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Clinical Updates in Transfusion Medicine and Patient Blood Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: closed (20 May 2026) | Viewed by 935

Special Issue Editors


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Guest Editor
Department of Medicine, Complex Hospitalari Universitari Moisès Brogg, Consorci Sanitari Integral, 08970 Sant Joan Despi, Barcelona, Spain
Interests: anaemia; iron deficiency; intravenous iron; blood transfusion; patient blood management

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Guest Editor
Blood and Tissue Bank of Navarra, Servicio Navarro de Salud, Osasunbidea, 31008 Pamplona, Spain
Interests: anaemia; blood transfusion; hemovigilance, blood components; patient blood management
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Special Issue Information

Dear Colleagues,

Over the last two decades, we have seen an increasing implementation of patient blood management (PBM) programs, endorsed by multiple major healthcare institutions and organizations such as the World Health Organization (WHO). These PBM programs include a set of clinical practice strategies based on the concept of three main pillars: optimizing the patient’s own blood volume, minimizing blood loss, and improving the patient’s physiological tolerance for anemia, thereby avoiding unnecessary blood transfusions. Their implementation has led to a paradigm shift in the use of blood components, with a patient-centered approach designed to improve health outcomes through the improvement and care of their own blood.

For this Special Issue, we invite the submission of original research or review articles addressing various aspects of PBM. Authors are encouraged to contribute articles that evaluate the outcomes or benefits of implementing PBM programs as a whole, or some of their components specifically, in the routine scenario of perisurgical patients, in other scenarios such as in medical patients or obstetric patients, or in individuals of different age groups or with different associated characteristics. Likewise, we invite proposals related to transfusion medicine, both in terms of the evolution of its use and the evaluation of its adverse effects and hemovigilance.

We are looking forward to receiving your contributions.

Dr. Carlos Jerico
Dr. José Antonio García-Erce
Guest Editors

Manuscript Submission Information

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Keywords

  • anaemia
  • bleeding
  • blood transfusion
  • patient blood management
  • transfusion medicine

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Published Papers (1 paper)

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Review

21 pages, 1270 KB  
Review
Iron Deficiency and Oral Treatments: Limitations, Pharmacokinetics, and the Role of Iron Protein Succinylate in Clinical Practice
by José Antonio García-Erce, Santiago García-López and Antonio Martínez-Francés
J. Clin. Med. 2026, 15(10), 3691; https://doi.org/10.3390/jcm15103691 - 11 May 2026
Viewed by 400
Abstract
Iron deficiency (ID) is the most prevalent nutritional disorder worldwide, affecting diverse populations including children, women of reproductive age, older adults and patients with chronic conditions. Oral iron supplementation remains the cornerstone of treatment, together with management of the underlying causes. However, conventional [...] Read more.
Iron deficiency (ID) is the most prevalent nutritional disorder worldwide, affecting diverse populations including children, women of reproductive age, older adults and patients with chronic conditions. Oral iron supplementation remains the cornerstone of treatment, together with management of the underlying causes. However, conventional ferrous and ferric salts are often associated with gastrointestinal side effects, poor adherence and limited efficacy, especially in inflammatory settings due to hepcidin-mediated absorption blockade. This review summarizes iron absorption physiology, limitations of traditional oral therapies, and the potential benefits of iron protein succinylate (IPS), a ferric complex bound to succinylated casein. IPS provides pH-dependent release and contains succinic acid, which may enhance absorption while reducing gastrointestinal adverse events. Clinical studies indicate that IPS achieves hematologic outcomes comparable or superior to standard oral salts, fewer gastrointestinal effects and better tolerability. These properties make IPS suitable for patients who do not tolerate or respond adequately to conventional therapy. Special attention is given to chronic inflammation, pregnancy, cancer, or gastrointestinal disorders, where oral iron often fails due to impaired absorption or poorer tolerance. Practical recommendations are included to optimize supplementation through dosing strategies and tailored approaches. Overall, IPS offers an effective, better-tolerated alternative to conventional oral iron therapy. Full article
(This article belongs to the Special Issue Clinical Updates in Transfusion Medicine and Patient Blood Management)
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