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Head and Neck Cancer: Clinical Diagnosis and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: 15 May 2026 | Viewed by 623

Special Issue Editors


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Guest Editor
1. Medical Oncology Department, HM Sanchinarro Centro Oncologico Clara Campa, Madrid, Spain
2. Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
Interests: head and neck cancer; ctDNA; precision medicine; plasma biomarkers

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Guest Editor
Department of Medical Oncology, BC Cancer, Vancouver, BC, Canada
Interests: head and neck cancer; thyroid cancer; salivary gland cancer; biomarkers; precision medicine

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Guest Editor
Medical Oncology Department, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain
Interests: head and neck cancer; thyroid cancer; early drug development; precision medicine; immunotherapy; chemoradiotherapy; targeted therapies and clinical trials

Special Issue Information

Dear Colleagues,

The landscape of head and neck cancer diagnosis and treatment has evolved significantly in recent years. Advances in imaging techniques, molecular diagnostics, and liquid biopsy have improved the early detection and characterization of these tumors, enabling more precise and personalized care. At the same time, surgical innovations, refined radiotherapy approaches, and the integration of immunotherapy have expanded therapeutic options and improved outcomes. Multidisciplinary care has become a cornerstone in managing these complex diseases, ensuring that patients benefit from coordinated expertise across specialties.

Despite this progress, challenges remain, particularly in detecting disease at earlier stages, tailoring therapy to individual tumor biology, and minimizing long-term functional and quality-of-life impairments. Continuous innovation and clinical research are therefore essential to advance standards of care and optimize patient outcomes.

In this Special Issue, we welcome submissions that highlight recent advances in the clinical diagnosis and treatment of head and neck cancers, including developments in imaging, biomarkers, surgical and non-surgical therapies, and multidisciplinary strategies.

Dr. Enrique Sanz-Garcia
Dr. Nicole Chau
Dr. Neus Baste
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck
  • multidisciplinary approaches
  • biomarkers
  • early detection
  • therapies

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Published Papers (1 paper)

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Research

11 pages, 679 KB  
Article
Topical Tranexamic Acid Application to Facilitate Biopsy Acquisition in Endoscopic Nasopharyngeal Biopsy: A Prospective Case Series Analysis
by Haldun Septar, Andra Iulia Suceveanu, Alina Doina Nicoara, Mihai Victor Lupascu, Alexandru Aristide Alexe, Iulia Cindea, Viorel Gherghina, Catalin Nicolae Grasa, Anca Pantea Stoian and Adrian Paul Suceveanu
J. Clin. Med. 2026, 15(6), 2275; https://doi.org/10.3390/jcm15062275 - 17 Mar 2026
Viewed by 346
Abstract
Background: Nasopharyngeal carcinoma diagnosis requires endoscopic biopsy, but intraoperative hemorrhage frequently impairs visualization and compromises tissue sampling quality. This prospective case series evaluated topical tranexamic acid (TXA) as a hemostatic adjunct to improve biopsy conditions in suspected nasopharyngeal malignancy. Methods: Adults (≥18 years) [...] Read more.
Background: Nasopharyngeal carcinoma diagnosis requires endoscopic biopsy, but intraoperative hemorrhage frequently impairs visualization and compromises tissue sampling quality. This prospective case series evaluated topical tranexamic acid (TXA) as a hemostatic adjunct to improve biopsy conditions in suspected nasopharyngeal malignancy. Methods: Adults (≥18 years) with clinically/radiologically suspected nasopharyngeal tumors underwent pre-biopsy laboratory screening and exclusion of thromboembolic risk factors. After topical lidocaine anesthesia, a TXA-soaked cotton pledget was applied to the lesion for 10 min prior to forceps biopsy using 0° 4 mm endoscopy. Bleeding severity was graded pragmatically (minimal: ≤3 gauze pledgets; moderate: >3 or cauterization). Comparative analyses excluded rare diagnoses (n = 1). Results: Of 40 enrolled patients, 34 underwent biopsy (mean age 58.4 ± 12.3 years). All 34 biopsies (100%) yielded conclusive histopathological diagnoses. Adequate hemostasis was achieved in 97.1% (33/34), with minimal bleeding in 76.5% and moderate/massive in 23.5%. Non-keratinizing squamous cell carcinoma (44.1%) showed higher moderate bleeding rates than other diagnoses (Fisher’s exact p = 0.00035). Mean hospitalization was 1.79 ± 1.92 days, uniform across categories. No TXA-related adverse events occurred. Conclusions: Topical TXA provided safe, effective hemostasis during nasopharyngeal biopsy across diverse pathologies, achieving 100% diagnostic adequacy and short hospital stays. Controlled trials comparing TXA versus standard hemostatic techniques are warranted. Full article
(This article belongs to the Special Issue Head and Neck Cancer: Clinical Diagnosis and Treatment)
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