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New Advances in Hip and Knee Arthroplasty

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 4573

Special Issue Editor


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Guest Editor
Arthroplasty Center, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7 Keunjaebong-gil, Hwaseong 445-170, Republic of Korea
Interests: hip arthroplasty; knee arthroplasty; joint replacement; revision surgery; orthopedic implants; robotic surgery

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue of the Journal of Clinical Medicine, titled “New Advances in Hip and Knee Arthroplasty.”

Total hip and knee arthroplasty are among the most frequently performed and highly effective orthopedic procedures worldwide. As the global population continues to age and the demand for joint replacement grows, advancements in surgical techniques, implant technology, and perioperative management are more important than ever.

This Special Issue aims to highlight recent innovations, clinical outcomes, and evidence-based practices in hip and knee arthroplasty. In alignment with the Journal of Clinical Medicine's scope, we welcome submissions that explore robotic-assisted surgery, perioperative care, management of complications, and strategies for revision arthroplasty. Both original research articles and comprehensive reviews will be considered.

This Special Issue welcomes original research articles and reviews. Research areas may include (but are not limited to) the following:

  • Robotics and computer-assisted surgery;
  • Perioperative optimization and enhanced recovery;
  • Infection prevention and revision strategies;
  • Functional outcomes and patient satisfaction;
  • Long-term implant survival.

We look forward to receiving your contributions.

Prof. Dr. Jun-Dong Chang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hip arthroplasty
  • knee arthroplasty
  • joint replacement
  • revision surgery
  • orthopedic implants
  • robotic surgery
  • peri-operative care
  • functional outcomes
  • complication management
  • orthopedic innovation

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Published Papers (7 papers)

