Submit to JCM Review for JCM Propose a Special Issue

Journal Menu

Journal Browser

Advances in Coronary Artery Disease

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Published Papers

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (28 April 2025) | Viewed by 7561

Share This Special Issue

Special Issue Editors

Dr. Filippo Zilio

E-Mail Website
Guest Editor

Department of Cardiology, Santa Chiara Hospital, APSS, Trento, Italy
Interests: acute coronary syndromes; spontaneous coronary artery dissection; MINOCA

Dr. Jose M Montero-Cabezas

E-Mail Website
Guest Editor

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Interests: complex coronary interventions; chronic total occlusions; mechanical circulatory support

Special Issue Information

Dear Colleagues,

Despite continuous improvements in the diagnostic and therapeutic options, coronary artery disease (CAD) remains one of the most important causes of mortality and morbidity worldwide, with different manifestations, like acute coronary syndromes (ACSs), chronic coronary syndromes (CCSs), and myocardial infarction with non-obstructive coronary artery disease (MINOCA). Information about physiology, diagnosis, and treatment strategies is required to pursue precision medicine in the field and improve the prognosis of these patients. This Special Issue welcomes submissions about the topic of CAD, from basic science to clinical data, including case reports, original research, and state-of-the-art reviews.

We look forward to your submissions!

Dr. Filippo Zilio
Dr. Jose M Montero-Cabezas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

coronary artery disease
acute coronary syndromes
chronic coronary syndromes
myocardial infarction with non-obstructive coronary artery disease
spontaneous coronary artery dissection
myocardial infarction
coronary physiology
multimodality imaging

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (6 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review, Other

11 pages, 408 KiB

Open AccessArticle

Results from Cardiovascular Examination Do Not Predict Cerebrovascular Macroangiopathy: Data from a Prospective, Bicentric Cohort Study

by Johanna Lepek, Michael Linnebank, Lars Bansemir and Axel Kloppe

J. Clin. Med. 2025, 14(7), 2366; https://doi.org/10.3390/jcm14072366 - 29 Mar 2025

Viewed by 331

Abstract

Background: There is a large overlap in the risk profiles and pathophysiologies of coronary artery disease (CAD) and cerebrovascular macroangiopathy. Therefore, this study aimed to analyse whether findings in CAD examination by coronary angiography or cardio-computer tomography (cardio-CT) are predictive of cerebrovascular macroangiopathy. Methods: Our study was a prospective, bicentric, cross-sectional cohort study. A total of 191 patients without earlier CAD diagnosis who underwent a cardio-CT scan or coronary angiography for the screening of CAD during clinical routine were serially included. Two groups were formed based on the criterion of CAD (yes/no), and both were subsequently examined using sonography of the carotids. The CAD scores Syntax score I, Agatston equivalent score, and CAD-RADS score as well as AHA classification were determined. In cerebrovascular examinations, plaques and stenoses of the internal carotid artery (ICA) and the intima-media thickness (IMT) of the common carotid artery were analysed. Demographic and medical data such as the presence of arterial hypertension, diabetes mellitus, obesity, nicotine abuse, and dyslipidaemia were documented. The primary endpoint was the nominal association between CAD and ICA stenosis controlled for age and gender; secondary endpoints were correlations between ICA stenoses and CAD scores. Results: Of the 191 serially recruited patients (58% male, 65 ± 11 yrs.), 101 fulfilled CAD criteria; 90 did not. Of all patients, 137 had ICA plaques, and 11 thereof had an ICA stenosis ≥ 50%. No association was found between CAD and ICA stenosis (Wald = 0.24; p = 0.624). Accordingly, there was no association between IMT and Syntax score I (Wald = 0.38; p = 0.706), Agatston equivalent score (Wald = 0.89; p = 0.380), CAD-RADS score (Wald = 0.90; p = 0.377), or AHA classification (Wald = 0.21; p = 0.837). Common cardiovascular risk factors, i.e., arterial hypertension (Wald = 4.47; p = 0.034), diabetes mellitus (Wald = 7.61; p = 0.006), and nicotine abuse (Wald = 0.83; p = 0.028), were associated with newly diagnosed CAD but not with ICA plaques, stenosis, or increased IMT. Conclusions: In our cohort, newly diagnosed CAD was associated with typical risk factors. However, neither CAD nor these risk factors were associated with cerebrovascular disease. This suggests that in patients without prior CAD diagnosis, findings from CAD examinations might not be reliably predictive of cerebrovascular disease. Full article

