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Clinical Advances in Cartilage Repair and Regeneration
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Clinical Advances in Cartilage Repair and Regeneration

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 1 October 2025 | Viewed by 813

Special Issue Editors

Dr. Akira Tsujii

E-Mail Website
Guest Editor
Department of Medical Sports Biomechanics, Graduate School of Medicine, The University of Osaka, Osaka, Japan
Interests: sports injury; meniscal and cartilage injury; aging-related changes in knee structures
Dr. Kazunori Shimomura

E-Mail Website
Guest Editor
Department of Rehabilitation, Kansai University of Welfare Sciences, Osaka, Japan
Interests: cartilage and meniscus repair; osteoarthritis; sports injuries; knee

Special Issue Information

Dear Colleagues,

Articular cartilage injury causes pain, joint swelling, and associated loss of joint function, which interfere with activities of daily living. However, cartilage has limited healing capacity, and it is impossible to stop the progression of cartilage injury over time. Consequently, many years have been spent on basic research using cells and animals to determine the optimal treatment for cartilage injury. Now, there are an increasing number of reports where novel approaches are being used in clinical practice. Various studies are being conducted to achieve healing and regeneration of cartilage in a state close to the normal structure, which has been difficult to achieve with conventional methods. In this Special Issue, we focus on ‘Cartilage Repair and Regeneration’ and discuss how various methods can be applied to cartilage injuries and what new methods have been proposed. We aim to provide readers with a broad and comprehensive overview of the results of clinical trials and long-term clinical outcomes.

Dr. Akira Tsujii
Dr. Kazunori Shimomura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cartilage
  • regenerative therapy
  • stem cell therapy
  • scaffold
  • orthobiologics
  • osteoarthritis

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Published Papers (1 paper)

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Research

17 pages, 1048 KiB  
Article
Comparison of Three Different Techniques for the Treatment of Cartilage Lesions—Matrix-Induced Autologous Chondrocyte Implantation (MACI) Versus Autologous Matrix-Induced Chondrogenesis (AMIC) and Arthroscopic Minced Cartilage—A 2-Year Follow-Up on Patient-Reported Pain and Functional Outcomes
by Stefan Schneider, Dagmar Linnhoff, Ansgar Ilg, Gian M. Salzmann, Robert Ossendorff and Johannes Holz
J. Clin. Med. 2025, 14(7), 2194; https://doi.org/10.3390/jcm14072194 - 23 Mar 2025
Viewed by 446
Abstract
Background/Objectives: The treatment of cartilage damage is an ongoing challenge. Several techniques have been developed to address this problem. Matrix-Induced Autologous Chondrocyte Implantation (MACI) is often referred to as the “gold standard” for cartilage treatment. Numerous long-term outcome studies also have reported [...] Read more.
Background/Objectives: The treatment of cartilage damage is an ongoing challenge. Several techniques have been developed to address this problem. Matrix-Induced Autologous Chondrocyte Implantation (MACI) is often referred to as the “gold standard” for cartilage treatment. Numerous long-term outcome studies also have reported favorable results with Autologous Matrix-Induced Chondrogenesis (AMIC). Minced Cartilage Implantation (MCI) is a recently developed arthroscopic method. This technique has demonstrated promising outcomes, with the prospect of longer-term results still under investigation. This study aims to directly compare the patient-reported outcomes of these three techniques over a 2-year follow-up period. Methods: A total of N = 48 patients were included in the retrospective matched pair analysis (n = 16 MACI, n = 16 AMIC, n = 16 MCI). VAS, KOOS-Pain, and KOOS-Symptoms scores served as primary outcomes; the KOOS-ADL and -QOL and the Tegner Activity Scale (TAS) served as secondary outcomes. Results: All three groups did not differ from each other in the primary or secondary outcomes. Pain and function significantly improved from pre-surgery to two years after (VAS: p < 0.000; ES: η2 = 0.27; KOOS-Pain: p < 0.000; ES: η2 = 0.30; KOOS-Symptoms: p = 0.000; ES: η2 = 0.26; KOOS-ADL: p > 0.000; ES: η2 = 0.20; KOOS-QOL: p > 0.000; ES: η2 = 0.30). There was no significant effect of time on the activity level. Conclusions: All three procedures show good patient-reported outcomes, low complication rates, and long graft longevity in the 2-year follow-up. Therefore, all three methods seem to be equally recommendable for the treatment of cartilage lesions. Full article
(This article belongs to the Special Issue Clinical Advances in Cartilage Repair and Regeneration)
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