clinically recognized pregnancies). The procedure remains mainly experimental, with no standardized protocols or large multicentric validation. Conclusions: Celocentesis is the earliest available technique for prenatal genetic diagnosis. While promising, its clinical implementation requires further standardization, comprehensive operator training, and robust evidence from prospective studies regarding its safety and diagnostic reliability. Full article
(This article belongs to the Special Issue Clinical Advances in Maternal–Fetal Medicine: 2nd Edition)
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