(This article belongs to the Special Issue Advances in Coronary Artery Disease)

► Show Figures

Figure 1

12 pages, 1700 KiB

Open AccessArticle

Does the Coronary Artery Bypass Grafting Impact the Survival of Men and Women Equally Compared to General Population? Results from KROK Registry and Polish Central Statistical Office

by Grzegorz Hirnle, Adrian Stankiewicz, Maciej Mitrosz, Sleiman Sebastian Aboul-Hassan, Szymon Kocańda, Marek Deja, Jan Rogowski, Romuald Cichoń, Wojciech Pawliszak, Paweł Bugajski, Zdzisław Tobota, Bohdan Maruszewski, Piotr Knapik, Michał Krejca, Marek Cisowski and Tomasz Hrapkowicz

J. Clin. Med. 2024, 13(23), 7440; https://doi.org/10.3390/jcm13237440 - 6 Dec 2024

Viewed by 921

Abstract

Objective: The aim of this study was to evaluate the impact of coronary bypass surgery (CABG) on long-term mortality, comparing survival rates to those of the general population in Poland. Methods: The study was based on the Polish National Register of Cardiothoracic Surgical Procedures (KROK). Between January 2009 and December 2019, 133,973 patients underwent CABG. The study included all patients who underwent primary CABG. After excluding reoperations and patients with missing key data, there were 132,760 remaining patients who participated in the study. In order to compare patients who underwent CABG with the general population, data from Polish life expectancy tables from the Central Statistical Office (CSO) were used. Results: In the general population (GP), there is a consistent decrease in survival for both women and men throughout the entire observation period. The decline in survivability is more pronounced in the male group. Unlike the CABG group, which is at risk of perioperative mortality, there is no initial drop in survivability in the GP. The early mortality rate in CABG group within 30 days was significantly higher in the group of women than in men (3.51% compared to 2.19%, p < 0.001). The annual mortality rate was higher in the group of women (6.7% vs. 5.14%), and survival time was shorter (345.5 ± 0.4 vs. 351.2 ± 0.2 days, p < 0.001). However, the total mortality over a 13-year period of observation did not differ significantly between the groups (30.17% for women vs. 29.6% for men, p = 0.996) with survival time 10.08 ± 0.02 years in men vs. 10.06 ± 0.03 in women, p = 0.996. Conclusions: CABG surgery equalizes the probability of survival between genders. In long-term observation men have a greater survival benefit than women if compared to the predicted survival of the general population. These observations may provide a new perspective on the choice of revascularization strategy in relation to gender. Full article

(This article belongs to the Special Issue Advances in Coronary Artery Disease)

► Show Figures

Figure 1

9 pages, 627 KiB

Open AccessArticle

Association of RDW–Albumin Ratio, TG-Glucose Index, and PIV with Coronary Artery Disease

