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Advances in the Prevention and Treatment of Cardiovascular Diseases: What...
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Advances in the Prevention and Treatment of Cardiovascular Diseases: What We Addressed and What We Still Need to Address

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: 30 June 2026 | Viewed by 521

Special Issue Editors

Dr. Alessandro Durante

E-Mail Website
Guest Editor
Interventional and Clinical Cardiology Unit, Policlinico San Marco, 24040 Zingonia, Italy
Interests: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandro Mazzapicchi

E-Mail Website
Guest Editor Assistant
Interventional and Clinical Cardiology Unit, Policlinico San Marco, 24040 Zingonia, Italy
Interests: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia

Special Issue Information

Dear Colleagues,

In recent years, many pharmacological and interventional treatments have been introduced to treat various cardiovascular diseases (CVDs). The prognosis of each individual disease has been improved. However, cardiovascular diseases still remain the first cause of death in developed countries. Thus, there are still many needs to be addressed. Might prevention be the future most important area of reserch for this spectrum of disease?

The aim of this Special Issue is to collect submissions focusing on the latest advances in the prevention and treatment of cardiovascular diseases. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

Advanced treatment, including pharmacological and non-pharmacological interventions.
The use of new technologies in diagnosis and management.
The role of lifestyle modifications in prevention and treatment.
The impact of comorbidities on prevention and treatment.
The challenges and future directions in prevention and treatment .
Coronary artery disease.
Coronary angiography.
Percutaneous coronary intervention.
Percutaneous structural intervention.
Left atrial appendage closure.
Transcatheter aortic valve implantation (TAVI).

Dr. Alessandro Durante
Guest Editor

Dr. Alessandro Mazzapicchi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

10 pages, 779 KB  
Article
Coronary Artery Calcification on Non-Cardiac Gated CT Thorax Scans: A Single Tertiary Centre Retrospective Observational Study
by Robert S. Doyle, Divyanshu Jain, Patrick Devitt, Jack Hartnett, Hugo C. Temperley and Catherine McGorrian
J. Cardiovasc. Dev. Dis. 2025, 12(12), 480; https://doi.org/10.3390/jcdd12120480 - 4 Dec 2025
Viewed by 274
Abstract
Background: While the 2024 ESC Guidelines provide guidance on utilising incidental CAC findings from non-gated CT scans to enhance risk stratification and guide treatment decisions, there remain gaps in detailed protocols for managing such incidental findings, particularly in inpatient settings. An incidental finding [...] Read more.
Background: While the 2024 ESC Guidelines provide guidance on utilising incidental CAC findings from non-gated CT scans to enhance risk stratification and guide treatment decisions, there remain gaps in detailed protocols for managing such incidental findings, particularly in inpatient settings. An incidental finding of CAC in a patient without known atherosclerosis provides an opportunity to assess cardiac risk, promote risk factor optimisation and evaluate need for further cardiac work up. The aim of this study was to assess the prevalence of incidental coronary artery calcification on non-cardiac dedicated gated CT thorax scans among general medical inpatients and to evaluate the subsequent management of these findings. Methods: This was a single-centre retrospective observational study of consecutive general medical inpatients aged 40–75, who had undergone a non-cardiac gated CT thorax during their admission, between February and March 2025. Data were collected using local electronic health records. Exclusion criteria were patients with known ischaemic heart disease (IHD). Risk factor assessment was noted by documentation of smoking status, hypertension, diabetes and low-density lipoprotein (LDL) values. Results: A total of 186 patients with thoracic CT scans were identified. On review of all CT reports, 53 (28.4%) patients had CAC reported, of whom 17 had known IHD. Therefore 36 (19.4%) patients were identified for further analysis. An exercise stress test was booked in none of the patients. A coronary angiogram was booked in 1 patient. Conclusions: One fifth of medical inpatients in our study had a new finding of CAC on thoracic imaging. Cardiovascular risk factors of LDL and HbA1c were checked in less than half of patients. None of these patients went on to have functional testing. There is a valuable opportunity to optimise cardiac risk factors and evaluate the need for functional testing in a subset of patients with CAC reported on non-cardiac CTs. This can be facilitated by raising awareness and implementing a flowchart tool for hospital physicians to reference. Full article
(This article belongs to the Special Issue Advances in the Prevention and Treatment of Cardiovascular Diseases: What We Addressed and What We Still Need to Address)
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