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The Role of Inflammation in Gastroenterological Malignancies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 1629

Special Issue Editors


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Guest Editor
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: neuroimmune mechanisms of liver disease to novel diagnostic techniques in gastroenterology

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Guest Editor
Department of Internal Medicine-Pneumology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: ultrasound; pulmonary tuberculosis; chronic obstructive airway diseases; interstitial lung disease; lung cancer; pulmonary rehabilitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Digestive cancers are a group of diseases that affect millions, annually causing numerous deaths. Studies published in recent years identified the important role of inflammation in the pathogenesis of all types of cancer, including those of the digestive tract.

In this Special Issue “The Role of Inflammation in Gastroenterological Malignancies”, we invite you to publish your original research articles, clinical studies, literature reviews, meta-analyses, and clinical cases dealing with the role of inflammation in tumor pathogenesis and disease spread in digestive cancers. Papers can discuss esophageal, stomach, small intestine, colon, and rectal cancers, including research on inflammatory markers and other useful biomarkers in the diagnosis and prognosis of digestive cancers, the development of new therapeutic targets and new molecules in oncological treatment, and alternatives to standard treatment.

This Special Issue aims to help with the development of new pathogenic mechanisms in digestive cancers, further studying the well-known pathogenic mechanisms, while also helping with the development of new diagnosis methods and new biomarkers for early diagnosis, to establish the most accurate prognosis and, finally, to achieve more effective therapeutic methods.

Prof. Dr. Cristin Constantin Vere
Prof. Dr. Costin Teodor Streba
Guest Editors

Manuscript Submission Information

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Keywords

  • digestive cancers
  • inflammation
  • biomarkers
  • gastric cancer
  • liver cancer
  • colon and rectal cancer

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Published Papers (1 paper)

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Research

17 pages, 1938 KiB  
Article
Comparison between Substance P and Calcitonin Gene-Related Peptide and Their Receptors in Colorectal Adenocarcinoma
by Robert-Emmanuel Șerban, Mihail Virgil Boldeanu, Dan Nicolae Florescu, Mihaela Ionescu, Mircea-Sebastian Șerbănescu, Lidia Boldeanu, Mirela-Marinela Florescu, Mioara-Desdemona Stepan, Vasile-Cosmin Obleagă, Cristian Constantin, Dragoş-Marian Popescu, Costin Teodor Streba and Cristin Constantin Vere
J. Clin. Med. 2024, 13(18), 5616; https://doi.org/10.3390/jcm13185616 - 22 Sep 2024
Cited by 1 | Viewed by 1256
Abstract
Background: Colorectal cancer is a major health problem that still causes many deaths worldwide. Neuropeptides, such as substance P and calcitonin gene-related peptide, play the neurotransmitter and neurohormone roles that increase tumor invasiveness and metastasis potential. This study aimed to see whether these [...] Read more.
Background: Colorectal cancer is a major health problem that still causes many deaths worldwide. Neuropeptides, such as substance P and calcitonin gene-related peptide, play the neurotransmitter and neurohormone roles that increase tumor invasiveness and metastasis potential. This study aimed to see whether these neuropeptides and their receptors—neurokinin 1 receptor and calcitonin receptor-like receptor—correlate with the diagnosis stage, tumor differentiation grade, and different patient characteristics in colorectal cancer and also to compare them. Methods: We performed serum analyses of substance P and CGRP levels in patients with colorectal cancer and also the immunohistochemical analysis of their receptors in colorectal tumors and then correlated them with the disease stage and with different tumor characteristics. Results: We demonstrated that both substance P and calcitonin gene-related peptide had increased levels in colorectal cancer and that their levels correlated with the stage of the disease and with the tumor differentiation grade. We also demonstrated the correlation of NK-1R and CRLR higher immunohistochemical scores with advanced and poorly differentiated tumors. Conclusions: This study demonstrates that the neuropeptides SP and CGRP and their receptors NK-1R and CRLR could play a role in the pathogenesis of colorectal cancer, and they could be used as diagnostic and prognostic markers and could represent potential therapeutic targets. Full article
(This article belongs to the Special Issue The Role of Inflammation in Gastroenterological Malignancies)
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