by Emre Akkaya

J. Clin. Med. 2024, 13(23), 7003; https://doi.org/10.3390/jcm13237003 - 21 Nov 2024

Cited by 1 | Viewed by 861

Abstract

Objectives: This study aimed to investigate the impact of the RDW–albumin ratio (RAR), Triglyceride–glucose index (TGI), and pan-immune-inflammation value (PIV) on predicting prognosis in patients with coronary artery disease (CAD) and to assess the potential use of these biomarkers in clinical decision-making. Materials and Methods: This retrospective study involved patients diagnosed and treated from 2020 to 2024. The study population included individuals diagnosed with CAD (n = 450) as well as a control group without CAD (n = 150). Results: The RAR, TGI, and PIV were significantly higher in the CAD group (p < 0.01 for all). Furthermore, a high RAR was found to be a risk factor for CAD (OR = 1.4, 95% CI: 1.2–1.7, p < 0.01), while elevated TGI was also linked to an increased risk of CAD (OR = 1.5, 95% CI: 1.3–1.8, p < 0.01). Similarly, a high PIV was strongly associated with CAD risk (OR = 2.0, 95% CI: 1.7–2.4, p < 0.01). The combined analysis of RAR, TGI, and PIV yielded an AUC value of 0.78 (0.75–0.81), indicating that these biomarkers collectively provide high diagnostic accuracy for CAD, with a sensitivity of 74% and specificity of 77% (p < 0.01). Conclusions: In conclusion, our study not only emphasizes the significance of traditional risk factors in CAD, but also highlights new biomarkers that could improve predictive accuracy. The combined use of biomarkers such as the RAR, TGI, and PIV offers greater accuracy in diagnosing CAD. Thus, our research presents an innovative approach with the potential to enhance the prediction and management of CAD risk. Full article

(This article belongs to the Special Issue Advances in Coronary Artery Disease)

► Show Figures

Figure 1

11 pages, 2076 KiB

Open AccessArticle

Drug-Eluting Balloons in Calcified Coronary Lesions: A Meta-Analysis of Clinical and Angiographic Outcomes

by Borja Rivero-Santana, Alfonso Jurado-Roman, Guillermo Galeote, Santiago Jimenez-Valero, Ariana Gonzalvez, Daniel Tebar and Raul Moreno

J. Clin. Med. 2024, 13(10), 2779; https://doi.org/10.3390/jcm13102779 - 9 May 2024

Cited by 2 | Viewed by 1695

Abstract

Background: The usefulness of drug-eluting balloons (DEBs) has not been fully elucidated in calcified coronary lesions (CCLs). This meta-analysis aimed to evaluate the efficacy of DEBs compared to a drug-eluting stent (DES) in this setting. Methods: PubMed, EMBASE and Cochrane were searched through December 2023. The primary endpoint was 12 months major adverse cardiac events (MACE). Secondary endpoints included clinical outcomes and angiographic results after PCI and at a 12-month follow-up. Results: Five studies and a total of 1141 patients with 1176 coronary lesions were included. Overall, the DEB was comparable to DES in MACE (RR = 0.86, 95% CI: 0.62–1.19, p = 0.36), cardiac death (RR = 0.59, 95% CI: 0.23–1.53, p = 0.28), myocardial infarction (RR = 0.89, 95% CI: 0.25–3.24, p = 0.87) and target lesion revascularization (RR = 1.1, 95% CI: 0.68–1.77, p = 0.70). Although the DEB was associated with worse acute angiographic outcomes (acute gain; MD = −0.65, 95% CI: −0.73, −0.56 and minimal lumen diameter; MD = −0.75, 95% CI: −0.89, −0.61), it showed better results at 12 months follow-up (late lumen loss; MD = −0.34, 95% CI: −0.62, −0.07). Conclusions: This meta-analysis showed that the DEB strategy is comparable to DES in the treatment of CCLs in terms of clinical outcomes. Although the DEB strategy had inferior acute angiographic results, it may offer better angiographic results at follow-up. Full article

(This article belongs to the Special Issue Advances in Coronary Artery Disease)

► Show Figures

Figure 1

Review

Jump to: Research, Other

13 pages, 1995 KiB

Open AccessReview

Artificial Intelligence in Imaging for Personalized Management of Coronary Artery Disease

by Adrian Bednarek, Karolina Gumiężna, Piotr Baruś, Janusz Kochman and Mariusz Tomaniak

