Updates on Current Therapies for Esophagus and Esophageal Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 673

Special Issue Editors


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Guest Editor
Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy
Interests: esophageal cancer; gastric cancer; surgical oncology

E-Mail Website
Guest Editor
Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy
Interests: esophageal cancer; gastric cancer; surgical oncology

E-Mail
Guest Editor
Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy
Interests: esophageal cancer; gastric cancer; surgical oncology

Special Issue Information

Dear Colleagues,

Characterized by its aggressive nature, high morbidity and mortality rates, esophageal cancer represents a global health burden. Aiming to enhance early detection, refine diagnostic approaches, and develop more effective treatment strategies, extensive research efforts have been dedicated to unraveling the intricate complexities of this disease.

As a result, personalized treatment with targeted therapies, immunotherapies, and combination treatment regimens have emerged as promising avenues for combating esophageal cancer while minimizing adverse effects.

While surgical intervention remains a mainstay in the management of esophageal cancer, researchers have been actively exploring minimally invasive and organ-preserving approaches to reduce invasiveness, encourage faster recovery, and improve quality of life for patients.

The challenges posed by advanced and metastatic esophageal cancer necessitate a concerted effort to develop more effective systemic therapies.

Addressing the holistic needs of patients with cancer is a matter of paramount importance. The management of treatment-related side-effects, nutritional support, psychosocial care, and survivorship issues are essential components of comprehensive patient care.

Research submitted to this Issue should aim to enhance patient well-being, optimize treatment adherence, and foster improved quality of life throughout the cancer journey.

We extend our deepest gratitude to the authors for their exceptional contributions and hope that this Special Issue will serve as a catalyst for further progress in the treatment of esophageal cancer.

Dr. Elisa Sefora Pierobon
Dr. Lucia Moletta
Dr. Giovanni Capovilla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esophageal cancer
  • adenocarcinoma
  • squamous cell carcinoma
  • molecular profiling
  • personalized treatment
  • surgical innovation
  • supportive care
  • quality of life
  • survivorship

Published Papers (1 paper)

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Research

13 pages, 2054 KiB  
Article
Short- and Long-Term Outcomes in Elderly Patients with Resectable Esophageal Cancer: Upfront Esophagectomy Compared to Surgery after Neoadjuvant Treatments
by Lucia Moletta, Elisa Sefora Pierobon, Giovanni Capovilla, Irene Sole Zuin, Jose Luis Carrillo Lizarazo, Giulia Nezi, Sara Lonardi, Sabina Murgioni, Sara Galuppo, Gianpietro Zanchettin, Renato Salvador, Luca Provenzano and Michele Valmasoni
J. Clin. Med. 2024, 13(14), 4271; https://doi.org/10.3390/jcm13144271 - 22 Jul 2024
Viewed by 387
Abstract
Background/Objectives: Despite the increased incidence of esophageal cancer (EC) in elderly people, there are no clear guidelines for its treatment in these patients. The aim of this study was to compare the outcomes of patients ≥ 75 years with resectable EC, receiving either [...] Read more.
Background/Objectives: Despite the increased incidence of esophageal cancer (EC) in elderly people, there are no clear guidelines for its treatment in these patients. The aim of this study was to compare the outcomes of patients ≥ 75 years with resectable EC, receiving either upfront esophagectomy or neoadjuvant treatment. Methods: We retrospectively identified 127 patients with resectable EC ≥ 75 years who underwent esophagectomy between January 2000 and December 2022 at our Clinic in the University Hospital of Padova. The included patients were stratified into two groups: patients undergoing upfront esophagectomy (SURG group) and patients receiving neoadjuvant treatment (NAT group). Results: There were no statistically significant differences in OS (p = 0.7708), DFS (p = 0.7827) and cancer-related survival (p = 0.0827) between the SURG and the NAT group, except for the OS of EAC with stage III-IV, where the NAT group experienced a significant benefit in OS (p = 0.0263). When comparing the two groups, patients receiving neoadjuvant treatment experienced a significantly higher rate of postoperative complications (p = 0.0266). At univariate analysis, neoadjuvant therapy was the only variable strongly associated with postoperative morbidity (p = 0.026). Conclusions: Considering the unique characteristics of elderly patients, the choice of a multimodal approach should be tailored to each case in a multidisciplinary setting and balanced with a potential higher risk of postoperative complications, as well as potential toxicity related to chemoradiation and reduced life expectancy. Full article
(This article belongs to the Special Issue Updates on Current Therapies for Esophagus and Esophageal Cancer)
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