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Research

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14 pages, 1770 KB  
Article
Clinical Outcomes of Partial Two-Stage Revision with Femoral Stem Retention in Elderly Patients with Hip Periprosthetic Joint Infection
by Ji Hoon Bahk, Jun-Dong Chang, Young Wook Lim, Sinje Kim and Kee-Haeng Lee
J. Clin. Med. 2026, 15(6), 2102; https://doi.org/10.3390/jcm15062102 - 10 Mar 2026
Viewed by 356
Abstract
Background/Objectives: Periprosthetic joint infection (PJI) of the hip remains a challenging complication, particularly in elderly patients who may not tolerate repeated invasive procedures. While two-stage, one-stage, and 1.5-stage revisions are established strategies, an optimal approach for elderly patients with a well-fixed femoral [...] Read more.
Background/Objectives: Periprosthetic joint infection (PJI) of the hip remains a challenging complication, particularly in elderly patients who may not tolerate repeated invasive procedures. While two-stage, one-stage, and 1.5-stage revisions are established strategies, an optimal approach for elderly patients with a well-fixed femoral stem remains unclear. This study evaluated the clinical outcomes of partial two-stage revision with femoral stem retention in elderly patients with hip PJI. Methods: A retrospective review was conducted of patients aged 65 years or older who underwent two-stage revision for hip PJI without femoral stem extraction at a single institution and had a minimum follow-up of one year after the final treatment. Patients were treated with aggressive debridement, removal of all components except the femoral stem, and placement of an antibiotic-loaded cement spacer and beads. Clinical outcomes, infection eradication, complications, and functional status were assessed. Results: Twenty-eight patients (28 hips) were included, with a mean age of 79.5 years and a mean follow-up of 46.2 months. The index arthroplasty was hemiarthroplasty in most cases (92.9%). Seventeen patients completed a second-stage revision, while 11 remained with cement spacer retention. Infection control was achieved in all patients (100%) at final follow-up, with initial infection control achieved in 96.4%. No recurrence of infection was observed in either group. Multidrug-resistant organisms were identified in 67.9% of cases. Functional outcomes were acceptable, and no stem-related complications or reinfections occurred. Conclusions: Partial two-stage revision with femoral stem retention provided effective infection control and acceptable functional outcomes in elderly patients with hip PJI. This approach may be considered a reasonable treatment option for elderly patients with a well-fixed femoral stem when reducing surgical invasiveness is an important consideration. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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10 pages, 336 KB  
Article
Metabolic Optimisation in Total Joint Arthroplasty: A Single-Centre Retrospective Cohort Pilot Study on the Safety and Feasibility of a Digitally Supported Perioperative Diet Modification
by Hwee Wen Ong, Khairul Anwar Ayob, David Siew-Kit Choon and Virginia Hartono
J. Clin. Med. 2026, 15(5), 1948; https://doi.org/10.3390/jcm15051948 - 4 Mar 2026
Viewed by 658
Abstract
Background/Objectives: Obesity and type 2 diabetes are increasingly common among patients undergoing hip and knee arthroplasty and are associated with higher risks of prosthetic joint infection, impaired wound healing, and prolonged hospitalisation. Dietary carbohydrate restriction has demonstrated benefits in glycemic control and [...] Read more.
Background/Objectives: Obesity and type 2 diabetes are increasingly common among patients undergoing hip and knee arthroplasty and are associated with higher risks of prosthetic joint infection, impaired wound healing, and prolonged hospitalisation. Dietary carbohydrate restriction has demonstrated benefits in glycemic control and weight reduction, but its feasibility and safety in the perioperative arthroplasty population remain underexplored. This pilot study evaluated the safety, feasibility, and short-term metabolic effects of a low-carbohydrate diet supported by WhatsApp-based meal photo-logging in patients undergoing total hip or knee arthroplasty. Methods: A retrospective cohort analysis was performed on 43 patients enrolled in a carbohydrate-restricted dietary programme between 2021 and 2024. Patients submitted photographs of all meals via WhatsApp with a minimum contact frequency of four times daily, enabling real-time feedback and medication adjustment. Anthropometric and metabolic parameters, including weight, BMI, HbA1c, renal function, and lipid profile, were assessed before and after the intervention. Results: Participants (mean age 69.12 ± 7.51 years) demonstrated significant improvement across several metabolic markers. Mean weight decreased by 5.74 kg (p < 0.001), BMI by 2.26 kg/m2 (p < 0.001), and HbA1c by 0.72% (p < 0.001). No episodes of severe hypoglycaemia or perioperative discharge delays related to glycemic instability were observed. Renal function remained stable, with no significant change in eGFR (p = 0.442). Among patients with available lipid data (n = 14), LDL-cholesterol and total cholesterol increased, while triglycerides showed a non-significant downward trend. Conclusions: A low-carbohydrate diet combined with high-frequency digital monitoring appears feasible and safe, achieving meaningful short-term improvements in weight and glycemic control without adverse renal or hypoglycemic events. The lipid changes observed, however, warrant cautious interpretation. These findings are hypothesis-generating, and larger prospective studies are needed to confirm the clinical impact of this approach and its relevance to perioperative optimisation. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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10 pages, 1014 KB  
Article
The Degree of Joint Line Obliquity Change Is Not Associated with Patient Preference in Bilateral Posterior-Stabilized Total Knee Arthroplasties
by Sang Jun Song, Young Kook Kim, Sae Heon Kim and Cheol Hee Park
J. Clin. Med. 2026, 15(5), 1889; https://doi.org/10.3390/jcm15051889 - 2 Mar 2026
Viewed by 361
Abstract
Objectives: To evaluate patient reference in paired bilateral posterior stabilized (PS) total knee arthroplasties (TKAs) with significantly different degrees of joint line obliquity (JLO) change. Methods: A retrospective review was conducted on 128 patients who underwent paired bilateral PS TKAs, with greater and [...] Read more.
Objectives: To evaluate patient reference in paired bilateral posterior stabilized (PS) total knee arthroplasties (TKAs) with significantly different degrees of joint line obliquity (JLO) change. Methods: A retrospective review was conducted on 128 patients who underwent paired bilateral PS TKAs, with greater and smaller JLO changes (G-ΔJLO and S-ΔJLO knees; a side-to-side difference in JLO change >3° between G-ΔJLO and S-ΔJLO knees). The mean follow-up period was 3.9 years (minimum 2 years). Radiographic changes in JLO were measured according to the Coronal Plane Alignment of the Knee (CPAK) classification. Maintenance of the CPAK type and JLO direction (apex distal, neutral, and apex proximal) was investigated. Clinically, the preferred TKA out of greater and smaller JLO changes was investigated. The Hospital for Special Surgery and Western Ontario and McMaster Universities Osteoarthritis Index were evaluated. Results: The average JLO change was 10.5° in the G-ΔJLO knees and 5.5° in the S-ΔJLO knees (p < 0.001). The CPAK type and JLO direction was better maintained in the S-ΔJLO knees (p < 0.001, respectively). Regarding preference, 40 patients (31.2%) were satisfied with bilateral TKAs without a specific preference, while 44 patients (34.3%) preferred TKAs of the G-ΔJLO knee and 44 patients (34.3%) preferred the S-ΔJLO knee (p = 1.000). No significant differences were found in the patient reported outcomes between the G- and S-ΔJLO knees. Conclusions: The degree of joint line obliquity change was not associated with patient preference in bilateral PS TKAs. JLO preservation may not be a critical determinant of patient preference in PS TKA. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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9 pages, 1748 KB  
Article
A Novel Potential Landmark for Intraoperative Estimation of Femoral Stem Anteversion: An Analysis of Computed Tomography Measurements
by Ho Hyun Yun, Woo Seung Lee, Young Bae Kim and Jun Woo Park
J. Clin. Med. 2026, 15(3), 945; https://doi.org/10.3390/jcm15030945 - 24 Jan 2026
Viewed by 409
Abstract
Background/Objectives: Femoral anteversion (FA) is the angle between the femoral neck axis (FNA) and the posterior condylar axis (PCA). Surgeons generally estimate intraoperative femoral stem anteversion visually relative to the PCA, but this method can be challenging even for experienced surgeons. This study [...] Read more.
Background/Objectives: Femoral anteversion (FA) is the angle between the femoral neck axis (FNA) and the posterior condylar axis (PCA). Surgeons generally estimate intraoperative femoral stem anteversion visually relative to the PCA, but this method can be challenging even for experienced surgeons. This study aimed to find an anatomical proximal landmark within a CT coordinate system for intraoperative estimation of femoral stem anteversion. Methods: Seventy patients were included. The anterior lesser trochanter line (ALTL) was defined as the line passing through two tangent points: one between the rounded part of the lesser trochanter and the medial edge of the anterior lesser trochanter cortex, and the other between the anterior cortex of the femur and the lateral edge of the anterior lesser trochanter cortex at the level of the lesser trochanter tip. The following angles were measured and analyzed: Angle 1 (angle between the FNA and the ALTL), Angle 2 (angle between the ALTL and the PCA), and Angle 3 (angle between the FNA and the PCA [FA]). Results: In all measurements, the inter-observer and intra-observer intraclass correlation coefficients exceeded 0.81. Angle 1 negatively correlated with Angle 2 (r = −0.79, p < 0.01), whereas Angle 1 positively correlated with Angle 3 (r = 0.70, p < 0.01). Conclusions: We found a consistent relationship between the ALTL and FA, and the ALTL may serve as a proximal landmark for intraoperative estimation of femoral stem anteversion during anterior or anterolateral approaches. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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12 pages, 706 KB  
Article
Comparison of Short-Term Outcomes and Survivorship of Three Modular Dual Mobility Implants in Primary Total Hip Surgery
by Mitchell Kennedy, Braden Terner, Chukwuweike Gwam and Ran Schwarzkopf
J. Clin. Med. 2025, 14(19), 6977; https://doi.org/10.3390/jcm14196977 - 1 Oct 2025
Viewed by 1609
Abstract
Background: Total hip arthroplasty (THA) is a common procedure, yet instability and dislocation remain leading causes of revision. Dual mobility (DM) acetabular constructs improve stability, but comparative data across modular DM systems are limited. This study compared the safety and efficacy of [...] Read more.
Background: Total hip arthroplasty (THA) is a common procedure, yet instability and dislocation remain leading causes of revision. Dual mobility (DM) acetabular constructs improve stability, but comparative data across modular DM systems are limited. This study compared the safety and efficacy of three modular DM implants in primary THA, focusing on acetabular revision and functional recovery. Methods: We retrospectively reviewed 963 primary THAs performed from 2016–2024 using three modular DM systems. Patients with revision or bilateral THA, age < 18, or <2 years of follow-up were excluded. Outcomes included acetabular revision, 90-day readmission, and Hip Disability and Osteoarthritis Outcome Score for Joint Replacement (HOOS, JR). Kaplan–Meier analysis estimated 3-year implant survivorship for each implant, and non-inferiority of Implant A was tested against a combined “Dual Mobility Control” cohort (Implants B + C) using a prespecified −10% margin. Results: A total of 297 patients met inclusion criteria (142 Implant A, 110 Implant B, 45 Implant C). Revision rates were 4.9% for Implant A, 6.4% for Implant B, and 8.9% for Implant C. HOOS, JR scores improved significantly in all cohorts with comparable 2-year outcomes. Kaplan–Meier analysis showed 3-year survivorship of 98.3% for Implant A, 98.4% for Implant B, and 96.9% for Implant C (log-rank p = 0.053). The Dual Mobility Control cohort survivorship was 98.0%, and the difference between Implant A and controls (95% CI: −2.19% to 2.69%) met the non-inferiority margin (log-rank p = 0.796). Conclusions: Implant A demonstrated non-inferior 3-year survivorship and comparable short-term patient-reported outcomes relative to two other modular DM implants. Larger, multicenter studies with longer follow-up are warranted to confirm these findings. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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Review

