Clinical Perspectives on Adenomyosis- and Endometriosis-Associated Infertility

Dear Colleagues,

Endometriosis and adenomyosis are common benign gynecological disorders that affect reproductive-aged women. Both conditions share a histologic pattern, displaying the presence of ectopic endometrial tissue in unusual locations, and are associated with adverse reproductive outcomes. The heterogeneity of endometriosis and adenomyosis, as well as their frequent coexistence, contribute to the variability in available evidence. Proposed reasons for its association with adverse reproductive outcomes include disrupted pelvic anatomy, chronic pelvic inflammation, and reduced ovarian reserves for endometriosis, while uterine inflammation, abnormal contractility, and abnormal endothelial function are suggested to be causes of adenomyosis. Despite numerous studies being published in recent years, effective treatment strategies in infertile women with these conditions are still unclear, posing a common challenge during counseling of this population.

For this Special Issue, we invite our colleagues to submit work focused on relevant topics, such as the role of surgery in infertility based on different subtypes of endometriosis and adenomyosis, the hormonal pretreatment in assisted reproductive technology, fertility preservation, and other coexistent clinical entities associated with endometriosis and adenomyosis.

Dr. Dimitrios Rafail Kalaitzopoulos
Prof. Dr. Angelos Daniilidis
Guest Editors

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