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Clinical Medicine and Surgery in the Digital Age: Advances in...
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Clinical Medicine and Surgery in the Digital Age: Advances in Virtual, Augmented, Mixed, and Extended Reality

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 533

Special Issue Editors

Dr. Mohsen Annabestani

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Guest Editor
Dalio Institute of Cardiovascular Imaging, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA
Interests: robotics; biomedical engineering; AI and machine learning; image and signal processing; AR/XR
Dr. Bobak Mosadegh

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Guest Editor
Biomedical Engineering in Radiology, Dalio Institute of Cardiovascular Imaging, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA
Interests: cardiac imaging; medical devices; robotics; deep learning; AR/XR

Special Issue Information

Dear Colleagues,

The integration of Virtual Reality (VR), Augmented Reality (AR), Mixed Reality (MR), and Extended Reality (XR) technologies into clinical medicine and surgery marks a significant leap forward in medical practice, revolutionizing the way healthcare is delivered and experienced. These cutting-edge technologies offer unprecedented opportunities for enhancing diagnostic accuracy, improving surgical outcomes and personalizing patient care. This Special Issue aims to explore the transformative impact of these technologies on clinical procedures, medical training, patient care, and surgical precision. Despite substantial progress, the field faces core challenges such as the need for standardized protocols, a validation of clinical outcomes, an integration with medical devices, and ensuring patient safety during the implementation of these advanced technologies.

The scope of this Special Issue encompasses a broad range of topics, including but not limited to, the development and application of VR, AR, MR, and XR in surgical training, real-time catheterization, rehabilitation, telemedicine, and patient education. We seek original research, comprehensive reviews, and insightful case studies that address current research status, highlight significant breakthroughs, and propose innovative solutions to the existing challenges.

We invite researchers, clinicians, and technologists to contribute their work and collaborate in advancing the frontiers of clinical medicine and surgery through immersive technologies. By sharing knowledge and innovative practices, we aim to foster a collaborative environment that drives the integration of digital innovations into everyday medical practice, ultimately improving patient outcomes and healthcare efficiency.

Dr. Mohsen Annabestani
Dr. Bobak Mosadegh
Guest Editors

Prof. Alexandros Sigaras
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • virtual reality (VR)
  • augmented reality (AR)
  • mixed reality (MR)
  • extended reality (XR)
  • clinical medicine
  • surgery
  • diagnostic accuracy
  • surgical outcome
  • patient care
  • medical training

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Published Papers (1 paper)

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14 pages, 4053 KiB  
Case Report
Virtual Reality for Pre-Procedural Planning of Interventional Pain Procedures: A Real-World Application Case Series
by Ingharan J. Siddarthan, Cary Huang, Parhesh Kumar, John E. Rubin, Robert S. White, Neel Mehta and Rohan Jotwani
J. Clin. Med. 2025, 14(9), 3019; https://doi.org/10.3390/jcm14093019 - 27 Apr 2025
Viewed by 233
Abstract
Background/Objectives: Virtual reality (VR), a component of extended reality (XR), has shown promise in pre-procedural planning by providing immersive, patient-specific simulations. In pain management, where precise anatomical understanding is critical for interventions such as peripheral nerve stimulation (PNS), nerve blocks, and intrathecal [...] Read more.
Background/Objectives: Virtual reality (VR), a component of extended reality (XR), has shown promise in pre-procedural planning by providing immersive, patient-specific simulations. In pain management, where precise anatomical understanding is critical for interventions such as peripheral nerve stimulation (PNS), nerve blocks, and intrathecal pump placement, the application of VR remains underexplored. This case series examines the role of VR in enhancing pre-procedural planning for complex chronic pain interventions. Methods: From August 2022 to December 2024, six patients with anatomically challenging conditions underwent VR-assisted pre-procedural planning at Weill Cornell Medical Center. Patient-specific 3D models were created using the manual or automatic segmentation of imaging data and reviewed in VR to optimize procedural strategies by the surgeons performing the case. Procedures were then performed using conventional fluoroscopic or ultrasound guidance. Results: In all cases, VR facilitated the improved visualization of complex anatomies and informed optimal procedural trajectories. In patients with a complex cancer anatomy, previous surgical changes, or hardware, VR enabled precise PNS lead or needle placement, resulting in significant pain reductions postoperatively. In certain cases where previous interventional pain procedures had failed, VR allowed for a “second opinion” to develop an alternative approach with improved outcomes. Finally, in one case, VR served to potentially prevent patient harm by providing insight to the proceduralists regarding an alternative approach. Across the series, VR enhanced the spatial awareness, procedural accuracy, and confidence in navigating challenging anatomical scenarios. Conclusions: This case series demonstrates the utility of VR in pre-procedural planning for chronic pain interventions. By enabling detailed anatomical visualization and trajectory optimization, VR has the potential to improve outcomes in complex cases. Further studies are needed to evaluate its broader clinical applications and cost-effectiveness in pain management. Full article
(This article belongs to the Special Issue Clinical Medicine and Surgery in the Digital Age: Advances in Virtual, Augmented, Mixed, and Extended Reality)
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