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21 pages, 784 KB  
Review
A Narrative Review of Spinopelvic Alignment Changes After Total Hip Arthroplasty
by Hiroyuki Ike, Hyonmin Choe, Naomi Kobayashi, Ken Kumagai and Yutaka Inaba
J. Clin. Med. 2026, 15(6), 2228; https://doi.org/10.3390/jcm15062228 - 15 Mar 2026
Viewed by 525
Abstract
Total hip arthroplasty (THA) reliably restores function, yet instability remains a clinically relevant complication. Increasing evidence indicates that postoperative stability is strongly influenced by the dynamic spine–pelvis–hip interaction, which modulates functional acetabular orientation across postures. This narrative review summarizes current evidence on postoperative [...] Read more.
Total hip arthroplasty (THA) reliably restores function, yet instability remains a clinically relevant complication. Increasing evidence indicates that postoperative stability is strongly influenced by the dynamic spine–pelvis–hip interaction, which modulates functional acetabular orientation across postures. This narrative review summarizes current evidence on postoperative spinopelvic alignment changes after THA with emphasis on temporal patterns, underlying mechanisms, and predictive factors. Early after THA, restoration of hip motion can partially normalize hip-driven compensatory patterns, however substantial interindividual variability persists. Mid- to long-term follow-up shows that pelvic orientation continues to evolve, particularly progressive posterior pelvic tilt in standing, largely driven by aging and spinal degeneration, with acceleration in older patients and those with spinal pathology. Prediction of postoperative pelvic behavior requires integrated assessment of pelvic orientation, spinal alignment and mobility, contralateral hip status, and whether imbalance is hip-driven versus spine-driven. Although classification- and model-based approaches can estimate postoperative pelvic tilt, clinically meaningful prediction uncertainty remains, supporting a strategy focused on risk stratification and adaptive preoperative planning. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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Other

