Clinical Perspectives on Adenomyosis- and Endometriosis-Associated Infertility

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1093

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, Cantonal Hospital of Schaffhausen, 8208 Schaffhausen, Switzerland
Interests: endometriosis; adenomyosis; infertility

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Guest Editor
1st Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece
Interests: reproductive surgery; endometriosis

Special Issue Information

Dear Colleagues,

Endometriosis and adenomyosis are common benign gynecological disorders that affect reproductive-aged women. Both conditions share a histologic pattern, displaying the presence of ectopic endometrial tissue in unusual locations, and are associated with adverse reproductive outcomes. The heterogeneity of endometriosis and adenomyosis, as well as their frequent coexistence, contribute to the variability in available evidence. Proposed reasons for its association with adverse reproductive outcomes include disrupted pelvic anatomy, chronic pelvic inflammation, and reduced ovarian reserves for endometriosis, while uterine inflammation, abnormal contractility, and abnormal endothelial function are suggested to be causes of adenomyosis. Despite numerous studies being published in recent years, effective treatment strategies in infertile women with these conditions are still unclear, posing a common challenge during counseling of this population.

For this Special Issue, we invite our colleagues to submit work focused on relevant topics, such as the role of surgery in infertility based on different subtypes of endometriosis and adenomyosis, the hormonal pretreatment in assisted reproductive technology, fertility preservation, and other coexistent clinical entities associated with endometriosis and adenomyosis.

Dr. Dimitrios Rafail Kalaitzopoulos
Prof. Dr. Angelos Daniilidis
Guest Editors

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Keywords

  • endometriosis
  • adenomyosis
  • infertility
  • assisted reproductive technology
  • IVF
  • laparoscopy
  • hormonal therapy
  • reproductive outcomes

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Published Papers (1 paper)

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Review

13 pages, 276 KiB  
Review
The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis
by Georgios Grigoriadis, Horace Roman, Fani Gkrozou and Angelos Daniilidis
J. Clin. Med. 2024, 13(16), 4817; https://doi.org/10.3390/jcm13164817 - 15 Aug 2024
Viewed by 593
Abstract
Minimal/mild endometriosis (MME) is independently associated with reduced fecundity rates. In this review article, we discuss the role of laparoscopic surgery in enhancing the fertility outcomes of patients with MME. Laparoscopic management of MME enhances fecundity and increases the chances of spontaneous conception [...] Read more.
Minimal/mild endometriosis (MME) is independently associated with reduced fecundity rates. In this review article, we discuss the role of laparoscopic surgery in enhancing the fertility outcomes of patients with MME. Laparoscopic management of MME enhances fecundity and increases the chances of spontaneous conception in appropriately selected cases. However, laparoscopy cannot be routinely recommended in asymptomatic patients with the sole purpose of diagnosing and treating potentially present MME. Equally, and based on existing information, the laparoscopic management of MME cannot be routinely recommended prior to in vitro fertilisation (IVF) attempts due to the lack of robust and beneficial evidence. Because an overlap between unexplained infertility and MME cases likely exists, the development of reliable, widely available, non-invasive tests for the diagnosis of MME may revolutionise the management of cases currently classified as unexplained infertility. In a disease as diverse as endometriosis, management decisions should be based on a multitude of factors. Future studies should focus on reporting the outcomes of interventions for MME on fertility and obstetric outcomes, clearly differentiating between disease stages and phenotypes. Full article
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