J. Clin. Med. 2025, 14(2), 462; https://doi.org/10.3390/jcm14020462 - 13 Jan 2025

Cited by 1 | Viewed by 1395

Abstract

The precision of imaging and the number of other risk-assessing and diagnostic methods are constantly growing, allowing for the uptake of additional strategies for individualized therapies. Personalized medicine has the potential to deliver more adequate treatment, resulting in better clinical outcomes, based on each patient’s vulnerability or genetic makeup. In addition to increased efficiency, costs related to this type of procedure can be significantly lower. Useful assistance in designing individual therapies may be assured by the adoption of artificial intelligence (AI). Recent years have brought essential developments in deep and machine learning techniques. Advances in technologies such as convolutional neural networks (CNNs) have enabled automatic analyses of images, numerical data, and video data, providing high efficiency in the creation of prediction models. The number of AI applications in medicine is constantly growing, and the effectiveness of these techniques has been demonstrated in coronary computed tomography angiography (CCTA), optical coherence tomography (OCT), and many others. Moreover, AI models may be useful in direct therapy optimization for patients with coronary artery disease (CAD), who are burdened with high risk. The combination of well-trained AI with the design of individual treatment pathways can lead to improvements in health care. However, existing limitations, such as non-adapted guidelines or the lack of randomized clinical trials to evaluate AI’s true accuracy, may contribute to delays in introducing automatic methods into practical use. This review critically appraises the developed tools that are potentially useful for clinicians in guiding personalized patient management, as well as current trials in this field. Full article

(This article belongs to the Special Issue Advances in Coronary Artery Disease)

► Show Figures

Figure 1

Other

Jump to: Research, Review

16 pages, 2996 KiB

Open AccessSystematic Review

Incidence and Predictors of Early and Late Radial Artery Occlusion after Percutaneous Coronary Intervention and Coronary Angiography: A Systematic Review and Meta-Analysis

by Aisha Khalid, Hans Mautong, Kayode Ahmed, Zaina Aloul, Jose Montero-Cabezas and Silvana Marasco

J. Clin. Med. 2024, 13(19), 5882; https://doi.org/10.3390/jcm13195882 - 2 Oct 2024

Cited by 2 | Viewed by 1490

Abstract

Introduction: Trans-radial access for coronary angiography and percutaneous coronary intervention (PCI) has gained popularity due to its advantages over the traditional transfemoral approach. However, radial artery occlusion (RAO) remains a common complication following trans-radial procedures. This study aimed to investigate the incidence of early and late RAO along with their risk factors. Methods: Six databases, Medline (Ovid), National Library of Medicine (MeSH), Cochrane Database of Systematic Reviews (Wiley), Embase, Scopus, and Global Index Medicus, were searched. The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were extracted and analyzed. Using a random-effect model, the primary endpoint was the overall incidence of RAO after invasive coronary procedures. Subgroup analysis and meta-regression were also performed to identify possible predictors of RAO. Results: A total of 41 studies with 30,020 patients were included. The overall incidence of RAO was 13% (95% CI = 0.09–0.16). The incidence of early RAO (within 24 h) was 14% (95% CI = 0.10–0.18) in 26 studies, while the incidence of late RAO (after 24 h) was 10% (95% CI = 0.04–0.16) in 22 studies. The average incidence rates of early RAO in studies with catheter sizes of <6 Fr, 6 Fr, and >6 Fr were 9.8%, 9.4%, and 8.8%. The overall effect size of female gender as a predictor was 0.22 with a 95% CI of 0.00–0.44. Age was a potential predictor of early RAO (B = 0.000357; 95% CI = −0.015–0.0027, p: 0.006). Conclusions: This meta-analysis provides essential information on the incidence of early (14%) and late (10%) RAO following angiographic procedures. Additionally, our findings suggest that female sex and age are possible predictors of RAO. A larger catheter, especially (6 Fr) and hemostatic compression time <90 min post-procedure, substantially reduced the incidence of RAO. The use of oral anticoagulation and the appropriate dosage of low-molecular-weight heparin (LMWH) does reduce RAO, but a comparison between them showed no statistical significance. Full article

(This article belongs to the Special Issue Advances in Coronary Artery Disease)

► Show Figures

Journal Menu

Journal Browser

Advances in Coronary Artery Disease

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Published Papers (6 papers)

Research

Review

Other

Further Information

Guidelines

MDPI Initiatives

Follow MDPI