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8 pages, 346 KB  
Brief Report
Preliminary Experience with New Dual-Mobility System for Small Japanese Patients
by Kenji Kawate, Tomohiro Teranishi, Yumiko Kondo, Mitsumasa Matsui and Shinji Ueno
J. Clin. Med. 2026, 15(9), 3525; https://doi.org/10.3390/jcm15093525 - 5 May 2026
Abstract
Background/Objectives: The preliminary experience with new dual-mobility system for small Japanese patients was introduced in this paper. Methods: Twenty-nine hips which underwent primary THA were retrospectively reviewed. All cups were inserted via Hardinge lateral approach. The ability to perform formal Japanese [...] Read more.
Background/Objectives: The preliminary experience with new dual-mobility system for small Japanese patients was introduced in this paper. Methods: Twenty-nine hips which underwent primary THA were retrospectively reviewed. All cups were inserted via Hardinge lateral approach. The ability to perform formal Japanese sitting in a kneeling position (Seiza in Japanese) and bowing while sitting (Zarei in Japanese) was evaluated. The mean follow-up was 6 months. Results: The mean age at surgery was 70 years, mean height was 156 cm, mean weight was 58 kg, and mean body mass index was 23.6. The acetabular cups utilized were a hemispherical hydroxy-apatite coated cup (25 hips) and a hemispherical trabecular titanium cup (4 hips), with diameters of 46 mm in 5, 48 mm in 15, 50 mm in 3, 52 mm in 1, 54 mm in 3, 56 mm in 1, and 62 mm in 1; mean diameter was 49.4 mm. No postoperative dislocations including intraprosthetic dislocation or metal allergy were observed. The mean Harris hip score improved significantly from 39 points preoperatively to 89 points postoperatively (p < 0.05). Radiographic evaluation demonstrated bone ingrowth stability in all cases according to Engh’s criteria and no aseptic loosening of the implants. Mean hip flexion increased from 75° preoperatively to 90° postoperatively (p < 0.05). The ability to perform Seiza increased from 8 patients preoperatively to 23 patients postoperatively (p < 0.05). The ability to perform Zarei (deep bowing) increased from 7 patients preoperatively to 20 patients postoperatively (p < 0.05). Conclusions: This novel dual-mobility system designed for smaller Japanese patients offers three distinct advantages: (1) availability of 42, 44, 46 and 48–66 mm outer diameter cups, (2) 1 mm deeper center of rotation, providing increased jumping distance compared to other designs, and (3) improved assembly instrumentation (cement-gun-type bearing press). Early clinical results suggest that this newly developed dual-mobility THA system is well-suited to the lifestyle and anatomical characteristics of Japanese patients. Full article
(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
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